A comparison between Japanese-Americans living in Hawaii and Los Angeles and native Japanese: the impact of lifestyle westernization on diabetes mellitus

Nakanishi, Shuhei; Okubo, Masamichi; Yoneda, Masayasu; Jitsuiki, Kuniaki; Yamane, Kiminori; Kohno, Nobuoki

doi:10.1016/j.biopha.2004.10.001

Cited by 75 publications

(68 citation statements)

References 17 publications

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“…1). Previous epidemiological studies have reported that being underweight is likely to be associated with the risk of type 2 diabetes in the Japanese population [44,45] and that Japanese people have low insulin secretory capacity and a high risk of type 2 diabetes at BMIs lower than the existing WHO cut-off point for being overweight, 25 kg/m 2 [46,47]. Thus, together with other, unidentified confounding factors, the extent of obesity (>2/3 of the Japanese participants were underweight or normal weight) may account for cross-and within-population differences in type 2 diabetes susceptibility at obesity loci such as FTO.…”

Section: Discussionmentioning

confidence: 98%

Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individuals

et al. 2011

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Aims/hypothesis In populations of East Asian descent, we performed a replication study of loci previously identified in populations of European descent as being associated with obesity measures such as BMI and type 2 diabetes.Methods We genotyped 14 single nucleotide polymorphisms (SNPs) from 13 candidate loci that had previously been identified by genome-wide association meta-analyses for obesity measures in Europeans. Genotyping was done in 18,264 participants from two general Japanese populations. For SNPs showing an obesity association in Japanese individuals, we further examined diabetes associations in up to 6,781 cases and 7,307 controls from a subset of the original, as well as from additional populations.Electronic supplementary material The online version of this article

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Section: Discussionmentioning

confidence: 98%

Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individuals

et al. 2011

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“…The present study is part of a long-term epidemiological survey (Hawaii-Los Angeles-Hiroshima study) initiated in 1970 that continues to investigate risk factors for diabetes and cardiovascular disease among subjects limited to a population genetically equivalenttothenativeJapanesepopulation.Theepidemiological survey has been previously described in detailelsewhere [17][18][19][20] .Thesubjectsofthepresentstudy were Japanese-Americans enrolled in the Los Angeles portionofthelong-termepidemiologicalstudycarried out in 2010.The study population consisted of 439 Japanese-Americans(186menand253women)who werenotdiagnosedwithDMandnotusingmedications for dyslipidemia. We also excluded individuals withafastingtriglyceride(TG)levelofmorethan400 mg/dl in consideration of the use of the Friedewald equation 21) .…”

Section: Study Subjectsmentioning

confidence: 99%

“…In contrast, the cally equivalent to Japanese residing in Japan, although they have experienced rapid and intense westernization of their lifestyle. We previously reported that the prevalence of diabetes, metabolic syndrome and atherosclerotic disease is significantly greaterinJapanese-AmericansthaninJapaneseliving in Japan [17][18][19] .The effects of glucose and lipid abnormalities on the serum cholesterol efflux capacity are thereforeexpectedtobemorereadilyapparentinthis populationthaninnativeJapanese.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Serum Cholesterol Efflux Capacity and Glucose Intolerance in Japanese-Americans

Kubota

Nakanishi

Hirano

et al. 2014

JAT

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Aim: Serum cholesterol efflux has been suggested to be a key anti-atherogenic function of reverse cholesterol transport. Meanwhile, the quantitative and qualitative alteration of the levels of lipoproteins in the serum has been reported in patients with diabetes, although it remains unclear whether the serum cholesterol efflux capacity is impaired in cases of newly diagnosed glucose intolerance. We thus assessed the relationship between the serum cholesterol efflux capacity and glucose intolerance as detected using oral glucose tolerance tests (OGTTs). Methods: We measured the capacity of whole serum to mediate cholesterol efflux from human THP-1 macrophages in a cohort of 439 Japanese-Americans who underwent 75-g OGTTs. A multiple regression analysis was performed to examine the relationship between the serum cholesterol efflux capacity and glucose intolerance. Results: The serum cholesterol efflux capacity was found to be negatively correlated with the area under the curve for the serum glucose concentration during the 75-g OGTTs in all subjects. In addition, the serum cholesterol efflux capacity was found to be modestly but significantly lower in the glucose intolerance group (31.4±6.2%) than in the normal glucose tolerance group (33.2±6.1%). There was also a negative association between the serum cholesterol efflux capacity and glucose intolerance after adjusting for age and sex. Moreover, this association remained significant even after further adjustments for serum total cholesterol, high-density lipoprotein cholesterol, apolipoprotein AI and C-reactive protein. Conclusions:The serum cholesterol efflux capacity is impaired in Japanese-Americans newly diagnosed with glucose intolerance. This impairment may contribute in some manner to increasing the risk of atherosclerotic disease in subjects with glucose intolerance.

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“…Furthermore, recent studies have suggested that beta cell failure in T2DM is more apparent in Asians than in Caucasians [5,6]. This review summarizes the current understanding of beta cell failure in T2DM and discusses its clinical implications.…”

Section: Introductionmentioning

confidence: 97%

Obesity, Type 2 Diabetes and Beta Cell Failure: An Asian Perspective

Saisho¹

2014

J Mol Genet Med

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A comparison between Japanese-Americans living in Hawaii and Los Angeles and native Japanese: the impact of lifestyle westernization on diabetes mellitus

Cited by 75 publications

References 17 publications

Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individuals

Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individuals

Relationship between Serum Cholesterol Efflux Capacity and Glucose Intolerance in Japanese-Americans

Obesity, Type 2 Diabetes and Beta Cell Failure: An Asian Perspective

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