A comparative study of tissue-engineered constructs from <i>Acropora</i> and <i>Porites</i> coral in a large animal bone defect model

Decambron, Adeline; Bensidhoum, Morad; Lecuelle, Benoit; Logeart-Avramoglou, Delphine; Petite, Hervé; Viateau, Véronique

doi:10.1302/2046-3758.64.bjr-2016-0236.r1

Cited by 17 publications

(15 citation statements)

References 23 publications

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“…Data also suggests that the tissue-engineered constructs with MSCs (either genetic modified or not) brings us closer to a clinical application. However, nonunion still occurred in nearly half of the bone defects in a large animal model [25]. In fact, the commonly accepted idea that atrophic nonunion is due to lack of MSCs activities of MSCs might be not accurate.…”

Section: Mscs In Nonunion Bone Fracturementioning

confidence: 99%

Clinical Applications of Mesenchymal Stromal Cells (MSCs) in Orthopedic Diseases

Yang¹,

Fang²,

Xu³

et al. 2019

Stromal Cells - Structure, Function, and Therapeutic Implications

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Mesenchymal stromal cells (MSCs) have the capacity for self-renewal and multi-lineage differentiation, have many advantages over other cells, and are thought to be one of the most promising cell sources for cell-based treatments. In fact, MSCs have already been widely applied in clinics as a treatment for numerous disorders, including orthopedic diseases, such as bone fracture, articular cartilage injury, osteoarthritis (OA), femoral head necrosis, degenerative disc, meniscus injury, osteogenesis imperfecta (OI), and other systemic bone diseases. With the progressions in R&D, the safety and efficacy of MSC-based treatments in orthopedic diseases have been largely recognized, but many challenges still exist. In this chapter, we intend to briefly update the recent progressions and discuss the potential issues in the target areas. Hopefully, our discussion would be helpful not only for the clinicians and the researchers in the specific disciplines but also for the general audiences.

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Section: Mscs In Nonunion Bone Fracturementioning

confidence: 99%

Clinical Applications of Mesenchymal Stromal Cells (MSCs) in Orthopedic Diseases

Yang¹,

Fang²,

Xu³

et al. 2019

Stromal Cells - Structure, Function, and Therapeutic Implications

View full text Add to dashboard Cite

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“…Bone tissue has a certain ability to regenerate. However, large bone defect repairs and complex fracture treatment still present a significant challenge . Moreover, the increasingly aged population has resulted in the requirement for effective therapies for osteoporosis.…”

Section: Hydrogel Scaffold For Regenerative Medicinementioning

confidence: 99%

Hydrogels as Emerging Materials for Translational Biomedicine

Ke-min

Wang

Yong

et al. 2018

Advanced Therapeutics

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Hydrogels have been extensively investigated as biomaterials because of their excellent biocompatibility, and recent developments such as 3D printing and the incorporation of dynamic crosslinks have advanced the field considerably. However, the next step of in vivo translational biomedicine requires an understanding of essential hydrogel properties so that they can be designed to overcome the challenges of the living environment. In this review, the stringent design criteria required for in vivo applications are highlighted and recent advances in the repair of organ tissues (heart, bone, eye, etc.) and the therapeutic delivery of bioactive molecules are described. Commercially available hydrogel systems that can be used for translational biomedicine are also discussed, as is the long and sometimes fraught journey from the laboratory to the clinic.The question then arises whether the next iteration of hydrogels can be designed for long-term applications in an in vivo environment with all its complicating agents and factors, and issues such as biodistribution and immune responses. [27][28][29][30] Hydrogels could be prone to dissociation by high shear forces, or the responsiveness to stimuli could be much less sensitive within the body. [31][32][33][34] In this review, we discuss the design of hydrogels for in vivo applications, including for use clinically and commercially. This is not a comprehensive review of the entire field of translational hydrogels, but concentrates on promising results in animal trials. The reader is referred to several reviews which offer a different perspective and provide more detailed information on injectable hydrogels, regenerative scaffolds, and therapeutic delivery. [2,11,24,[35][36][37][38][39]

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“…The authors concluded that the presence of MSCs is beneficial for osteoinductive behaviour. A comparation between Acropora or Porite coral granules combined with MSCs for their potential use in bone regeneration was performed by Decambron et al [ 156 ]. The cells were seeded on both types of coral granules, placed in a perfusion bioreactor, and then implanted into bone defects in sheep.…”

Section: Marine-derived Bioceramics As Scaffolds For Bone Tissue Ementioning

confidence: 99%

Synthetic and Marine-Derived Porous Scaffolds for Bone Tissue Engineering

Neto

Ferreira

2018

Materials

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Bone is a vascularized and connective tissue. The cortical bone is the main part responsible for the support and protection of the remaining systems and organs of the body. The trabecular spongy bone serves as the storage of ions and bone marrow. As a dynamic tissue, bone is in a constant remodelling process to adapt to the mechanical demands and to repair small lesions that may occur. Nevertheless, due to the increased incidence of bone disorders, the need for bone grafts has been growing over the past decades and the development of an ideal bone graft with optimal properties remains a clinical challenge. This review addresses the bone properties (morphology, composition, and their repair and regeneration capacity) and puts the focus on the potential strategies for developing bone repair and regeneration materials. It describes the requirements for designing a suitable scaffold material, types of materials (polymers, ceramics, and composites), and techniques to obtain the porous structures (additive manufacturing techniques like robocasting or derived from marine skeletons) for bone tissue engineering applications. Overall, the main objective of this review is to gather the knowledge on the materials and methods used for the production of scaffolds for bone tissue engineering and to highlight the potential of natural porous structures such as marine skeletons as promising alternative bone graft substitute materials without any further mineralogical changes, or after partial or total transformation into calcium phosphate.

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A comparative study of tissue-engineered constructs from Acropora and Porites coral in a large animal bone defect model

Cited by 17 publications

References 23 publications

Clinical Applications of Mesenchymal Stromal Cells (MSCs) in Orthopedic Diseases

Clinical Applications of Mesenchymal Stromal Cells (MSCs) in Orthopedic Diseases

Hydrogels as Emerging Materials for Translational Biomedicine

Synthetic and Marine-Derived Porous Scaffolds for Bone Tissue Engineering

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