A Comparative Study of the Effects of Intrathecal Midazolam and Fentanyl as Additives to Intrathe Cal Hyperbaric Bupivacaine (0.5 %) for Lower Abdominal Surgeries

Aasim, Syed Ali; Reddy, Vishnuvardhan; M, Anil K; Reddy, Maheshwar; Mahesh, M.

doi:10.18410/jebmh/2015/1241

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…Syed Ali Aasim et al 32 in 2015 compared the analgesic efficacy and safety of intrathecal midazolam(1mg) and fentanyl (25 µg) as an additive agent to bupivacaine for lower abdominal elective surgeries and concluded that midazolam is as effective as fentanyl in prolonging the durations of both sensory block and analgesia with less side effects like hypoxia, hypotension, bradycardia or respiratory depression. Six patients (30%) complained of pruritus in the fentanyl group while no one in other (p <0.01).…”

Section: Discussionmentioning

confidence: 99%

Comparative study of intrathecal fentanyl with bupivacaine and fentanyl midazolam with bupivacaine in spinal anaesthesia

Mehta¹,

Khan²,

Shah³

2021

IJCA

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Spinal anaesthesia is preferred for lower abdominal and lower limb surgeries. Bupivacaine is the most popular local anaesthetic for subarachnoid blockade because of less neurotoxicity. Intrathecal bupivacaine alone may be insufficient to provide prolonged post-operative analgesia, even with high sensory block. So, various adjuvants are used like ketamine, midazolam, clonidine, opioids, neostigmine etc. to prolong the effect of local anaesthetic.To compare the effect of intrathecal fentanyl and fentanyl-midazolam combination with hyperbaric bupivacaine for quality of anaesthesia and post-operative analgesia.Study was conducted on 60 patients aged 20-60 years and were randomly divided into two groups of 30 patients each. Group A received 0.5% bupivacaine heavy 3 ml (15mg) + fentanyl 0.5 ml (25µg) and Group B 0.5% bupivacaine heavy 2.8 ml (14mg) +fentanyl 0.5 ml (25 µg) + midazolam 0.2 ml (1mg). Total volume is 3.5 ml in both groups. They were assessed for quality of block, post-operative analgesia and perioperative complications.Data were compared using t- test(unpaired). The level of significance used was p<0.05. There was a significant difference in onset and duration of sensory and motor block, time to administer first rescue analgesia in group B. Addition of midazolam (1mg) to fentanyl with bupivacaine intrathecally gives better onset & duration of sensory & motor blockade and longer duration of post-operative analgesia.

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Section: Discussionmentioning

confidence: 99%

Comparative study of intrathecal fentanyl with bupivacaine and fentanyl midazolam with bupivacaine in spinal anaesthesia

Mehta¹,

Khan²,

Shah³

2021

IJCA

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Comparison of Fentanyl With Midazolam As Adjuvants to Levobupivacaine in Spinal Anesthesia for Cesarean Sections: A Randomized Controlled Trial

Yazhini,

Venkatraman,

Kandan

2024

Cureus

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Background and objectivesSpinal anesthesia stands as a cornerstone for patients undergoing lower segment cesarean section (LSCS), offering advantages like faster onset and high block density. Levobupivacaine, known for its high potency and long-acting nature, has a slower onset. The safety of intrathecal fentanyl or midazolam is evaluated as an adjuvant to levobupivacaine in parturients. This study aims to compare the duration of postoperative analgesia provided by fentanyl or midazolam added to 0.5% hyperbaric levobupivacaine in elective cesarean sections. Secondary objectives include evaluating the onset and duration of sensory and motor blockade and the incidence of nausea and vomiting. Identifying the more effective adjuvant will help optimize spinal anesthesia protocols, improve postoperative outcomes, and enhance patient comfort and recovery. Methods

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A Comparative Study of the Effects of Intrathecal Midazolam and Fentanyl as Additives to Intrathe Cal Hyperbaric Bupivacaine (0.5 %) for Lower Abdominal Surgeries

Cited by 2 publications

References 5 publications

Comparative study of intrathecal fentanyl with bupivacaine and fentanyl midazolam with bupivacaine in spinal anaesthesia

Comparative study of intrathecal fentanyl with bupivacaine and fentanyl midazolam with bupivacaine in spinal anaesthesia

Comparison of Fentanyl With Midazolam As Adjuvants to Levobupivacaine in Spinal Anesthesia for Cesarean Sections: A Randomized Controlled Trial

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