BackgroundThe purpose of the animal study is to introduce a newly designed hinged plate and screw system for correction of angular deformities of the lower limbs. The technique was compared with the use of a conventional tension-band plate and screw system.MethodsThis is a randomized controlled animal trial. Eight 3-month-old Bama miniature pigs were used to establish animal models. In each animal, one leg was randomly allocated into study group and another leg into control group. Legs of the study group were corrected with a hinged plate and screw system, and legs of the control group were corrected with a conventional tension-band plate and screw system. The corrective rates of medial slope angle, medial proximal tibial angle, and angle of the two arms of the hinged plate were measured. Residual stress on the implants was also evaluated. A P < 0.05 was statistical significant.ResultsAt the final measurements of 18 weeks, the mean corrective rates of medial slope angle, medial proximal tibial angle, and angle of the two arms of the study group were 0.71°/week, 0.85°/week, and 2.18°/week, respectively; the data in the control group were 0.84°/week, 0.89°/week, and 2.13°/week, respectively. No significant difference was found between the groups regarding the mean corrective rates of the angles (P < 0.05). The mean residual stress in the study group was 643.35 MPa, and measurement in the control group was 1,273.63 MPa, with a significant difference (P < 0.05).ConclusionsCompared to the conventional tension-band plate and screw system, the hinged plate and screw system may be more reliable for correction of angular deformities of the lower limb.
Lacking osseointegration and peri-implantitis induced by bacterial infiltration are the pivotal issues for the long-term clinical success of implants. In order to improve the bioactivity and antibacterial properties of implant materials, volcano-shaped microporous TiO2 coatings doped with Zinc (Zn) were fabricated via a micro-arc oxidation (MAO) method on pure titanium (Ti). The microstructure, morphology, and chemical composition of the Zn-doped coatings were systematically studied. In cell culture tests, the formed coatings promoted the adhesion and proliferation of bone mesenchymal stem cells (BMSCs), exhibiting good biocompatibility. The antibacterial experiments revealed that Zn-TiO2 coatings possess excellent antibacterial properties against Staphylococcus aureus (S. aureus) and Porphyromonas gingivalis (P. gingivalis).
Inferior vena cava filter has been increasingly applied in clinical practice to prevent pulmonary embolism. Nowadays, various complications after implanting conventional filters seriously hinder clinical applications. Therefore, in this paper, a novel biodegradable inferior vena cava filter was designed based on biodegradable materials, which is an hourglass-like filter anchored inside a stent structure fixed by connecting fibers. Firstly, mechanical tests in crimp were performed to study the expansion properties of the filter, showing that the biodegradable inferior vena cava filter could achieve self-expansion easily. Furthermore, the biodegradable inferior vena cava filters and fibers were incubated in phosphate buffer media (pH = 7.4 ± 0.2) at 37°C for six months. Scanning electron microscope micrograph showed that the stents exhibited no significant dimensional and structural changes and had enough radial force to support the vessel. During the degradation period, the results of scanning electron microscope, gel permeation chromatography, differential scanning calorimetry and tensile strength analysis confirmed that the degradation rate of the hourglass-like filter was faster than the connecting fibers, achieving progressive degradation and thus avoiding the polymer fragments from blocking vessel. Cytotoxicity and hemolysis assay demonstrated good biocompatibility of the filter. For 5 mm × 10 mm sized thrombus, in vitro simulated thrombus capture test showed that the mean trapping efficiency of the filter was 90%, which was comparable to traditional inferior vena cava filter. In conclusion, all results exhibited that the as-designed biodegradable inferior vena cava filter has a potential in clinical application for patients who are at temporary high risk of venous thromboembolism.
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