A Comparison of 3T and 7T in the Detection of Small Parenchymal Veins Within MS Lesions

Tallantyre, Emma; Morgan, Paul S.; Dixon, Jennifer; Al-Radaideh, Ali; Brookes, Matthew J.; Evangelou, Nikos; Morris, Peter G.

doi:10.1097/rli.0b013e3181b4c144

Cited by 139 publications

(143 citation statements)

References 11 publications

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“…Our study is one of only several that have demonstrated the feasibility of detection of CVS on 3T MRI in MS,19, 20, 30, 31 and only a few studies have investigated whether the CVS distinguishes MS from other populations at 3T 16, 18. Lummel et al 16.…”

Section: Discussionmentioning

confidence: 89%

“Central vessel sign” on 3T FLAIR* MRI for the differentiation of multiple sclerosis from migraine

Solomon

Schindler

Howard³

et al. 2015

Ann Clin Transl Neurol

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ObjectiveThe diagnosis of multiple sclerosis (MS) presently relies on radiographic assessments of imperfect specificity. Recent data using T2* methodology for the detection of the “central vessel sign” (CVS) in MS lesions suggests this novel MRI technique may distinguish MS from other disorders. Our aim was to determine if evaluation for CVS on 3T FLAIR* MRI differentiates MS from migraine.MethodsPatients with MS or migraine and a prior brain MRI demonstrating at least two hyperintense lesions ≥3 mm were recruited. Exclusion criteria included any additional comorbidity known to cause brain MRI abnormalities. 3T MRI was performed in each participant with administration of gadopentetate dimeglumine, and FLAIR* images were generated in postprocessing. The total number of discrete ovoid lesions ≥3 mm were counted on FLAIR, per participant, and subsequently evaluated for presence of CVS on FLAIR*. An exploratory method evaluating for CVS in a maximum of 12 lesions per subject was also completed.ResultsTen participants with MS and 10 with migraine completed the study. The median percentage (quartiles) of lesions in MS participants with CVS was 84 (79, 94) compared to 22 (15, 54) in migraine (P = 0.008). In a subanalysis by brain region, in the subcortical and deep white matter, the median percentage (quartiles) of lesions in MS participants with CVS was 88 (81, 100) compared to 19 (11, 54) in migraine (P = 0.004). This difference was not identified in juxtacortical, periventricular, or infratentorial regions.InterpretationIdentification of CVS using FLAIR* on 3T MRI helps differentiate MS from migraine, particularly in the subcortical and deep white matter.

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Section: Discussionmentioning

confidence: 89%

“Central vessel sign” on 3T FLAIR* MRI for the differentiation of multiple sclerosis from migraine

Solomon

Schindler

Howard³

et al. 2015

Ann Clin Transl Neurol

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“…These signs are particularly visible with MRI systems that operate at high magnetic field strengths (≥3.0 T). [42][43][44][45][46][47][48][49] Susceptibilityweighted imaging (SWI), a sequence first described in 2004, 50 has also shown high sensitivity for detecting ironcontaining tissue and small veins because of their paramagnetic properties. This capability has conferred added value to MRI for diagnostic purposes, particularly when SWI is co-registered and mixed with standard pulse sequences such as T2 fluid-attenuated inversion recovery (FLAIR), which is termed FLAIR*.…”

Section: Differential Diagnosis Via Detection Of Iron and Veinsmentioning

confidence: 99%

MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis—clinical implementation in the diagnostic process

et al. 2015

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| The clinical use of MRI in patients with multiple sclerosis (MS) has advanced markedly over the past few years. Technical improvements and continuously emerging data from clinical trials and observational studies have contributed to the enhanced performance of this tool for achieving a prompt diagnosis in patients with MS. The aim of this article is to provide guidelines for the implementation of MRI of the brain and spinal cord in the diagnosis of patients who are suspected of having MS. These guidelines are based on an extensive review of the recent literature, as well as on the personal experience of the members of the MAGNIMS (Magnetic Resonance Imaging in MS) network. We address the indications, timing, coverage, reporting and interpretation of MRI studies in patients with suspected MS. Our recommendations are intended to help radiologists and neurologists standardize and optimize the use of MRI in clinical practice for the diagnosis of MS.

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“…Die genauen pathophysiologischen Zusammenhänge in der Entstehung der MS sind bisher unzureichend verstanden [21,58] Gegenüberstellung zwischen 3-T-und 7-T-MRT ist eine Überlegenheit der 7-T-MRT hinsichtlich quantitativer Parameter nicht zwangsläufig gegeben [20,75,106] Auf weitere Studien mit differentialdiagnostischer Bedeutung wird in den Abschnitten "Susac-Syndrom" und "Neuromyelitis-optica-Erkrankungsspektrum" näher eingegangen. Neben dieser quantitativ verbesserten Detektionsrate ermöglicht die UHF-MRT darüber hinaus eine exaktere in-vivo-Einteilung der KL [70] in ihre vier pathologischen Klassifikationsformen [11], welche in Abbildung 4 dargestellt sind.…”

Section: Multiple Skleroseunclassified

Ultrahochfeld-MRT im Kontext neurologischer Erkrankungen

et al. 2014

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A Comparison of 3T and 7T in the Detection of Small Parenchymal Veins Within MS Lesions

Cited by 139 publications

References 11 publications

“Central vessel sign” on 3T FLAIR* MRI for the differentiation of multiple sclerosis from migraine

“Central vessel sign” on 3T FLAIR* MRI for the differentiation of multiple sclerosis from migraine

MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis—clinical implementation in the diagnostic process

Ultrahochfeld-MRT im Kontext neurologischer Erkrankungen

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