A comparison between single-dose fosfomycin trometamol (Monuril®) and a 5-day course of trimethoprim in the treatment of uncomplicated lower urinary tract infection in women

Clinical significance of the pharmacokinetic and pharmacodynamic characteristics of fosfomycin for the treatment of patients with systemic infections

“…Fosfomycin therapy has not been found to be inferior in terms of clinical or microbiological effectiveness to 7-day pipemidic acid [45,46], 5-day amoxicillin/clavulanic acid [47]. 5-day trimethoprim/sulfamethoxazole [48], 7-day norfloxacin [49,50], 5-day cefalexin [51] or 7-day nitrofurantoin therapy [52].…”

Comparison of Fosfomysin Trometamol and Ciprofloxacin in Uncomplicated Urinary Tract Infections

“…Bu çalışmada her ne kadar klinik kür oranları her iki ajan için benzer ise de (%93 ve %94) nitrofurantoin yüksek erken mikrobiyolojik kür oranı (%86 nitrofurantoin, %78 FT) ile daha etkili bulunmuştur. Minassian ve arkadaşları [9] yine tek doz FT ile beş gün TMP/SMZ tedavisini karşılaştırmıştır. Bu çalışmada sadece mikrobiyolojik sonuçlar karşılaştırılmış ve her iki ajanın benzer etkinliğe sahip olduğu rapor edilmiştir.…”

Fosfomycin and Its Application in the Treatment of Multidrug-Resistant Enterobacteriaceae Infections

“…30,31 In spite of its wide spectrum of antibacterial activity, pharmaceutical development of the molecule has been limited as a consequence of difficulties in determining its in vitro activity 15 and its clinical efficacy. 18,32 These issues have led to restricted therapeutic use of fosfomycin as a single agent. However, at the present time, when there is a shortage of antibiotic research and a dramatic development of antimicrobial resistance, [33][34][35][36][37][38][39][40][41][42] previous prescribing habits must be reconsidered and better use made of the old antimicrobial agents, like fosfomycin.…”

“…55,186,187 The studies were nonblinded, single-blinded, or doubleblinded comparisons. A single 3 g dose of fosfomycin was compared with single doses of amoxicillin 3 g, 188,189 ofloxacin 200 mg, 190 norfloxacin 800 mg, 191 pefloxacin 800 mg, 192 trimethoprim 200 mg, 193 and cotrimoxazole 1920 mg. 190 A single dose of fosfomycin was also compared with amoxicillin + clavulanic acid 375 mg four times daily for five days, 194 cefalexin 500 mg four times daily for five days, 195 ciprofloxacin 500 mg twice daily for five days, 196 pipemidic acid 400 mg twice daily for 5-7 days, [197][198][199] norfloxacin 400 mg bid for 5-7 days, 197,[200][201][202][203] cotrimoxazole 480 mg twice daily for three days, 204 trimethoprim 200 mg twice daily for five days, 18 and nitrofurantoin 50 mg four times daily for seven days. 205 In these studies, the microbiological and clinical efficacies were similar, and 70%-95% microbial eradication rates were observed 5-11 days after treatment.…”

“…This underutilization was probably due to early problems in determining its true in vitro activity, 15 demonstrating its efficacy as a single agent, 15,18 and the resulting lack of inclination of pharmaceutical companies to perform clinical studies of fosfomycin in combination regimens. As a consequence of its spectrum of activity, low percentage of resistance, bactericidal effect, and pharmacokinetic properties, a single 3 g dose taken orally has been shown to be generally safe and effective in the treatment of lower urinary tract infections.…”