Is there a familial overlap between dementia and other psychiatric disorders?

Narayanaswamy, Janardhanan C.; Varghese, Mathew; Jain, Sanjeev; Sivakumar, P. T.; Prakash, Om; Bharath, Srikala; Thennarasu, Kandavel

doi:10.1017/s1041610210001572

Cited by 7 publications

(6 citation statements)

References 28 publications

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“…To date, only a few studies have addressed the question of familial comorbidity in schizophrenia and dementia, and they have generated opposing findings. Our findings in this study were consistent with the prior findings of no coaggregation between schizophrenia and Alzheimer's dementia from the larger case-control studies [ 11 , 20 ], but they were in discrepancy with the finding of coaggregation between psychosis or mental disorders and Alzheimer's dementia in other case-control studies [ 21 , 23 ]. However, the latter studies were confined by very small sample sizes, making the associations found debatable.…”

Section: Discussionsupporting

confidence: 70%

“…To elucidate the relationship between schizophrenia and dementia, other studies have addressed the question of familial coaggregation between the two disorders. These studies have yielded incongruent results, with 2 case-control studies [ 11 , 20 ] finding no co-occurrence of schizophrenia and dementia (except frontotemporal dementia), and 3 case-control studies [ 21 , 22 , 23 ] finding increased incidence of mental disorders and psychoses in first-degree relatives of dementia probands. These studies are characterized by a limited number of cases, missing contemplation of dementia as a heterogeneous syndromic entity, and the use of a case-control design, which may have led to a considerable recall bias regarding psychiatric history, making it difficult to distill the findings and to draw any substantial conclusions.…”

Section: Introductionmentioning

confidence: 99%

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Does Schizophrenia in Offspring Increase the Risk of Developing Alzheimer's Dementia

Rohde

Agerbo

Nielsen

2016

Dement Geriatr Cogn Disord Extra

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Background/Aims: Prior studies have consistently found a higher risk of dementia in individuals with schizophrenia, but whether this is due to a common etiology between the disorders remains obscure. We wanted to elucidate this association by investigating whether schizophrenia in offspring increases the risk of Alzheimer's dementia. Methods: All individuals born between 1930 and 1953 were identified through national registers and followed from their 50th birthday until the date of Alzheimer's dementia, death or end of the study. Regressions were performed to evaluate the association between offspring with schizophrenia and Alzheimer's dementia. Results: Individuals with offspring with schizophrenia did not have an increased risk of Alzheimer's dementia [incidence rate ratio (IRR), 0.97; 95% CI, 0.88-1.07] compared to individuals with offspring without psychiatric contact. This finding remained stable when evaluating early-onset (IRR, 1.10; 95% CI, 0.91-1.31) and late-onset Alzheimer's dementia (IRR, 0.92; 95% CI, 0.88-1.07). Similar findings were made for vascular and unspecified dementia. Conclusion: The finding of no familial coaggregation between schizophrenia and Alzheimer's dementia may suggest that no common etiology between the disorders exists. This may indicate that the excess risk of dementia in individuals with schizophrenia is a by-product of the higher rates of somatic comorbidity and adverse health risk factors among these individuals.

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Section: Discussionsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Does Schizophrenia in Offspring Increase the Risk of Developing Alzheimer's Dementia

Rohde

Agerbo

Nielsen

2016

Dement Geriatr Cogn Disord Extra

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Section: Discussionmentioning

confidence: 75%

“…In continuation with the prior study conducted at our institute where the significantly higher morbid risk for psychosis in EOAD proband families was reported using survival analysis, 16 we proposed to study the familial loading of dementia in families of patients with schizophrenia to establish the familial coaggregation.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have addressed the familial coaggregation of the two disorders and have yielded incongruent results. [11][12][13][14][15] Narayanaswamy et al 16 reported significantly higher morbid risk for psychosis in early-onset dementia (EOAD) proband families and proposed a possibility of genetic overlap between dementia and psychosis. Thereby, in continuation of the proposal, there is a definite need to study the familial loading of dementia in families of patients with schizophrenia, to establish familial coaggregation.…”

Section: Original Articlementioning

confidence: 99%

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Familial Co-Aggregation of Dementia with Schizophrenia: A Cross Sectional Pedigree Analysis

Chawan¹,

Jain

Garg³

2021

Indian Journal of Psychological Medicine

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Background: Cognitive impairment is the core outcome defining feature in schizophrenia. Schizophrenia, in the context of a broader neurodegenerative conceptualization, may have shared etiology with major neurocognitive disorders (MNCD). To elucidate this association there is definite need to explore the familial loading of dementia, in families of patients with schizophrenia. Methods: The authors compared relatives including parental generation and siblings of 100 cases (schizophrenia probands) and 100 controls (anxiety disorder) in order to assess the familial co-aggregation of MNCD. All cases and control were screened with Mini International Neuropsychiatric Interview screen for psychiatric morbidity. The pedigree analysis was conducted by family history method and Family Interview for Genetic Studies. Cognitive impairment in pedigree was screened by community screening instrument for dementia. Results: There was nonreporting of MNCD in the total 2538 relatives (proband siblings +parental generation) of both cases and controls. Diabetes mellitus was the most common somatic morbidity, found significantly more among the parental generation of cases than healthy controls ( χ2 (1, 1713) = 6.452, P < 0.05). The odds of having various psychiatric and medical morbidities in the schizophrenia families compared to control are less than 1. Conclusion: There is no familial co-aggregation of MNCD in schizophrenia probands and common etiology between the two is less likely. Either schizophrenia could be counter-intuitively protective for MNCD or a reversible risk factor that can be prevented by effective treatments

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Mutation burden profile in familial Alzheimer's disease cases from India

Adhikarla

Sen

Kota

et al. 2018

Neurobiology of Aging

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Is there a familial overlap between dementia and other psychiatric disorders?

Abstract: There is a possible genetic overlap between dementia and psychosis. This appears to be more pronounced with early onset dementia than with late onset dementia.

Cited by 7 publications

References 28 publications

Does Schizophrenia in Offspring Increase the Risk of Developing Alzheimer's Dementia

Does Schizophrenia in Offspring Increase the Risk of Developing Alzheimer's Dementia

Familial Co-Aggregation of Dementia with Schizophrenia: A Cross Sectional Pedigree Analysis

Mutation burden profile in familial Alzheimer's disease cases from India

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