A Comparative Study of the Different Doses of Magnesium Sulphate and Fentanyl as Adjuvants to Bupivacaine [0.5% Heavy] for Lower Abdominal Surgeries Under Subarachnoid Block

Aasim, Syed Ali; Reddy, Srikanth; Reddy, Maheshwar; Kumar, Ashwani; Vishnu, Vishnu; Rao, Sanjeev; Mohammed, Shakeeb

doi:10.14260/jemds/2016/409

jemds

2016

DOI: 10.14260/jemds/2016/409

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A Comparative Study of the Different Doses of Magnesium Sulphate and Fentanyl as Adjuvants to Bupivacaine [0.5% Heavy] for Lower Abdominal Surgeries Under Subarachnoid Block

Syed Ali Aasim¹,

Srikanth Reddy²,

Maheshwar Reddy³

et al.

Abstract: BACKGROUNDSpinal anaesthesia is the most commonly used technique for infraumbilical surgeries and it has some disadvantages, such as a short duration of motor blockade and post-operative analgesia. This study was designed to evaluate the effects of additive agents of fentanyl and magnesium sulphate along with Bupivacaine for prolongation of analgesia and motor blockade during spinal anaesthesia for infraumbilical surgeries.

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2023

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Comparison of Subarachnoid Magnesium Sulfate and Fentanyl as Adjuvants With 0.5% Heavy Bupivacaine for Postoperative Analgesia in Infra-Umbilical Surgeries

Kaur¹,

Rizvi²,

Srivastava³

et al. 2023

Asian J Pharm Clin Res

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Objectives: The objective of the study was to compare the efficacy of adjuvant use of subarachnoid fentanyl with the adjuvant use of subarachnoid magnesium sulfate as adjuvants to bupivacaine in subarachnoid block for infraumbilical surgeries in terms of: (1) Block characteristics, namely, time taken for onset of block and time taken for regression of block, (2) Hemodynamic stability in intra- and post-operative phase. Methods: A total of 70 ASA I/II patients scheduled for infra-umbilical surgery were enrolled in the study and were randomized either to Group F (0.5 mL Fentanyl+3 mL 0.5% Bupivacaine) (n=35) or to Group M (0.5 mL 20% Magnesium sulfate+3 mL 0.5% Bupivacaine). Time to achieve onset of block, duration of block. Data were analyzed using the Chi-square and Independent samples, t’-test. Results: Age of patients ranged from 18 to 55 years. The two groups were matched onset of sensory and motor block was significantly earlier in Magnesium sulfate group as compared to fentanyl group. Regression of motor and sensory block was significantly earlier in group where magnesium sulfate was used as an additive in contrast to fentanyl. No other complication except nausea (8.6%) and bradycardia (8.6%) was reported in any of the patient. Conclusion: Although magnesium sulfate appears to be a relatively safer alternative than fentanyl for adjuvant use with hyperbaric bupivacaine for post-operative pain management and to facilitate better block characteristics; however, it fails to achieve the analgesic effect even comparable to fentanyl. Further studies with inclusion of a control group and with changed drug–dose combinations are recommended to find out a better alternative.

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Comparison of Subarachnoid Magnesium Sulfate and Fentanyl as Adjuvants With 0.5% Heavy Bupivacaine for Postoperative Analgesia in Infra-Umbilical Surgeries

Kaur¹,

Rizvi²,

Srivastava³

et al. 2023

Asian J Pharm Clin Res

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A Comparative Study of the Different Doses of Magnesium Sulphate and Fentanyl as Adjuvants to Bupivacaine [0.5% Heavy] for Lower Abdominal Surgeries Under Subarachnoid Block

Cited by 1 publication

References 11 publications

Comparison of Subarachnoid Magnesium Sulfate and Fentanyl as Adjuvants With 0.5% Heavy Bupivacaine for Postoperative Analgesia in Infra-Umbilical Surgeries

Comparison of Subarachnoid Magnesium Sulfate and Fentanyl as Adjuvants With 0.5% Heavy Bupivacaine for Postoperative Analgesia in Infra-Umbilical Surgeries

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