A comparative study on the mutagenicity of ethylenethiourea in bacterial and mammalian test systems

Schüpbach, M.E.; Hummler, Hans

doi:10.1016/0027-5107(77)90199-3

Cited by 19 publications

(1 citation statement)

References 28 publications

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“…However Seiler (72) reported weak (dose unrelated) mutagenicity in S. typhimurium strain G46. ETU was also mutagenic in a host-mediated assay of S. typhimurium TA1530, when mice were dosed with 6000 mg ETU/kg body weight, but not at doses of 2000 mg/kg or less (73). Schupbach and Hummler (73,74) also reported that ETU appeared to induce base-pair mutations but not frameshift mutations in S. typhimurium TA98, TA 1537, and TA1538 exposed to ETU in the presence of dimethysulfoxide and/or liver microsomes (25).…”

Section: Methodsmentioning

confidence: 99%

Ethylenebisdithiocarbamates and ethylenethiourea: possible human health hazards.

Houeto

Bindoula

Hoffman

1995

Environ Health Perspect

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Humans are exposed to ethylenebisdithiocarbamates (EBDCs) from environmental sources. Exposure to EBDCs is chronic for workers in a variety of industries, where EBDCs are used for their properties as slimicides, vulcanization accelerators, antioxidants, and scavengers in waste-water treatment. EBDCs, and particularly the EBDC metabolite ethylenethiourea, have clearly defined, important toxic effects in various animal species, and there is reason to suspect they are carcinogenic in humans. In the absence of definitive information regarding human risk, further studies need to be done. In the interim, regular surveillance of workers with high levels of exposure to EBDCs, with specific attention to markers of thyroid and hepatic pathology, should be considered.Imagesp568-a

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Section: Methodsmentioning

confidence: 99%

Ethylenebisdithiocarbamates and ethylenethiourea: possible human health hazards.

Houeto

Bindoula

Hoffman

1995

Environ Health Perspect

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Ethylenthioharnstoff [MAK Value Documentation in German language, 1995]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 21. Lieferung, Ausgabe 1995 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Erfahrungen beim Menschen Einmalige Exposition Wiederholte Exposition Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Kanzerogenität Tierexperimentelle Befunde und in‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Bewertung

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Ethylene thiourea [MAK Value Documentation, 1998]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Occupational Toxicants , Vol. 11 (1998) The article contains sections titled: Toxic Effects and Modes of Action Mechanisms of Action Toxicokinetics and Metabolism Effects in Man Repeated exposure Allergenic effects Reproductive toxicity Carcinogenicity Animal Experiments and in vitro Studies Acute toxicity Subacute, subchronic and chronic toxicity Local effects on skin and mucous membranes Allergenic Effects Reproductive toxicity Genotoxicity Carcinogenicity Manifesto (MAK value, classification)

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A comparative study on the mutagenicity of ethylenethiourea in bacterial and mammalian test systems

Cited by 19 publications

References 28 publications

Ethylenebisdithiocarbamates and ethylenethiourea: possible human health hazards.

Ethylenebisdithiocarbamates and ethylenethiourea: possible human health hazards.

Ethylenthioharnstoff [MAK Value Documentation in German language, 1995]

Ethylene thiourea [MAK Value Documentation, 1998]

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