A comparative study on the antioxidant activities of an acidic polysaccharide and various solvent extracts derived from herbal Houttuynia cordata

Tian, Lingmin; Zhao, Yan; Guo, Chao; Yang, Xingbin

doi:10.1016/j.carbpol.2010.08.023

Cited by 140 publications

(90 citation statements)

References 28 publications

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“…As reported, the characteristic absorption peak at 1342.42 cm −1 was ascribed to the bending vibration of C-H Zheng et al, 2014). In addition, the stretching absorption peak at 1613.42 cm −1 along with the peak at 1419.59 cm −1 indicated the presence of COO − (Lee et al, 2013;Tian, Zhao, Guo, & Yang, 2011), Figura 4. Espectro FT-IR de APP en un rango de frecuencia de 4000-500 cm −1.…”

Section: Ft-ir Spectrum Of Appsupporting

confidence: 56%

“…It has been reported that the bioactivity of polysaccharides is highly related to the monosaccharide composition and contents . Besides, polysaccharides with more uronic acids have higher bioactivities due to the modified properties of polysaccharides, such as solubility (Tian, Zhao, Guo, & Yang, 2011). The total content of uronic acids (including both galacturonic acid and glucuronic acid) in APP was 14.4%, suggesting that APP may have a potential to be developed as one important plant extracts with biological responses.…”

Section: Monosaccharide Composition Of App By Gc-msmentioning

confidence: 99%

“…The balance of intracellular oxidative stress depends on both the cellular oxidant species and the antioxidant defence system in cells (Jia et al, 2011). Therefore, antioxidant supplementation to suppress the free radical-induced damage has become an alternative and promising therapeutic strategy for reducing the risk of liver diseases (Tian, Zhao, Guo, & Yang, 2011). In our study, APP was shown to have hepatoprotective effects against CCl 4 -induced liver damage, through significantly decreasing the level of MDA and elevating the enzymatic activities of GSH-Px and SOD in liver tissues, especially at the dosage of 450 mg/kg bw.…”

Section: Effects Of App On the Levels Of Mda Gsh-px And Sod In Hepatmentioning

confidence: 99%

“…Also, carbon tetrachloride (CCl 4 ), a widely applied hepatotoxin, has been used in establishing a liver-injured model to screen hepatoprotective medicines (Nada et al, 2010). However, there are limited numbers of hepatoprotective medicines in the commercial market, and some of them have been reported to have adverse effects, especially for chronic or subchronic administration (Tian, Zhao, Guo, & Yang, 2011). Therefore, natural antioxidant phytochemicals have recently been shown a substantial increase as alternative therapies of liver diseases because of better effectiveness and fewer side effects (Jiang et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Characterization, antioxidant activities and hepatoprotective effects of polysaccharides from pre-pressing separationFujiapple peel

