A Comparison of Duloxetine Plasma Levels in Postbariatric Surgery Patients Versus Matched Nonsurgical Control Subjects

Abstract

To our knowledge, this is the first reported study exploring duloxetine pharmacokinetics PBS. This trial found that the bariatric surgery group was exposed to only 57.7% of duloxetine as compared to the nonsurgery group. This finding suggests that clinicians need to monitor patients closely after bariatric surgery and that further exploration of the effects of bariatric surgery on antidepressant pharmacokinetic parameters is warranted.

Comparison of Bioavailability of Single‐Dose Extended‐Release Venlafaxine Capsules in Obese Patients Before and After Gastric Bypass Surgery

“…These results were consistent with the results for sertraline in other studies . The same research group performed a similarly designed matched nonsurgical control study with duloxetine . Post–bariatric surgery patients had significantly lower AUC and T max of duloxetine.…”

Psychiatric Disorders and weight Change in a Prospective Study of Bariatric Surgery Patients: A 3-Year Follow-Up

“…Interestingly, rates of any psychiatric medication usage, as well as any antidepressant medication or any antianxiety medication, remained relatively stable during the period of investigation, despite the reduced number of individuals meeting diagnostic criteria for any psychiatric disorder. Relatively little is known about clinical pharmacology after bariatric surgery, but two studies show evidence of reduced bioavailability of antidepressants after RYGB (33,34). Developing a better understanding of pharmacokinetics of psychotropic medications after surgery will inform clinical management of this patient population.…”

Physiologically‐Based Pharmacokinetic Modeling for the Prediction of CYP2D6‐Mediated Gene–Drug–Drug Interactions

“…The x‐axis represents time after drug intake (hour), and the y‐axis represents plasma concentration (ng/mL). Observed data were taken from published trials: ( a–d ) ( e, f ) ( g, h ) ( i ) and ( j )…”