2004
DOI: 10.1176/jnp.16.1.57
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A Comparison of Family History of Psychiatric Disorders Among Patients With Early- and Late-Onset Alzheimer’s Disease

Abstract: The authors found preliminary evidence of a higher prevalence of a history of psychiatric symptoms among relatives of EOAD patients when compared to LOAD patients. This may be due to differential misclassification of AD, a syndromic disorder with both noncognitive psychiatric and cognitive deficits in relatives of EOAD patients. Alternatively, shared genetic or other familial etiologies may underlie subtypes of EOAD and some psychiatric disorders.

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Cited by 21 publications
(11 citation statements)
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“…Several studies have noted differences in clinical characteristics between EOAD and LOAD patients, particularly in symptoms and disease course. Devi et al (2004) found preliminary evidence of a higher prevalence of a history of psychiatric symptoms among relatives of EOAD patients when compared to LOAD patients. Some earlier studies (Martin et al, 1988;Lawlor et al, 1989;Li et al, 1992;van Ojen et al, 1995;Fahim et al, 1998) have shown increased occurrence of depression and other psychiatric disorders among the relatives of patients with AD.…”
Section: Introductionmentioning
confidence: 78%
See 1 more Smart Citation
“…Several studies have noted differences in clinical characteristics between EOAD and LOAD patients, particularly in symptoms and disease course. Devi et al (2004) found preliminary evidence of a higher prevalence of a history of psychiatric symptoms among relatives of EOAD patients when compared to LOAD patients. Some earlier studies (Martin et al, 1988;Lawlor et al, 1989;Li et al, 1992;van Ojen et al, 1995;Fahim et al, 1998) have shown increased occurrence of depression and other psychiatric disorders among the relatives of patients with AD.…”
Section: Introductionmentioning
confidence: 78%
“…As cognitive and psychiatric features are important components of AD, there is a definite need to explore the presence of psychiatric symptoms and disorders in families of patients with AD. Significant differences have been reported in the prevalence of psychiatric symptoms between EOAD and LOAD families which may imply differential misclassification of a primary dementing disorder as a primary non-dementing psychiatric disorder (Devi et al, 2004). Conversely, these differences may implicate shared genetic influences amongst subtypes of psychiatric symptoms and subtypes of AD.…”
Section: Introductionmentioning
confidence: 99%
“…Alzheimer's disease (AD) is a brain disorder that affects cognitive functions such as memory, intellect, and rationality (Devi et al, 2004;Kaiser & Panegyres, 2007) in about 6% of the population over 65 years of age (Ferri et al, 2006). Disinhibition and challenging social behaviors caused by AD influence both persons with AD and their family members (Chang et al, 2010).…”
Section: Introductionmentioning
confidence: 99%
“…Alzheimer's disease (AD) is a multispectral brain disorder that includes psychiatric, movement, and cognitive abnormalities [1]. The latest epidemiological studies have projected that the global prevalence of AD will increase from 27 million worldwide in 2006 to 135 million in 2050 [2].…”
Section: Introductionmentioning
confidence: 99%