A Comparative Study on the Effects of Excessive Consumption of Ginger, Clove, Red Pepper and Black Pepper on the Histology of the Kidney

Nwaopara, AO; Odike, M.A.C.; Inegbenebor, Ute; Nwaopara, S.O.; Ewere, G.I.

doi:10.3923/pjn.2008.287.291

Cited by 17 publications

(15 citation statements)

References 17 publications

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“…It has been proved that MSG induces oxidative stress in different organs, including the pancreas [26], liver [27], kidney [28], and thymus [29][30][31]. Previous studies has also suggested that glutamateinduced toxicity could be mediated via necrosis and apoptosis [32].…”

Section: Blood and Tissue Samplingmentioning

confidence: 99%

The Effects of Monosodium Glutamate on Thymic and Splenic Immune Functions and Role of Recovery (Biochemical and Histological study)

Hassan¹

2014

J Cytol Histol

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Citation: Hassan ZA, Arafa MH, Soliman WI, Atteia HH, Al-Saeed HF (2014) The Effects of Monosodium Glutamate on Thymic and Splenic Immune Functions and Role of Recovery (Biochemical and Histological study). AbstractMonosodium glutamate (MSG), a flavor enhancer, is used in modern nutrition to improve food palatability.The objectives of the current study were to investigate the effect of MSG on thymus as well as spleen structures and functions. Also, to evaluate the possibility of recovery after cessation of administration. Adult male rats were divided into three groups: control, MSG (3 g MSG/kg body weight daily for 8 weeks by oral gavages), and Recovery (MSG for same period and then left untreated for additional 4 weeks). The results showed that MSG treatments significantly increased serum interleukin (IL)-1β as well as thymic and splenic malondialdehyde and decreased serum levels of IL-10 and also reduced glutathione (GSH) levels and both catalase and superoxide dismutase activities in the thymus and spleen. Histological examination showed that MSG induced a remarkable disruption in the lobular architecture of the thymus with marked decrease of the T lymphocytes with darkly stained nuclei and dilated blood sinusoid in the cortical region. Medullary region were enlarged and repopulated with small lymphocytes and dilated blood sinusoids. The cortical-medullary differentiation was difficult to be determined. Small sized splenic lymphatic follicles with absence of germinal centers and large congested blood vessels were also noticed. The differentiation between the red and the white pulps was indistinct. Recovery groups showed preserved thymic lobular architecture with repopulation of the cortical thymocytes enclosing the paler staining medulla .Splenic lymphatic follicles of different sizes with absence of germinal centers were noticed. Marginal zone is differentiated from the red pulp. Immunohistochemical staining of MSG group demonstrated a marked decrease in CD3-positive T-lymphocytes in both thymus and spleen that significantly increased in recovery group. Taken together, the data showed that MSG consumption may have immunotoxic effects on the thymus and spleen of adult rats which is reversible but the normal structure of the spleen would need time to be regained. It is recommended that further studies aimed at corroborating these findings be carried out.

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Section: Blood and Tissue Samplingmentioning

confidence: 99%

The Effects of Monosodium Glutamate on Thymic and Splenic Immune Functions and Role of Recovery (Biochemical and Histological study)

Hassan¹

2014

J Cytol Histol

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“…Furthermore, Nwaopara et al . () reported that the excessive consumption of this spice is harmful to the liver and potentially harmful to kidney, although not harmful to the heart. However, this dish often also contain red meat and offals as constituents with a high dietary cholesterol content and which may be responsible for the high cholesterol content of this dish.…”

Section: Discussionmentioning

confidence: 99%

Lipid composition of some commonly consumed traditional Nigerian dishes

Onabanjo

Sanni

Afolabi

et al. 2013

J Human Nutrition Diet

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“…The available scientific data show that a disproportionately high consumption of yaji is capable of inducing kidney [32], pancreatic [33], liver [34], brain tissue [21,35], and heart [36] damage; therefore, it is necessary to investigate its effects on other vital organs, such as the testes, to clarify its role in male fertility. On this basis, the present study was designed to assess changes in the reproductive function and testicular OS status of albino Wistar rats following acute and subchronic oral ingestion of yaji.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the deleterious effects of yaji and cadmium chloride on testicular physiomorphological and oxidative stress status: The gonadoprotective effects of an omega-3 fatty acid

Ekhoye

Olerimi

Ehebha

2020

Clin Exp Reprod Med

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Objective: This study investigated testicular oxidative stress status and physiomorphological function in Wistar rats fed with yaji and cadmium chloride (CdCl2).Methods: Sixty male albino Wistar rats (12 per group) were randomly assigned to five groups: group I (control), group II (300 mg/kg.bw of yaji), group III (500 mg/kg.bw of yaji), group IV (2.5 mg/kg.bw of CdCl2), and group V (2.5 mg/kg.bw of yaji+4 mg/kg.bw omega-3). Each group was evenly subdivided into two subgroups and treatment was administered for 14 days and 42 days, respectively. Semen quality (sperm count, progressive motility, normal morphology, and gonadosomatic index), hormones (testosterone, follicle-stimulating hormone, and luteinizing hormone), testicular oxidative stress markers (superoxide dismutase, catalase, glutathione peroxidase, and malonaldehyde) and testicular histomorphological features were examined.Results: Yaji caused significant (p< 0.05) dose- and duration-dependent reductions in semen quality, the gonadosomatic index, testosterone, follicle-stimulating hormone, and luteinizing hormone. Yaji also caused significant (p< 0.05) dose- and duration-dependent decreases in superoxide dismutase, catalase, and glutathione peroxidase activity, as well as increased testicular malonaldehyde levels. Yaji induced distortions in the testicular histological architecture. CdCl2 damaged testicular function by significantly (p< 0.05) reducing semen quality, reproductive hormone levels, and oxidative stress markers in albino Wistar rats. CdCl2 also altered the histology of the testis.Conclusion: This study shows that yaji sauce has similar anti-fertility effects to those of CdCl2, as it adversely interferes with male reproduction by impairing oxidative stress markers and the function and morphological features of the testis.

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A Comparative Study on the Effects of Excessive Consumption of Ginger, Clove, Red Pepper and Black Pepper on the Histology of the Kidney

Cited by 17 publications

References 17 publications

The Effects of Monosodium Glutamate on Thymic and Splenic Immune Functions and Role of Recovery (Biochemical and Histological study)

The Effects of Monosodium Glutamate on Thymic and Splenic Immune Functions and Role of Recovery (Biochemical and Histological study)

Lipid composition of some commonly consumed traditional Nigerian dishes

Comparison of the deleterious effects of yaji and cadmium chloride on testicular physiomorphological and oxidative stress status: The gonadoprotective effects of an omega-3 fatty acid

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