Ultrahochfeld-MRT im Kontext neurologischer Erkrankungen

Kuchling, Joseph; Sinnecker, Tim; Bozin, Ivan; Dörr, Jan; Madai, Vince I.; Sobesky, Jan; Niendorf, Thoralf; Paul, Friedemann; Wuerfel, Jens

doi:10.1007/s00115-013-3967-5

Cited by 7 publications

(6 citation statements)

References 123 publications

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“…Furthermore, a hypointense rim surrounding WM lesions, hypothesized to represent iron-loaded macrophages and activated microglia, was a common finding in patients with MS, but it was not detectable in patients with NMO spectrum disorder (Figure 4). 47 The majority of lesions (>85%) in patients with NMO spectrum disorder were subcortical, 46 and no periventricular lesions or “Dawson’s fingers,” a characteristic feature of MS, 51 were observed. 52 Interestingly, none of these studies described the macroscopic cortical pathology of NMO spectrum disorders, 53 despite the description of microscopic meningeal inflammation, cortical demyelination, and neuronal loss in histological analyses.…”

Section: Ultrahigh-field and High-field Mrimentioning

confidence: 99%

Use of Advanced Magnetic Resonance Imaging Techniques in Neuromyelitis Optica Spectrum Disorder

et al. 2015

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Brain parenchymal lesions are frequently observed on conventional magnetic resonance imaging (MRI) scans of patients with neuromyelitis optica (NMO) spectrum disorder, but the specific morphological and temporal patterns distinguishing them unequivocally from lesions caused by other disorders have not been identified. This literature review summarizes the literature on advanced quantitative imaging measures reported for patients with NMO spectrum disorder, including proton MR spectroscopy, diffusion tensor imaging, magnetization transfer imaging, quantitative MR volumetry, and ultrahigh-field strength MRI. It was undertaken to consider the advanced MRI techniques used for patients with NMO by different specialists in the field.Although quantitative measures such as proton MR spectroscopy or magnetization transfer imaging have not reproducibly revealed diffuse brain injury, preliminary data from diffusionweighted imaging and brain tissue volumetry indicate greater white matter than gray matter degradation. These findings could be confirmed by ultrahigh-field MRI. The use of nonconventional MRI techniques may further our understanding of the pathogenic processes in NMO spectrum disorders and may help us identify the distinct radiographic features corresponding to specific phenotypic manifestations of this disease.

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Section: Ultrahigh-field and High-field Mrimentioning

confidence: 99%

Use of Advanced Magnetic Resonance Imaging Techniques in Neuromyelitis Optica Spectrum Disorder

et al. 2015

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“…Zudem zeigen Patienten ohne vorherige Optikusneuritis, je doch mit Läsionen in der Sehstrahlung deutliche VEP-Latenzverlän gerungen [32]. Entzündliche Läsionen in der mithilfe der Trakto grafie oder mittels Ultrahochfeld-MRT rekonstruierten Sehstrah lung führen darüber hinaus zu RNFL-und RNFL-Verlust in den betroffenen Arealen der Retina [125][126][127][128][129].…”

Section: Multiple Skleroseunclassified

Untersuchungen des visuellen Systems in der Neurologie: aktuelle Forschung und klinische Relevanz

et al. 2017

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Zusammenfassung Die orientierende Darstellung des afferenten visuellen Systems ist integraler Bestandteil der neurologischen Anamnese und der klinisch neurologischen Untersuchung. Durch die anatomische Zugeh?rigkeit zum zentralen Nervensystem, das Auftreten von Sehverlust bei vielen neurologischen Erkrankungen, und durch die erhebliche Bedeutung eines Sehverlustes f?r die Lebensqualit?t von Betroffenen erf?hrt die Untersuchung des afferenten visuellen Systems durch moderne diagnostische Verfahren zunehmende Bedeutung. Niedrigkontrast-Sehen oder Farbsehtests k?nnen klassische Visustests erg?nzen. Mithilfe von multifokal visuell evozierten Potenzialen k?nnen einzelne Str?nge der Sehbahn untersucht werden. Optische Koh?renztomografie erlaubt die hochaufgel?ste Darstellung der Netzhaut mit ihren einzelnen Schichten. Diffusionsbildgebung und funktionelle Magnetresonanztomografie erlauben in der Forschung die mikrostrukturelle und funktionelle Untersuchung des visuellen Systems. Strukturierte Frageb?gen k?nnen f?r das Screening auf Sehst?rungen genutzt werden. Eine detaillierte Untersuchung des afferenten visuellen Systems geh?rt zunehmend zur erweiterten neurologischen Untersuchung bei neuroimmunologischen Erkrankungen wie Multiple Sklerose, Neuromyelitis optica, MOG-IgG assoziierter Enzephalomyelitis oder Susac-Syndrom, aber auch beim Parkinson Syndrom oder anderen neurodegenerativen Erkrankungen. Dieser ?bersichtsartikel skizziert die Prinzipien der wichtigsten Methoden zur strukturellen und funktionellen Untersuchung des visuellen Systems und fasst exemplarisch die Ergebnisse der Anwendung dieser Methoden bei relevanten neurologischen Erkrankungen zusammen.

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“…Ultrahigh field (UHF) MRI at 7 T benefits from increased signal-to-noise ratio (SNR) and enhanced spatial resolution as good as 100 μm [ 3 ]. Future studies will show whether these 7 T MRI advantages indeed improve diagnosis and our understanding of the underlying pathophysiology in inflammatory CNS diseases.…”

Section: Reviewmentioning

confidence: 99%

Ultrahigh field MRI in clinical neuroimmunology: a potential contribution to improved diagnostics and personalised disease management

et al. 2015

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Conventional magnetic resonance imaging (MRI) at 1.5 Tesla (T) is limited by modest spatial resolution and signal-to-noise ratio (SNR), impeding the identification and classification of inflammatory central nervous system changes in current clinical practice. Gaining from enhanced susceptibility effects and improved SNR, ultrahigh field MRI at 7 T depicts inflammatory brain lesions in great detail. This review summarises recent reports on 7 T MRI in neuroinflammatory diseases and addresses the question as to whether ultrahigh field MRI may eventually improve clinical decision-making and personalised disease management.

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Ultrahochfeld-MRT im Kontext neurologischer Erkrankungen

Cited by 7 publications

References 123 publications

Use of Advanced Magnetic Resonance Imaging Techniques in Neuromyelitis Optica Spectrum Disorder

Use of Advanced Magnetic Resonance Imaging Techniques in Neuromyelitis Optica Spectrum Disorder

Untersuchungen des visuellen Systems in der Neurologie: aktuelle Forschung und klinische Relevanz

Ultrahigh field MRI in clinical neuroimmunology: a potential contribution to improved diagnostics and personalised disease management

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