A comparative study on the safety and immunogenicity of purified duck embryo cell vaccine (PDEV, Vaxirab) with purified chick embryo cell vaccine (PCEC, Rabipur) and purifed vero cell rabies vaccine (PVRV, Verorab)

Comparison of safety and immunogenicity of 2 WHO prequalified rabies vaccines administered by one week, 4 site intra dermal regimen (4-4-4-0-0) in animal bite cases

“…7,16,17,20 Similarly, the immune response in the present study on day 90 was comparable with Essen regimen. 20 All the study subjects in both the groups of vaccines on day 365 had adequate RVNA concentration of 0.5 IU/mL, whereas the previous study from India showed that the RVNA concentration was <0.5 IU/mL among 21.1% subjects in Rabipur group and 37.5% subjects in Verorab group. 7 The concomitant administration of ERIG in all category III exposures in the study did not suppress the immune response to rabies vaccines.…”

“…7,16,17,20 The immune response elicited in this study on day 14 was comparable with studies done using updated TRC regimen, Essen regimen and one week, 4 site intradermal regimen. 7,16,17,20 Similarly, the immune response in the present study on day 90 was comparable with Essen regimen.…”

“…7,16,17,20 The immune response elicited in this study on day 14 was comparable with studies done using updated TRC regimen, Essen regimen and one week, 4 site intradermal regimen. 7,16,17,20 Similarly, the immune response in the present study on day 90 was comparable with Essen regimen. 20 All the study subjects in both the groups of vaccines on day 365 had adequate RVNA concentration of 0.5 IU/mL, whereas the previous study from India showed that the RVNA concentration was <0.5 IU/mL among 21.1% subjects in Rabipur group and 37.5% subjects in Verorab group.…”

Evaluation of a one week intradermal regimen for rabies post-exposure prophylaxis: Results of a randomized, open label, active-controlled trial in healthy adult volunteers in India

“…The RVNA response of present ID regimen was comparable to RVNA response with updated TRC regimen, TRC regimen, 4 site intra dermal regimen and Essen IM regimens using PCECV and PVRV. [13][14][15][16][17] The only other study conducted on 4 site one week regimen is from Thailand by Shantavasinkul et al 3 When we compare our results with this study it is found that while 100% in Thailand about 5% patients do not come for the 4 th dose on day 28. 3 In two recent studies from India where updated TRC, IDRV is given in government hospitals, the completion/compliance rate to full course or taking 4 doses of vaccine including the one on day 28 was found to be 38.5% in a rural clinic and 75.5% in an urban clinic.…”

“…[13][14][15][16][17] However, all subjects in both the vaccine groups tolerated the vaccines and completed the full course of vaccination, thus indicating the acceptability of this new regimen. Indeed, a multiple site ID regimen consisting of 8 inoculations at different sites on day 0 was also well tolerated while it was practiced in the past.…”