A Comparison of Brilliant Blue G, Trypan Blue, and Indocyanine Green Dyes to Assist Internal Limiting Membrane Peeling During Macular Hole Surgery

Shukla, Dhananjay; Kalliath, Jay; Neelakantan, Nithya; Naresh, Kannan B.; Ramasamy, Kim

doi:10.1097/iae.0b013e318213618c

Cited by 62 publications

(54 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Their results showed improved visual acuity in 56-85% of patients. 4,10,15 Ocublue Plus has only been recently used clinically as an adjuvant in macular hole surgery. Its complications are unknown as there have not been any documented preclinical and clinical studies using it.…”

Section: Discussionmentioning

confidence: 99%

“…4,12,13,14,15 Ocublue Plus has already been widely used clinically but its complications are unknown as there has not been any documented preclinical and clinical studies using it.…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies have reported that BBG is similar to ICG in the case of ILM peeling during macular hole surgery. 4 ICG is approved for intravenous use while its intravitreal application represents an off-label use. It can be found under different brands such as ICG-Pulsion (Pulsion Medical Systems, Feldkirchen, Germany; 25 and 50 mg vials); ICV Indocianina Verde (Ophthalmos, Sao Paulo, Brazil; 5, 25, and 50 mg vials); Diagnogreen (Daiichi Sankyo, Tokyo, Japan; 25 mg vial); IC-Green (Akorn Inc., Lake Forrest, IL, USA; 25 mg vial) and Aurogreen (Aurolab, Madurai, Tamil Nadu, India; 25 mg vials).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The structural effect of intravitreal Brilliant blue G and Indocyanine green in rats eyes

Ooi

Khang

Naidu

et al. 2012

Eye

View full text Add to dashboard Cite

Purpose To compare the potential retinal toxicity of two commercially Brilliant blue G dyes (Brilliant Peel and Ocublue Plus) and Indocyanine green (ICG) at usual clinical concentration. Methods Brilliant Peel 0.025% (n ¼ 9), Ocublue Plus 0.025% (n ¼ 9), and ICG 0.05% (n ¼ 9) were injected intravitreally into Sprague-Dawley rat left eyes with balanced salt solution injected in the contralateral eyes as control. Evaluation of the effect of the dyes on retinal architecture was done by histological analysis of neurosensory retinal thickness and retinal ganglion cell (RGC) counts 7 days after intravitreal injection. Paired t-test was done to detect the presence of biologically significant thinning in neurosensory retina and five retinal layers for each dye (paired t-tests). One-way ANOVA and Tukey's Honestly Significant Difference test were used to assess whether different dyes caused significant thinning in mean neurosensory retinal thickness and reduction of mean RGC density. Results Eyes treated with ICG had significantly thinner mean total neurosensory retinal thickness compared with the control eyes (P-value ¼ 0.01), followed by those treated with Ocublue Plus (P-value ¼ 0.03). Brilliant Peel did not cause significant thinning in any of the five retinal layers (all P-values40.05). No significant difference in mean thinning of the total retinal thickness was detected between dyes (P-value ¼ 0.11). The mean thickness of the photoreceptor outer segment and outer plexiform layers were significantly reduced in ICG-injected eyes when compared with the control eyes (P-value ¼ 0.02). No significant difference in mean thinning between the three dyes was detected at all five retinal layers using one-way ANOVA (all P-values40.35). RGC density was significantly reduced for ICG (P-value ¼ 0.01) but only marginally for Ocublue Plus (P-value ¼ 0.05). No significant reduction in RGC density was observed for Brilliant Peel (P-value ¼ 0.2). Conclusion Intravitreal Brilliant Peel is safe to rats retina. The retinal thinning and reduction in RGC density induced by Ocublue Plus requires further studies to determine the safety profile of this product. Potential retinal toxicity is seen with ICG 0.05%.

