A comparative study of toxic erythema of pregnancy and herpes gestationis

Abstract

We compared the clinical features, histopathology, immunopathology and immunogenetics of 30 patients with toxic erythema of pregnancy and 24 patients with herpes gestationis. Although we found some clinical and histopathological overlap we highlighted several important differences. In toxic erythema of pregnancy prominent striae were frequently present. Herpes gestationis was suggested by the occurrence of periumbilical lesions, acute exacerbations immediately after delivery, and persistence of the eruption for more than 3 weeks post-partum. In herpes gestationis, immunofluorescence studies were consistently positive, there was a high frequency of HLA-B8 and an association with autoimmune thyrotoxicosis. Toxic erythema of pregnancy did not share these immunological features. Therefore we feel that toxic erythema of pregnancy and herpes gestationis should continue to be classified as separate disorders.

The specific dermatoses of pregnancy revisited and reclassified: Results of a retrospective two-center study on 505 pregnant patients

“…Sixteen of these had been referred by other hospitals or dermatologists, which explains the unusually high number of cases in this patients' series, as the incidence of PG is very low, estimated at approximately 1 in 50,000 pregnancies. 13 Ten patients (48%) were primigravidae and all had a single gestation pregnancy. One of Table I.…”

Pemphigoid gestationis: A Moroccan study

“…Linear IgG positivity is also detected in about 25-50% of the samples, but it is not a criterion for the diagnosis [18][19][20].…”

A view of the problem of pregnancy-specific skin dermatoses. Part I

“…: токсемическая сыпь беременных, токсическая эритема беременных), за-тем пруригинозный фолликулит беременных и вну-трипеченочный холестаз беременных. Пруриго бе-ременных Бенье, пруригинозный фолликулит бере-менных и атопический дерматит были объединены в группу «Атопическая сыпь беременных», так как главные клинические и патогистологические при-знаки их были идентичны [19][20][21][22][23][24][25].…”