A Comparison of Fentanyl and Flurbiprofen Axetil on Serum <scp>VEGF</scp>‐C, <scp>TNF</scp>‐α, and <scp>IL</scp>‐1ß Concentrations in Women Undergoing Surgery for Breast Cancer

Wen, Yiyun; Wang, Mingde; Yang, Jinfeng; Wang, Yichun; Sun, Hao; Zhao, Jianghong; Liu, Weizhen; Zhou, Zhengyu; Deng, Hongwu; Castillo-Pedraza, Catalina; Zhang, Yi; Candiotti, Keith A.

doi:10.1111/papr.12206

Cited by 29 publications

(28 citation statements)

References 34 publications

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“…In this study, satisfactory analgesia was achieved in both groups but the sufentanil consumption of PCA in the SF group was not reduced than that in the S group. It was reported that flurbiprofen axetil combined with smaller dosage of fentanyl significantly enhanced analgesia effect and reduced side effects of vomiting (Wen et al, ). However, in other studies, postoperative administration of flurbiprofen axetil, 100 mg/day, did not reduce the opioids consumption or improve analgesia effects (Liu, Chai, & Chen, ; Nonaka, Hara, Miyamoto, Sugita, & Yamamoto, ).…”

Section: Discussionmentioning

confidence: 99%

Effect of flurbiprofen axetil on postoperative delirium for elderly patients

Wang

et al. 2019

Brain and Behavior

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Objectives Proinflammatory cytokines triggered by surgery and postoperative pain are major causes of postoperative delirium (POD). This study investigated the effects of flurbiprofen axetil on POD when used for postoperative analgesia after major noncardiac surgery in elderly patients. Methods Patients over 65 years old were randomly divided into two groups: the sufentanil group (S group), in which 150 μg of sufentanil was used in the patient‐controlled analgesia (PCA) pump for 3 days; the sufentanil combined with flurbiprofen axetil group (SF group), in which 150 μg of sufentanil was combined with 300 mg of flurbiprofen axetil in the PCA pump for 3 days. The Confusion Assessment Method scale was used for POD evaluation. The pain intensity, side effects, and risk factors (age, gender, surgical position, and category of surgery) for POD were evaluated. Results Ultimately, 140 patients were included. The overall incidence of POD was not significantly different between the S and SF groups. The incidence of POD was significantly lower in the SF group than in the S group among patients over 70 years (5.1% vs. 20.7%, p = 0.045, odds ratio = 0.146, 95% confidence interval = 0.020–1.041). The incidence of POD was no difference in patients classified by the category of surgery, surgical position, or gender between groups. Sufentanil and flurbiprofen axetil in the PCA pump was completely used within 72 hr. The pain intensity, consumed sufentanil dosage of the PCA, and the side effects was not different between groups. Conclusions Flurbiprofen axetil might reduce POD in patients over 70 years undergoing major noncardiac surgery.

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Section: Discussionmentioning

confidence: 99%

Effect of flurbiprofen axetil on postoperative delirium for elderly patients

Wang

et al. 2019

Brain and Behavior

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“…11 Wen et al showed that flurbiprofen decreased VEGF-C, TNF-α, and IL-1β serum levels compared to fentanyl in patients undergoing mastectomy. 28 Narahara et al showed better cytotoxic immune function in patients receiving flurbiprofen compared to fentanyl. 29 In the present study, the slight immune suppression observed at the end of surgery in all three groups was not affected by flurbiprofen preemptive analgesia.…”

Section: Discussionmentioning

confidence: 99%

“…Shen et al showed that flurbiprofen combined with morphine could improve immune suppression in T and NK cells in cancer patients . Wen et al showed that flurbiprofen decreased VEGF‐C, TNF‐α, and IL‐1β serum levels compared to fentanyl in patients undergoing mastectomy . Narahara et al showed better cytotoxic immune function in patients receiving flurbiprofen compared to fentanyl .…”

Section: Discussionmentioning

confidence: 99%

Effects of preemptive analgesia with flurbiprofen ester on lymphocytes and natural killer cells in patients undergoing esophagectomy: A randomized controlled pilot study

et al. 2017

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Background: Tumors may induce systemic immune dysfunction, which can be aggravated by surgery and anesthesia/analgesia. Data on the effect of flurbiprofen preemptive analgesia on immune dysfunction is limited. The aim of this study was to investigate the effect of flurbiprofen preemptive analgesia on lymphocytes and natural killer (NK) cells in patients undergoing thoracotomy and thoracoscopy radical esophagectomy, and to explore the analgesic methods suitable for tumor patients.Methods: This was a randomized controlled pilot study of 89 patients with esophageal cancer treated with surgery at the Henan Cancer Hospital between January 1, 2015 and December 31, 2016. The patients were divided into three groups: group 1, thoracotomy; group 2, thoracoscopy and laparoscopic surgery; and group 3, flurbiprofen, thoracoscopy, and laparoscopic surgery. CD3+, CD19 +, NK, CD4+, and CD8+ cells in whole blood were measured by flow cytometry 30 minutes before surgery (T0), at the end of the thoracic section of the procedure (T1), and at the end of the operation (T2). Results: There were no significant differences in CD3+, CD19+, CD8+, NK, and CD4+ cells between the three groups or regarding the time points during the procedure (all P > 0.05). Thoracotomy and thoracoscopy surgery resulted in similar immunological outcomes. Conclusion: Flurbiprofen ester preemptive analgesia did not suppress the immune function in patients and could be a safe analgesic method for patients with esophageal cancer undergoing surgery.

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“…While the patients of breast cancer were waiting for surgery treatment, the states of circadian disruption [49], improved serum levels of oxidative damage [50], inflammatory biomarkers and angiogenic factors [51] would make the tumor progress. These researches focused either on oxidative stress or on inflammatory states.…”

Section: Discussionmentioning

confidence: 99%

“…It was found that elevated inflammatory mediators including vascular endothelial growth factor-C (VEGF-C), tumor necrosis factor-α (TNF-α), and interleukin-1ß (IL-1ß) are associated with increased rates of breast cancer recurrence and metastasis of following surgery [14][15][16].Inflammatory biomarkers and scores are potentially important prognostic factors in breast cancer during the perioperative period.…”

Section: Introductionmentioning

confidence: 99%

Reduction of Inflammatory Response by Way of Oxidative Stress with San Huang Decoction (SHD) In Perioperative Care: A Randomized Clinical Trial

Yu¹,

Weihe²,

Xu³

et al. 2017

IJCAM

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A Comparison of Fentanyl and Flurbiprofen Axetil on Serum VEGF‐C, TNF‐α, and IL‐1ß Concentrations in Women Undergoing Surgery for Breast Cancer

Abstract: In patients undergoing a mastectomy, postoperative analgesia with flurbiprofen axetil, combined with fentanyl, were associated with decreases in serum concentrations of VEGF-C, TNF-α, and IL-1ß compared with patients receiving doses of only fentanyl.

Cited by 29 publications

References 34 publications

Effect of flurbiprofen axetil on postoperative delirium for elderly patients

Effect of flurbiprofen axetil on postoperative delirium for elderly patients

Effects of preemptive analgesia with flurbiprofen ester on lymphocytes and natural killer cells in patients undergoing esophagectomy: A randomized controlled pilot study

Reduction of Inflammatory Response by Way of Oxidative Stress with San Huang Decoction (SHD) In Perioperative Care: A Randomized Clinical Trial

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