show abstract

Section: Discussionmentioning

confidence: 99%

“…4,12,13,14,15 Ocublue Plus has already been widely used clinically but its complications are unknown as there has not been any documented preclinical and clinical studies using it.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The structural effect of intravitreal Brilliant blue G and Indocyanine green in rats eyes

Ooi

Khang

Naidu

et al. 2012

Eye

View full text Add to dashboard Cite

show abstract

“…8,24 Possible explanations for poor visual outcomes suggested ICG might alter the cleavage plane to involve the innermost retinal layer, and it might also have phototoxicity or direct toxic effects on the exposed retinal pigment epithelium (RPE) at the base of the macular hole. 6,7 It has been reported that ICG can remain in the eye for several months, and infrared hyperfluorescence from ICG may persist for up to 36 months after ICG-assisted ILM peeling.…”

Section: Discussionmentioning

confidence: 99%

“…12 Since ICG toxicity on RPE may occur right after exposure to the dye, protection of the exposed RPE at the base of the macular hole may be an important issue, and other dyes with greater safety, such as brilliant blue G, may be a better choice. 24 In conclusion, ICG-assisted ILM peeling has anatomical and functional benefits for idiopathic full-thickness macular holes. Autologous serum did not further increase the hole closure rate.…”

Section: Kung and Wumentioning

confidence: 99%

The Effect of Autologous Serum on Vitrectomy with Internal Limiting Membrane Peeling for Idiopathic Macular Hole

Kung

2013

Journal of Ocular Pharmacology and Therapeutics

View full text Add to dashboard Cite

Purpose: We sought to evaluate the effects of intraoperative adjunctive autologous serum in idiopathic fullthickness macular hole surgeries, and to compare the surgical outcomes with a no-serum control group. Methods: In this retrospective, case-control study, 38 consecutive eyes received vitrectomy with internal limiting membrane removal for idiopathic full-thickness macular holes. Two groups were created according to the use of autologous serum. Outcome measures were visual acuity (VA), closure of the macular hole confirmed by optical coherence tomography, and surgical complications. Results: Anatomical closure of the macular hole was achieved in 18 of 19 eyes (94.7%) in the vitrectomy with the autologous serum group, and in 18 of 19 eyes (94.7%) in the control group. The closure rates did not differ significantly between 2 groups (P = 1.000; the Fisher's exact test). At the final follow-up, the mean logMAR VA improved significantly in both groups (SD, standard deviation) [from 1.08 (0.21) to 0.47 (0.21) in vitrectomy with the serum group and from 1.01 (0.32) to 0.44 (0.30) in the control group (both P < 0.001; 2 tailed, paired t test)]. There was no significant difference between these 2 groups in terms of visual outcomes (P = 0.738; 2-tailed t test). There were no surgical complications, such as retinal detachment and endophthalmitis. Conclusions: The outcome of macular hole surgery did not differ both anatomically and functionally regardless of the use of adjuvant autologous serum. There seemed to be no additive effect with autologous serum.

show abstract

Role of ganglion cell complex in visual recovery following surgical internal limiting membrane peeling

Pierro

Iuliano

Gagliardi

et al. 2014

Graefes Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

show abstract

A Comparison of Brilliant Blue G, Trypan Blue, and Indocyanine Green Dyes to Assist Internal Limiting Membrane Peeling During Macular Hole Surgery

Abstract: Brilliant blue G was comparable with TB in optimizing visual and functional outcomes, while it was similar to ICG in ease of internal limiting membrane peeling.

Cited by 62 publications

References 23 publications

The structural effect of intravitreal Brilliant blue G and Indocyanine green in rats eyes

The structural effect of intravitreal Brilliant blue G and Indocyanine green in rats eyes

The Effect of Autologous Serum on Vitrectomy with Internal Limiting Membrane Peeling for Idiopathic Macular Hole

Role of ganglion cell complex in visual recovery following surgical internal limiting membrane peeling

Contact Info

Product

Resources

About