A Comparative Study on Clinical Evaluation of the Hypolipidemic Effects of Allium sativum, Trigonella foenum-graecum, Commiphora mukul, Picrorhiza kurroa, and Piper nigrum: A Pilot Study

Abstract

BackgroundCardiovascular disease is a leading cause of morbidity and mortality. Therefore, it is essential to prevent cardiovascular diseases by correcting modifiable risk factors such as lowering lipid levels, lowering blood pressure, improving eating habits, giving up smoking, etc. The present study assessed the efficacy of herbal preparation containing Allium sativum (A. sativum), Commiphora mukul (C. mukul), and Trigonella foenum-graecum (T. foenum-graecum) in patients with hyperlipidemia. MethodologyPatients were given extracts of A. sativum 350 mg, T. foenum-graecum 350 mg, C. mukul 200 mg, Picrorhiza kurroa (P. kurroa) 200 mg, and Piper nigrum (P. nigrum) 5 mg. Unichem Laboratories, Mumbai, provided placebo tablets similar in shape and size to herbal tablets. Patients were assessed for compliance, and a complete lipid profile was done at DO, D15, D46, D76, and D106. In addition, total cholesterol and highdensity lipoprotein-cholesterol (HDL-C) serum triglyceride were estimated by the respective methods throughout the study. ResultsThe weight of the patients remained stable, the mean weight before being 65.42 ± 8.35 kg and after completion of the study being 65.42 ± 8.35 kg. There were no changes in the ECG during or after the drug therapy in any of the patients. Group A comprised nine patients, and group B had ten patients. Serum creatinine (mg %) was 0.94 and 0.95, fasting blood sugar mg (%) was 111.05 and 99.63, and postprandial blood sugar (mg %) was 150.89 and 147.94 on pre-treatment and post-treatment, respectively. The mean serum triglyceride levels in group

Preventive effects of <i>Trigonella foenum-graecum</i> and <i>Allium sativum</i> against Triton induced hyperlipidaemia in rabbits

“…Nowadays, herbal medicines are the most popular forms of alternative medicine. They have multiple effects in that some plants or plant products not only having antidiabetic effects, but have also shown a reduction in blood fat [24,25].…”

Homeopathic preparation of Allium sativum abrogates OxLDL mediated atherogenic events in macrophages: An in vitro and in silico approach

“…One such promising approach is homeopathy, which is widely used to treat many diseases, including dyslipidemia [ 9 ] at extreme dilutions, deeming it safe. Recently, Allium sativum , a common ingredient in many cuisines has been referred to as anti-atherogenic [ 10 ], anti-inflammatory [ 11 , 12 ], and hypo-lipidemic [ 13 , 14 ], but its homeopathic medicine should be validated scientifically. Hence, this study was designed to investigate the modus operandi of the homeopathic preparation of Allium sativum for curbing OxLDL-mediated cellular inflammation in IC-21 cells exposed to OxLDL.…”