Drug treatment for nasal allergy

Mast cells and allergic rhinitis

“…There is a greater density of metachrcinatically staining cells in the nasal epithelium of patients with allergic rhinitis ccmpared to non-rhinitics and the number of these cells Increases during natural allergen exposure. Whether these metachrcmatically staining cells are basophils or mast cells remains controversial as does the finding of an increasing number of mast cells in the lamina propria of allergic rhinitics over the course of the pollen season [3], The increase in the ntJiriber of metachrcmatically staining cells in both the nasal epithelium and lamina propria can be prevented by treatment both with topical corticosteroids and with nedocrorail sodixim 13]-I The majority of nasal mast cells like those in the mucosa of the lcwer respiratory tract differ frcxn mast cells in human skin or in the sub mucosa of the intestinal tract in that they do not stain with saffranin O indicating that they contain a proteoglycan other than heparin and do not degranulate on contact with the polyamine 48/80 indicating that they have some functional dissimilarities. In addition fixation with formol saline as opposed to Camoy's solution reduces the number of mast cells which can be detected follcwing staining with alcian blue or by the alpha-naphthol AST chloroacetate esterase reaction (CAER).…”

Symptomatische Therapie der allergischen Rhinitis

“…1, einen Durch die Enrwicklung moderner Antihistaminika mit ciner weitgehenden Spezifitat für Hi-Rezeptoren von Drüsen, Gefagen und sensorischen Nervenendigungen hat sich die Situation schiagartig geändert: Das Fehien der ohen genannten unerwdnschtenvar allem sedierenden -Nebenwirkungen beruht abet nicht nur auf ihrem potenteren Antagonismus für Hi-Rezeptoren, sondern auch auf ihrer verminderten Fähigkeit, die Blut-Gehirn-Schranke zu tiberwinden. Ganz ailgemein ist ihre Wirkung auf Hypersekretion, Juck-und Niesreiz besser als auf die nasale Obstruktion (17,23,40).…”