A Comparison of Chlorhexidine, Cetylpyridinium Chloride, Triclosan, and C31G Mouthrinse Products for Plaque Inhibition

Abstract

There are a large number of mouthrinse products available to the general public for use as adjuncts to oral hygiene. Many have not been evaluated and relatively few comparisons of products have been made. This study compared 4 mouthrinse products containing cetylpyridinium chloride (CPC), chlorhexidine, C31G, or triclosan with saline rinse included as a placebo control. Twenty dentate volunteers took part in this 4-day plaque regrowth study which had a single blind, randomized cross-over design balanced for residual effects. On day 1 of each study period, volunteers were rendered plaque free by a professional prophylaxis, suspended normal oral hygiene measures, and rinsed twice daily for 1 minute with 15 mL of the allocated rinse. On day 5, subjects were scored for disclosed plaque by plaque index and plaque area. By both measures the order of decreasing product efficacy was chlorhexidine, CPC and triclosan, C31G, and saline. All the differences in favor of the chlorhexidine product were highly significant as were those in favor of the other rinses compared to saline. It is concluded that the findings of this study reflect the actual chemical benefits of the products divorced from the indeterminate variable of toothbrushing.

Antimicrobial efficacy of Curcuma zedoaria extract as assessed by linear regression compared with commercial mouthrinses

“…For instance, Renton-Harper et al (23) observed that formulas containing chlorhexidine presented greater antimicrobial activity than cetylpyridinium chloride and triclosan, as well as Monfrin and Ribeiro (14), whose experiments indicated that products containing chlorhexidine were more effective in reducing microbial populations in the saliva of volunteers, whereas products containing triclosan led to small decreases, and those containing essential oils did not reduce microbial populations.…”

Cytotoxicity and Antimicrobial Activity of Oral Rinses In Vitro

“…Representative standard formulations of oral rinses are supplemented with chlorhexidine digluconate, ethanol, essential oils, and detergents [7, 8]. Oral rinses can contain anti-inflammatory glucocorticoids and aloe vera, anesthetics such as lidocaine and morphine, antifungal nystatin, antihistamine diphenhydramine, and antimicrobials [9–11].…”

The effect of adjunctive chlorhexidine mouthrinse on clinical parameters and gingival crevicular fluid cytokine levels in untreated plaque-associated gingivitis

“…Although there are many products used to control plaque and gingivitis, chlorhexidine digluconate (CHX) has received the greatest attention due to its superior clinical and microbiological effectiveness [5][6][7][8]. It is considered as the gold standard for oral antiseptics [9].…”