A Comparison of Cinnarizine and Transdermal Scopolamine for the Prevention of Seasickness in Naval Crew

Gil, Amnon; Nachum, Zohar; Tal, Dror; Shupak, Avi

doi:10.1097/wnf.0b013e31823dc125

Cited by 27 publications

(9 citation statements)

References 6 publications

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“…Researchers found that meclizine had a slower start point with a longer duration of action (12 to 24 h), but it was associated with a wider range of side effects [ 190 ]. It has been indicated that scopolamine is more effective for MS treatment in comparison to cinnarizine [ 91 , 108 ]. Scopolamine prevents vestibular signals to the vestibular nuclei and possibly has a direct effect on the vomiting center in the brain [ 190 ].…”

Section: Discussionmentioning

confidence: 99%

“…Cinnarizine was first generated as a medication that blocks the H 1 histamine receptor. However, various studies have shown that the calcium channel blocker activity of cinnarizine is also involved in treating MS and vertigo [ 89 , 90 , 91 , 92 ]. In other words, cinnarizine is a medication that works by blocking the movement of calcium ions across the sensory cells in the inner ear, which are responsible for detecting motion and maintaining balance [ 93 ].…”

Section: Interventions For Mitigating Motion Sicknessmentioning

confidence: 99%

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Nutritional and Behavioral Countermeasures as Medication Approaches to Relieve Motion Sickness: A Comprehensive Review

et al. 2023

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The mismatch in signals perceived by the vestibular and visual systems to the brain, also referred to as motion sickness syndrome, has been diagnosed as a challenging condition with no clear mechanism. Motion sickness causes undesirable symptoms during travel and in virtual environments that affect people negatively. Treatments are directed toward reducing conflicting sensory inputs, accelerating the process of adaptation, and controlling nausea and vomiting. The long-term use of current medications is often hindered by their various side effects. Hence, this review aims to identify non-pharmacological strategies that can be employed to reduce or prevent motion sickness in both real and virtual environments. Research suggests that activation of the parasympathetic nervous system using pleasant music and diaphragmatic breathing can help alleviate symptoms of motion sickness. Certain micronutrients such as hesperidin, menthol, vitamin C, and gingerol were shown to have a positive impact on alleviating motion sickness. However, the effects of macronutrients are more complex and can be influenced by factors such as the food matrix and composition. Herbal dietary formulations such as Tianxian and Tamzin were shown to be as effective as medications. Therefore, nutritional interventions along with behavioral countermeasures could be considered as inexpensive and simple approaches to mitigate motion sickness. Finally, we discussed possible mechanisms underlying these interventions, the most significant limitations, research gaps, and future research directions for motion sickness.

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Section: Discussionmentioning

confidence: 99%

Section: Interventions For Mitigating Motion Sicknessmentioning

confidence: 99%

Nutritional and Behavioral Countermeasures as Medication Approaches to Relieve Motion Sickness: A Comprehensive Review

et al. 2023

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“…Çà ðóáåaeîì ïðîâåäåíû ðàáîòû ïî âíåäðåíèþ êîììåð÷åñêèõ îáðàçöîâ òðàíñäåðìàëüíûõ ôîðì â ñèñòåìó îêàçàíèÿ ïîìîùè ðàíåíûì è ïîðàaeåííûì. Ðåçóëüòàòû êëè-íè÷åñêèõ èññëåäîâàíèé ïëàñòûðåé ñî ñêîïîëàìèíîì äëÿ ïðåäóïðåaeäåíèÿ íàðóøåíèé îïåðàòîðñêîé ðàáîòîñïîñîáíîñòè ïðè ìîðñêîé è âîçäóøíîé áîëåçíè óêàçûâàþò íà âûñîêóþ ýôôåêòèâíîñòü òàêîãî ñïîñîáà äîñòàâêè è ñíèaeåíèå ïî-áî÷íûõ Ì-õîëèíåðãè÷åñêèõ ýôôåêòîâ [5].…”

Section: âîåííàß ôàðìàöèß è ìåäèöèíñêàß òåõíèêàunclassified

Factors of suicidal behavior in military personnel with borderline mental disorders

Иванов¹,

Чепур²,

Nikiforov³

et al. 2019

Bulletin of the Russian Military Medical Academy

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The article assesses the current level of technical devices and dosage forms intended for the use of medical protective equipment, discusses global trends and prospects for their short-term and medium-term development. Considered foreign samples autoinjectors, portable inhalers, patch pump, nasal, transdermal and buccal forms. Presents indicators of the effectiveness of various dosage forms, their advantages and disadvantages, discusses ways to overcome the latter in the provision of medical care in the prehospital stages and in transporting the wounded and affected. When assessing the possibility of using medical protection in various technical devices or dosage forms, it is necessary to consider the characteristics of their manufacturability and the readiness of the domestic production base for mass production and state registration as medicines or medical products. It was concluded that in the short term for the development of domestic medical remedies it is advisable to introduce inhaled and intranasal forms of drugs for use in the prehospital medical care.

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“…It has been shown to be more effective in preventing motion sickness than promethazine, meclizine, and lorazepam and has shown superiority over cinnarizine for sea sickness prevention in naval crew. 58,59 Caffeine may also be of benefit when combined with other anti-nauseants for motion sickness; caffeine plus promethazine was shown to be superior to scopolamine in preventing air sickness among helicopter passengers. 60 Importantly, scopolamine has not been shown to affect cognitive performance or manual dexterity in hyperbaric chamber dives.…”

Section: Sea Sicknessmentioning

confidence: 99%

Scuba diving and otology: a systematic review with recommendations on diagnosis, treatment and post operative care

2017

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Scuba diving is a popular recreational and professional activity with inherent risks. Complications related to barotrauma and decompression illness can pose significant morbidity to a diver's hearing and balance systems. The majority of dive-related injuries affect the head and neck, particularly the outer, middle and inner ear. Given the high incidence of otologic complications from diving, an evidence-based approach to the diagnosis and treatment of otic pathology is a necessity. We performed a systematic and comprehensive literature review including the pathophysiology, diagnosis, and treatment of otologic pathology related to diving. This included inner, middle, and outer ear anatomic subsites, as well as facial nerve complications, mal de debarquement syndrome, sea sickness and fitness to dive recommendations following otologic surgery. Sixty-two papers on diving and otologic pathology were included in the final analysis. We created a set of succinct evidence-based recommendations on each topic that should inform clinical decisions by otolaryngologists, dive medicine specialists and primary care providers when faced with diving-related patient pathology.

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A Comparison of Cinnarizine and Transdermal Scopolamine for the Prevention of Seasickness in Naval Crew

Cited by 27 publications

References 6 publications

Nutritional and Behavioral Countermeasures as Medication Approaches to Relieve Motion Sickness: A Comprehensive Review

Nutritional and Behavioral Countermeasures as Medication Approaches to Relieve Motion Sickness: A Comprehensive Review

Factors of suicidal behavior in military personnel with borderline mental disorders

Scuba diving and otology: a systematic review with recommendations on diagnosis, treatment and post operative care

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