2012
DOI: 10.1111/j.1600-0781.2011.00643.x
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A comparative study on efficacy of UVA1 vs. narrow‐band UVB phototherapy in the treatment of vitiligo

Abstract: NB-UVB phototherapy remains to be an effective and safe therapeutic option in vitiligo. Response to UVA1 in vitiligo seems to be dose dependent and seems to be of limited value in treatment of vitiligo as a monotherapy. Further studies combining it with other lines of therapy such as systemic steroids may prove beneficial.

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Cited by 30 publications
(30 citation statements)
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“…A total of seven RCTs involving 232 participants with vitiligo were included in this systematic review. Three studies focused on European population (16)(17)(18), two studies focused on African population (12,13) and two studies focused on Asian population (14,15).…”
Section: Study Characteristic and Quality Assessmentmentioning
confidence: 99%
See 1 more Smart Citation
“…A total of seven RCTs involving 232 participants with vitiligo were included in this systematic review. Three studies focused on European population (16)(17)(18), two studies focused on African population (12,13) and two studies focused on Asian population (14,15).…”
Section: Study Characteristic and Quality Assessmentmentioning
confidence: 99%
“…Then, corporated review excluded five studies not reporting the number of patients who achieved450,460 or475% re-pigmentation, and five studies not providing adequate and detailed statistics. Finally, seven RCTs were reserved and included in the study (12)(13)(14)(15)(16)(17)(18). The procedure was illustrated in Figure 1.…”
Section: Eligible Studiesmentioning
confidence: 99%
“…In a prospective, randomized-controlled comparative clinical trial [94], 20 patients received NB-UVB and 20 received UVA1 three times weekly for 12 weeks of medium-dose or low-dose UVA1. NB-UVB was found to be superior to UVA1, with a significant difference in the blinded dermatological assessment (Po0.001) and in the percentage change in the vitiligo area scoring index score (Po0.001).…”
Section: Ultraviolet A1mentioning
confidence: 99%
“…Like other emission spectra of ultraviolet radiation, UVA1 has immunosuppressive effects which help to reduce autoimmune condition that leads melanocyte destruction. UVA1 can induce apoptosis in skin infiltrating leukocytes; suppress proinflammatory cytokines like TNF-α and IL-12, decrease level of IFN-Ƴ and ICAM [65]. Superior to other phototherapy options, UVA1 is relatively free of side effects like erythema and cellular transformation.…”
Section: Uvamentioning
confidence: 99%
“…In a recent randomized controlled study, El-Zawahry et al compared UVA1 and NB UVB therapy in the treatment of vitiligo. They emphasized that NB UVB was superior to UVA1 which seems to be dose dependent and seems to be of limited value in treatment of vitiligo as a monotherapy [65] …”
Section: Uvamentioning
confidence: 99%