Sun

Meng

Sun

et al. 2017

CyTA - Journal of Food

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Characterization, antioxidant activities and hepatoprotective effects of polysaccharides from prepressing separation apple (Fuji) peel pomace were investigated in this study. Gel permeation chromatography indicated that apple peel polysaccharides (APPs) were a kind of heteropolysaccharides composed of three fractions with homogenous polarity. Both GC-MS and HPLC analysis showed that arabinose, galactose and galacturonic acid were the main monosaccharides in APP. In vitro antioxidant activities of APP were characterized. Furthermore, administration of APP (450 mg/ kg bw) in mice significantly decreased the CCl 4 -induced elevations of serum alanine aminotransferase, asparate aminotransferase and lactic dehydrogenase activities, and hepatic malondialdehyde level and inhibited the decreases in superoxide dismutase and glutathione peroxidase activities caused by CCl 4 . Histopathological observation further confirmed that APP could protect the liver tissues from CCl 4 -induced histological alternation. These findings indicate that APP has the antioxidant and hepatoprotective potentials and provide a scientific basis for comprehensive utilization of pre-pressing separation apple peel pomace.Caracterización, actividad antioxidante y efectos hepatoprotectores de polisacáridos de la separación de la pela de manzana Fuji previamente prensada RESUMEN En este estudio se investigaron la caracterización, la actividad antioxidante y los efectos hepatoprotectores de los polisacáridos de la separación del orujo de pela de manzana (Fuji) previamente prensado. La cromatografía de permeación en gel indicó que los polisacáridos de la pela de manzana (APP) eran un tipo de heteropolisacáridos compuestos de tres fracciones con polaridad homogénea. Los dos análisis GC-MS y HPLC mostraron que la arabinosa, la galactosa y el ácido galacturónico fueron los principales monosacáridos en APP. Se caracterizó la actividad antioxidante in vitro de APP. Además, la administración de APP (450 mg/kg bw) en ratones disminuyó significativamente las elevaciones inducidas con CCl 4 de la alanina aminotransferasa sérica, el aspartato aminotransferasa, la actividad lactato deshidrogenasa y el nivel hepático de malondialdehído, además inhibió la disminución de la actividad de superóxido dismutasa y glutatión peroxidasa causada por CCl 4 . Posteriormente la observación histopatológica confirmó que APP podría proteger los tejidos del hígado de la alternación histológica inducida con Cl 4 . Estos hallazgos indican que APP tiene potencial antioxidante y hepatoprotector, además proporciona una base científica para una utilización integral de la separación de orujo de pela de manzana previamente prensado. ARTICLE HISTORY

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Section: Ft-ir Spectrum Of Appsupporting

confidence: 56%

Section: Monosaccharide Composition Of App By Gc-msmentioning

confidence: 99%

Section: Effects Of App On the Levels Of Mda Gsh-px And Sod In Hepatmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Characterization, antioxidant activities and hepatoprotective effects of polysaccharides from pre-pressing separationFujiapple peel

Sun

Meng

Sun

et al. 2017

CyTA - Journal of Food

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“…Antioxidants have been widely used as food additives to protect against oxidative degradation by free radicals, and also help to prevent harmful reactive oxygen species in human body (Yim et al 2011). Recently, some natural extracts such as polysaccharides extracted from fungus, bacteria and plant possess antioxidant activity (Xu et al 2011a, b;Tian et al 2011;Wang et al 2011;Waseem et al 2011). But little information is available about the antioxidant activity of the Monascus mycelium polysaccharides, and whether the antioxidant activities of polysaccharides were damaged by alkali extraction is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Alkali extraction and in vitro antioxidant activity of Monascus mycelium polysaccharides

et al. 2012

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In the present work, alkali extraction technology was used to optimize the extraction of Monascus mycelium polysaccharides for the first time. The extracting parameters of alkali extracted Monascus mycelium polysaccharides were optimized by Box-Behnken design (BBD). The optimum conditions were extraction temperature 49°C, alkali concentration 7%, solvent/material ratio 23:1 (ml/g) and extraction time 2.3 h with an enhanced yield of 10.1%, compared with the yield 4.76% of hot water extraction, indicating that alkali extraction is a more efficient way. In order to discuss the biological activity of alkali extracted polysaccharides, we compared the in vitro antioxidant activity of alkali extracted polysaccharides (AMP) with hot water extracted polysaccharides (HMP). The result showed that AMP have the similar capability of scavenging both superoxide radical and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical of HMP in vitro. Therefore, alkali extraction technology is not only a highefficiency way to extract AMP, but also can retain the natural antioxidant activities of AMP, which can be used in pharmaceutical and food industries.

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Bioactive Polysaccharides of Vegetable and Microbial Origins: An Overview

Tommonaro

Poli

Donato

et al. 2015

Handbook of Polymers for Pharmaceutical Technologies

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A comparative study on the antioxidant activities of an acidic polysaccharide and various solvent extracts derived from herbal Houttuynia cordata

Cited by 140 publications

References 28 publications

Characterization, antioxidant activities and hepatoprotective effects of polysaccharides from pre-pressing separationFujiapple peel

Characterization, antioxidant activities and hepatoprotective effects of polysaccharides from pre-pressing separationFujiapple peel

Alkali extraction and in vitro antioxidant activity of Monascus mycelium polysaccharides

Bioactive Polysaccharides of Vegetable and Microbial Origins: An Overview

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