A comparative study on efficacy of <scp>UVA1</scp> vs. narrow‐band <scp>UVB</scp> phototherapy in the treatment of vitiligo

El-Zawahry, Bakr Mohamed; Bassiouny, Dalia Ahmed; Sobhi, Rehab Mohamed; Abdelaziz, Eman Z.; Zaki, Naglaa Sameh; Habib, Dawoud Fakhry; Shahin, Dalia Mamdouh

doi:10.1111/j.1600-0781.2011.00643.x

Cited by 30 publications

(30 citation statements)

References 29 publications

(35 reference statements)

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“…A total of seven RCTs involving 232 participants with vitiligo were included in this systematic review. Three studies focused on European population (16)(17)(18), two studies focused on African population (12,13) and two studies focused on Asian population (14,15).…”

Section: Study Characteristic and Quality Assessmentmentioning

confidence: 99%

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Treatment of vitiligo with NB-UVB: A systematic review

Xiao

Sun

et al. 2014

Journal of Dermatological Treatment

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Section: Study Characteristic and Quality Assessmentmentioning

confidence: 99%

“…Then, corporated review excluded five studies not reporting the number of patients who achieved450,460 or475% re-pigmentation, and five studies not providing adequate and detailed statistics. Finally, seven RCTs were reserved and included in the study (12)(13)(14)(15)(16)(17)(18). The procedure was illustrated in Figure 1.…”

Section: Eligible Studiesmentioning

confidence: 99%

Treatment of vitiligo with NB-UVB: A systematic review

Xiao

Sun

et al. 2014

Journal of Dermatological Treatment

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“…In a prospective, randomized-controlled comparative clinical trial [94], 20 patients received NB-UVB and 20 received UVA1 three times weekly for 12 weeks of medium-dose or low-dose UVA1. NB-UVB was found to be superior to UVA1, with a significant difference in the blinded dermatological assessment (Po0.001) and in the percentage change in the vitiligo area scoring index score (Po0.001).…”

Section: Ultraviolet A1mentioning

confidence: 99%

Phototherapy in vitiligo

El‐Mofty¹,

Mostafa²,

Esmat³

et al. 2012

Journal of the Egyptian Womenʼs Dermatologic Society

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Phototherapy is the backbone of vitiligo treatment. Besides the use of heliotherapy since ancient times, artificial sources have been introduced for the last decades in different wavelengths and administration devices utilizing a multitude of regimens and treatment combinations. In this article, we present a comprehensive compilation of the use of different modalities of phototherapy in vitiligo on the basis of a multitude of related comparative studies that have been carried out during the last decade, including those performed at the Phototherapy Unit, Kasr Al Aini Hospital. The phototherapeutic modality most commonly utilized in the treatment of vitiligo at present is narrowband ultraviolet B (NB-UVB) (311 nm), although in our area, photochemotherapy still continues to be used. Efforts have been made to take into account most comparative studies including the different combinations of NB-UVB with other modalities. The different types of psoralens used in photochemotherapy are discussed, besides comparison of the use of various ultraviolet light sources in vitiligo. The results of studies comparing both psoralen plus ultraviolet A and NB-UVB are also included. A more recently emerging phototherapeutic modality in the treatment of vitiligo and other photoresponsive dermatoses is broadband UVA, which awaits shortterm and long-term safety evaluation studies, both clinical and laboratory. Diverse tools yielding targeted phototherapy are widely being used nowadays in the treatment of vitiligo. Systems range from laser to incoherent pointed light equipment to larger but localized sources, all aiming at sparing the unaffected skin undue radiation exposure.

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“…Like other emission spectra of ultraviolet radiation, UVA1 has immunosuppressive effects which help to reduce autoimmune condition that leads melanocyte destruction. UVA1 can induce apoptosis in skin infiltrating leukocytes; suppress proinflammatory cytokines like TNF-α and IL-12, decrease level of IFN-Ƴ and ICAM [65]. Superior to other phototherapy options, UVA1 is relatively free of side effects like erythema and cellular transformation.…”

Section: Uvamentioning

confidence: 99%

“…In a recent randomized controlled study, El-Zawahry et al compared UVA1 and NB UVB therapy in the treatment of vitiligo. They emphasized that NB UVB was superior to UVA1 which seems to be dose dependent and seems to be of limited value in treatment of vitiligo as a monotherapy [65] …”

Section: Uvamentioning

confidence: 99%

Photo (Chemo) Therapy and Vitiligo

2015

J Turk Acad Dermatol

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Background: Vitiligo is an acquired idiopathic pigmentary skin disorder characterized by sharply demarcated milky white macules with variable size and shape. It has an estimated worldwide incidence of 0.5-4% and occurs in half of the patients before the age of 20 years. Since exact pathogenic mechanism is unknown, several proposed hypotheses are alternation of cellular and humoral immunity, melanocyte damage stimulated by chemicals released from nerve endings, structural aberration of melanocytes, melanocytorrhagia, epidermal cytokines, metabolic dysregulations and convergence theory depended on combination of these etiologic factors. Treatment of vitiligo depends on viable melanocyte reservoirs which induce repigmentation during various therapies. Although melanocyte reservoir mainly shown as hair follicle unit, repigmentation arise from three main sources. These are hair follicle unit, melanocytes located at the edge of vitiligo lesion and unaffected melanocytes within areas of depigmented epidermis. Treatment modalities for vitiligo therapy divided in three main groups as medical therapy, phototherapy and surgical therapy. Vitiligo lesions should be initially treated with topical medical therapy or localized phototherapy. If depigmentation is larger than 10-20% of body surface area, systemic medical therapy or phototherapy should be sought. When depigmentations do not regress in spite of appropriate interventions, surgical therapies should be considered as the lesions become refrectory and stable. In this review, we discuss the literature and evidence base for phototherapy in vitiligo and summarized previous studies.

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A comparative study on efficacy of UVA1 vs. narrow‐band UVB phototherapy in the treatment of vitiligo

Cited by 30 publications

References 29 publications

Treatment of vitiligo with NB-UVB: A systematic review

Treatment of vitiligo with NB-UVB: A systematic review

Phototherapy in vitiligo

Photo (Chemo) Therapy and Vitiligo

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