A comparative study on in vitro degradation behavior of PLLA-based copolymer monofilaments

Shi, Daokun; Kang, Yahong; Zhang, Guoyi; Gao, Chenguang; Lu, Wei; Yang, Caihong; Zou, Hua; Jiang, Hongyan

doi:10.1016/j.polymdegradstab.2018.11.005

Cited by 19 publications

(15 citation statements)

References 33 publications

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“…Microscopic cracks would appear locally when water penetrates the fiber surface, and the cracks would gradually expand along the direction with weaker mechanical properties by water tension, finally resulting in macroscopic cracks perpendicular to the fiber axis. 23 Pure PLLA fibers have highly regular molecular chains and poor hydrophilicity, and copolymerization with CL monomer destroyed the structural regularity and crystals; as a result, the surface of PLC15 fibers exhibited micro-cracks earlier than the PLLA15, indicating that the filter part will degrade faster than the connecting fibers.…”

Section: Resultsmentioning

confidence: 99%

Design and evaluation of a novel biodegradable inferior vena cava filter

Yang

Gao

et al. 2019

J Biomater Appl

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Inferior vena cava filter has been increasingly applied in clinical practice to prevent pulmonary embolism. Nowadays, various complications after implanting conventional filters seriously hinder clinical applications. Therefore, in this paper, a novel biodegradable inferior vena cava filter was designed based on biodegradable materials, which is an hourglass-like filter anchored inside a stent structure fixed by connecting fibers. Firstly, mechanical tests in crimp were performed to study the expansion properties of the filter, showing that the biodegradable inferior vena cava filter could achieve self-expansion easily. Furthermore, the biodegradable inferior vena cava filters and fibers were incubated in phosphate buffer media (pH = 7.4 ± 0.2) at 37°C for six months. Scanning electron microscope micrograph showed that the stents exhibited no significant dimensional and structural changes and had enough radial force to support the vessel. During the degradation period, the results of scanning electron microscope, gel permeation chromatography, differential scanning calorimetry and tensile strength analysis confirmed that the degradation rate of the hourglass-like filter was faster than the connecting fibers, achieving progressive degradation and thus avoiding the polymer fragments from blocking vessel. Cytotoxicity and hemolysis assay demonstrated good biocompatibility of the filter. For 5 mm × 10 mm sized thrombus, in vitro simulated thrombus capture test showed that the mean trapping efficiency of the filter was 90%, which was comparable to traditional inferior vena cava filter. In conclusion, all results exhibited that the as-designed biodegradable inferior vena cava filter has a potential in clinical application for patients who are at temporary high risk of venous thromboembolism.

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Section: Resultsmentioning

confidence: 99%

Design and evaluation of a novel biodegradable inferior vena cava filter

Yang

Gao

et al. 2019

J Biomater Appl

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“…To begin with, PLLA monofilament has nearly no mass loss during degradation, which indicates that PLLA monofilament can conserve physical integrity well during the whole degradation period. To further evaluate the degradation rate, the degradation rate constant based on the first-order kinetic model is calculated according to the following equation: 28 ln…”

Section: Degradation Ratementioning

confidence: 99%

“…In short, the degradation of PLLA monofilament in bile mainly follows bulk erosion mechanism because it shows almost negligible mass loss and certain reduction in M w , 28 and the degradation rate is quite slow, conducive to maintaining high mechanical properties.…”

Section: Degradation Ratementioning

confidence: 99%

A poly(L‐lactic acid) monofilament with high mechanical properties for application in biodegradable biliary stents

Tian

Zhang

Cheng

et al. 2020

J of Applied Polymer Sci

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In this article, a poly(L‐lactic acid) (PLLA) monofilament with high mechanical properties which can be used to construct biodegradable biliary stents (BBS) is prepared. Compared with a commercial polydioxanone (PDO) suture, the PLLA monofilament has much higher Young's modulus. As a result, chronic outward force (COF) of the stent braided by PLLA monofilament is more than three times higher than that of the stent braided by PDO suture. Furthermore, by physicochemical indexes characterizations, it is acceptable that the PLLA monofilament has stable Young's modulus and higher elongation at break without brittle fracture risk during degradation in bile. In contrast, although PDO suture can also maintain Young's modulus well during degradation, its elongation at break is attenuated rapidly, which shows a high brittle fracture risk. These results indicate that PLLA monofilament is more suitable for constructing BBS with high COF, which are promising in treating more complex biliary strictures that need longer support time.

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“…Poly(L‐lactic acid) (PLLA), as a typical biodegradable polymer, has been widely investigated in various biomedical fields by virtue of its potential good performance 9–11 . Recently, PLLA as a potential material of BBS has attracted increasing attention, and some theoretical studies on PLLA braided stents are encouraging 12,13 .…”

Section: Introductionmentioning

confidence: 99%

Effects of annealing temperature on both radial supporting performance and axial flexibility of poly(L‐lactic acid) braided stents

Tian

Liu

et al. 2021

J of Applied Polymer Sci

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In this paper, the effects of annealing temperature on both radial supporting performance and axial flexibility of poly(L‐lactic acid) (PLLA) braided stents are studied. Stents are annealed at a series of temperatures ranging from 80 to 160°C for 1 h, then indicators of shaping effect, radial supporting performance, and axial flexibility are compared. Stents not annealed and annealed at 80°C cannot be completely shaped. In contrast, stents annealed at 100 to 160°C are well shaped showing radial shrinkage rate of 1.0 ± 0.2% and almost no axial elongation. The radial compressive force and axial force are gradually increased by 51.2% and 89.2%, respectively with the annealing temperature gradually increasing from 80 to 160°C, indicating that the radial supporting performance is improved but axial flexibility is weakened by a higher annealing temperature. Taken together, PLLA braided stents can be annealed at 100 to 120°C to obtain sufficient radial force and lower axial force simultaneously for clinical applications. Moreover, tensile test, X‐ray diffraction, and differential scanning calorimetry are performed for monofilaments annealed at different temperatures to further explore the effect mechanism of annealing temperature on the mechanical properties of stents. This study may provide helpful suggestions for the manufacture of biodegradable braided stents.

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A comparative study on in vitro degradation behavior of PLLA-based copolymer monofilaments

Cited by 19 publications

References 33 publications

Design and evaluation of a novel biodegradable inferior vena cava filter

Design and evaluation of a novel biodegradable inferior vena cava filter

A poly(L‐lactic acid) monofilament with high mechanical properties for application in biodegradable biliary stents

Effects of annealing temperature on both radial supporting performance and axial flexibility of poly(L‐lactic acid) braided stents

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