A comparison of acute lung inflammation in Klebsiella pneumoniae B5055-induced pneumonia and sepsis in BALB/c mice

Kumar, Vijay; Chibber, Sanjay

doi:10.1186/cc8058

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2021

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“…Pneumonia refers to lung inflammation, which is a frequently occurring and common disease of the respiratory system [ 1 , 2 ]. Pneumonia can occur in people of any age, but the young, the aged and the people with immune deficiency or poor immune system are high-risk patients [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Active disease-related compound identification based on capsule network

Yang

Bao

Wang

2021

Briefings in Bioinformatics

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Pneumonia, especially corona virus disease 2019 (COVID-19), can lead to serious acute lung injury, acute respiratory distress syndrome, multiple organ failure and even death. Thus it is an urgent task for developing high-efficiency, low-toxicity and targeted drugs according to pathogenesis of coronavirus. In this paper, a novel disease-related compound identification model–based capsule network (CapsNet) is proposed. According to pneumonia-related keywords, the prescriptions and active components related to the pharmacological mechanism of disease are collected and extracted in order to construct training set. The features of each component are extracted as the input layer of capsule network. CapsNet is trained and utilized to identify the pneumonia-related compounds in Qingre Jiedu injection. The experiment results show that CapsNet can identify disease-related compounds more accurately than SVM, RF, gcForest and forgeNet.

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Section: Introductionmentioning

confidence: 99%