A comparative tissue distribution study of oxytetracycline in rainbow trout,<i>Oncorhynchus mykiss</i>(Walbaum), and chinook salmon,<i>Oncorhynchus tshawytscha</i>(Walbaum)

Namdari, Rostam; Abedini, Soheila; Law, F. C. P.

doi:10.1046/j.1365-2109.1999.00329.x

Cited by 18 publications

(6 citation statements)

References 23 publications

(35 reference statements)

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“…[39] However, uptake rates of pharmaceuticals can, for example, be affected by temperature, oxygen availability [36] and prey consumption, [6] whereas elimination patterns and half-lives of pharmaceuticals can be tissue-specific in fish. [40,41] In laboratory studies, fish are typically exposed to stable pharmaceutical concentrations under controlled and stable environmental conditions. However, individuals in natural systems move freely along different and temporally variable environmental gradients, such as gradients in temperature, oxygen and prey availability, as well as gradients of pharmaceutical contamination.…”

Section: Discussionmentioning

confidence: 99%

Tissue-specific uptake of the benzodiazepine oxazepam in adult Eurasian perch (Perca fluviatilis)

et al. 2016

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Environmental context. Although pharmaceuticals are found in wild fish, there is no consensus as to which fish tissue to use when measuring the pharmaceutical concentrations. Using the psychiatric pharmaceutical oxazepam in Eurasian perch as an example, we found that oxazepam was distributed in the perch tissues in the following order of concentration: muscle , liver ¼ brain , blood plasma. These results help to interpret and compare previous studies, and provide guidance for future studies.Abstract. Psychoactive substances are used worldwide and constitute one of the common groups of pharmaceutical contaminants in surface waters. Typically, in field surveys and laboratory studies, muscle or whole-body homogenates are used to quantify pharmaceutical concentrations in biota, although uptake of pharmaceuticals may be tissue-specific. Therefore, the aim of this study was to investigate the tissue-specific (muscle, liver, brain and blood plasma) uptake of the anxiolytic oxazepam in adult Eurasian perch (Perca fluviatilis). In laboratory experiments, perch were exposed to four different concentrations (2, 4, 12 and 20 mgL À1 ) of oxazepam for 6 days, and muscle, liver, brain tissue and blood plasma were sampled to determine tissue-specific bioconcentration. We found that the tissue-specific bioconcentration was independent of oxazepam concentration. However, among tissue types, bioconcentration was significantly different, with the concentration in muscle , liver ¼ brain , blood plasma. Hence, it is important to consider the type of tissue used to quantify pharmaceutical uptake in fish, for predictions of species-specific sensitivity and comparisons across studies. Furthermore, our results indicate a somewhat lower transportability (brain/plasma ratio 0.54) of oxazepam from blood to brain in fish compared with in mammals, which should be kept in mind when employing 'read-across' approaches.

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Section: Discussionmentioning

confidence: 99%

Tissue-specific uptake of the benzodiazepine oxazepam in adult Eurasian perch (Perca fluviatilis)

et al. 2016

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“…The elimination half‐life of OTC in E. sinensis was longer than that in fish (Xu & Rogers 1995; Namdari, Abedini & Law 1999; Zhang & Li 2007). Similarly, the elimination half‐lives of OTC in E. sinensis were longer than the corresponding values in M. rosenbergii and Penaeus chinensis (Wang, Lin, Xue & Khalid 2004a; Poapolathep et al.…”

Section: Discussionmentioning

confidence: 91%

Kinetic analysis of oxytetracycline residues in Chinese mitten crab, Eriocheir sinensis, muscle following intramuscular administration

Feng

Gao

et al. 2010

Journal of Fish Diseases

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Crab culture is a very important economic industry in China. An epidemic of tremor disease of Chinese mitten crabs, Eriocheir sinensis, has become a serious problem in recent years. A spiroplasm has been proved to be the causative agent of this disease. Oxytetracycline (OTC) is used widely in aquaculture and was confirmed to be very effective against this pathogen. In this study, the distribution and depletion patterns of OTC in crab muscle were evaluated following single intramuscular doses of 2, 8 and 40 mg kg(-1) body weight. OTC was detected with a validated HPLC method. Concentration-time profiles were well described by a three-compartment model with first-order absorption after a single dose of 8 and 40 mg kg(-1). For comparison, a non-compartment model was employed. A withdrawal time of 48.29 and 55.92 days was suggested prior to consumption after receiving 8 and 40 mg kg(-1). A recommended therapeutic dose of OTC in theory was calculated to be 36.37 mg kg(-1). OTC was distributed well throughout the body. The elimination of OTC in muscle was slower compared with fish and other crustaceans. A dose of 40 mg kg(-1) is suggested for practical use.

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“…In general, the T½ estimations for all trials were between 12 and 19.8 days post injection, except for T‐1 and T‐3 of Rainbow trout under controlled conditions. From a review of previous studies, a great variation in T½ estimations was observed, ranging from 2 to 15 days (Black, Ferguson, Byrne & Claxton, ; Meinertz et al., ; Namdari, Abedini & Law, , ). It is important to note that most of the studies reviewed showed T½ values around 5 days, and only one work showed a T½ of 15 days (Namdari et al., ), being the later carried out for rainbow trout and Chinook salmon after the administration of intravenous OTC at doses of 50 and 5 mg/kg, respectively.…”

Section: Resultsmentioning

confidence: 99%

Oxytetracycline depletion and withdrawal time estimation following intraperitoneal administration in three species from Chilean salmon farming

2017

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This study was conducted to evaluate the half-time (T½) and withdrawal time (WT) of oxytetracycline (OTC) following intraperitoneal (i.p.) administration of OTC (24.8-34.7 mg/kg) in three farmed salmonid species, Coho salmon (Oncorhynchus kisutch), Rainbow trout (Oncorhynchus mikiss) and Atlantic salmon (Salmo salar). A detection technique in fish skin muscle through a high-performance liquid chromatography (HPLC) with a diode array detector (DAD) was developed and validated. The depletion studies were carried out in controlled conditions (nine studies) and under field conditions (one study). The T½ and WT estimations from the skin muscle after the i.p. administration of OTC in salmonids appear to be longer than studies where the OTC was orally administrated. Furthermore, the OTC maximum concentration in muscle seems to be also higher in the i.p. treatment. Due to the prolonged WT following the i.p. OTC administration, cautions related to the salmon harvest time should be consider in order to prevent OTC traces in the final product. K E Y W O R D Sdepletion, high-performance liquid chromatography, intraperitoneal, oxytetracycline, salmonid

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A comparative tissue distribution study of oxytetracycline in rainbow trout,Oncorhynchus mykiss(Walbaum), and chinook salmon,Oncorhynchus tshawytscha(Walbaum)

Cited by 18 publications

References 23 publications

Tissue-specific uptake of the benzodiazepine oxazepam in adult Eurasian perch (Perca fluviatilis)

Tissue-specific uptake of the benzodiazepine oxazepam in adult Eurasian perch (Perca fluviatilis)

Kinetic analysis of oxytetracycline residues in Chinese mitten crab, Eriocheir sinensis, muscle following intramuscular administration

Oxytetracycline depletion and withdrawal time estimation following intraperitoneal administration in three species from Chilean salmon farming

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