A comparative trial of intra‐nasal beclomethasone dipropionate and sodium cromoglycate in patients with chronic perennial rhinitis

Abstract

Summary A double‐blind crossover study has compared intra‐nasal sodium cromoglycate (SCG) with beclomethasone dipropionate (BDP), and both drugs with placebo, in fifty‐two chronic perennial rhinitis patients, BDP was significantly more effective in relieving symptoms than SCG (76.9% and 50% of the patients improved respectively, P<0.01). Both drugs were more active than placebos but while BDP was very clearly more effective (P<0.0005) SCG was only marginally better than its placebo (P<0.05, Fisher; P=0.068, χ2). BDP was selected by 56% of the patients as the best agent for continuing therapy at the end of the trial. By contrast SCG was preferred by the same number of patients as chose the two placebos (11.5%).

Drug treatment for nasal allergy

“…Flunisolide is as potent, but budesonide twice as potent, as BDP in tests of antiinflammatory activity, an effect mirrored in clinical studies [51]. Topical corticosteroids have been shown to be more efficacious than SCG in the control of nasal symptoms including obstruction in several double-blind trials [52,53]. In a double-blind, double-dummy comparative study of 61 adults with grass pollen-induced rhinitis, twice-daily treatment with budesonide (400 /ig) was superior to dexchlorpheniramine-sustained release tablets (6 mg b.d.)…”

Inferior turbinate reduction; coblation versus microdebrider - a prospective, randomised study

“…Medical management of these disorders include antihistamines, sympathomimetics, anti-cholinergics, immunotherapy, and corticosteroids either surface or intra-turbinal injection (7,8) . Unfortunately, long standing hypertrophy may become irreversible and does not respond to these medications anymore.…”

Intra turbinate diathermy cautery V/S high frequency in inferior turbinate hypertrophy

“…Nasal obstruction in chronic non allergic or hypertrophic rhinitis is usually caused by submucosal or mucosal hypertrophy and bogginess due to increased vascularity as anterior end of inferior turbinate is an erectile tissue. Various methods have been tried viz nasal decongestant or corticosteroid drops, oral antihistamines, sympathomimetics [1][2], [3], regular physical exercise (yoga), sutraneti, laser assisted turbinoplasty and argon plasma surgery (Jackson) [4], [5]. Epidemiological studies in European countries have shown incidence up to 20% of inferior turbinate hypertrophy [6].…”