A comparative study of the effects of platelet-rich fibrin, concentrated growth factor and platelet-poor plasma on the healing of tooth extraction sockets in rabbits

Li, Siying; Yang, Hongyi; Duan, Qinyu; Bao, Hongyu; Li, Aodi; Li, Wei; Chen, Junliang; He, Yun

doi:10.1186/s12903-022-02126-0

Cited by 11 publications

(13 citation statements)

References 45 publications

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“…T2DM can interfere with and hinder the healing of extraction sockets by inhibiting osteogenesis differentiation of mesenchymal stem cells [ 22 ]. Although extensive studies revealed that local medication treatment effectively promoted bone regeneration, few studies have clarified their potential application in diabetic tooth extraction sockets [ 23 , 24 ]. It might be due to chronic system inflammation in diabetes restricting medicine’s efficacy.…”

Section: Discussionmentioning

confidence: 99%

Artesunate-loaded thermosensitive chitosan hydrogel promotes osteogenesis of maxillary tooth extraction through regulating T lymphocytes in type 2 diabetic rats

Luo,

Liang,

Chen

et al. 2024

BMC Oral Health

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Background Type 2 diabetes mellitus (T2DM) causes severe bone loss after tooth extraction as a hyperglycemic environment causes aberrant bone homeostasis. Artesunate (ART) is known to possess anti-inflammation and osteogenic properties. However, its osteogenesis property in alveolar bone remains unclear. This study aimed to explore the osteogenic and immunoregulatory effects of artesunate-loaded thermosensitive chitosan hydrogel (ART-loaded TCH) on maxilla tooth extraction in T2DM rats. Methods T2DM rats were induced by a high-fat diet and streptozotocin. Different concentrations of ART-loaded TCH were applied in tooth extraction sockets. Bone loss and the expression of osteogenic regulatory factors (OPG, ALP, RANK) were evaluated. The immunoregulatory effects of ART-loaded TCH were observed through detecting the infiltration of T lymphocytes and their cytokines. The underlying mechanisms were explored. Results Results showed that the 150 mg/ml ART-loaded TCH group significantly ameliorated maxilla bone height and bone mineral density when compared with the T2DM group (p < 0.05). It also improved the expression of OPG, ALP, and RANK. Although the alteration of CD4+ T, CD8+ T, and CD4+:CD8+ T ratio has no significant difference among groups, the release of Th1 and Th2 in the 150 mg/ml ART-loaded TCH group has been significantly regulated than in the T2DM group (p < 0.05). Besides, ART-loaded TCH treatment inhibited the expression of p38 MAPK and ERK1 in T2DM maxilla. Conclusions Therefore, the results indicated that 150 mg/ml ART-loaded TCH could be an effective method to prevent bone loss in T2DM tooth extraction rats by modulating the immunoregulation of Th1 and Th2 and the MAPK signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Artesunate-loaded thermosensitive chitosan hydrogel promotes osteogenesis of maxillary tooth extraction through regulating T lymphocytes in type 2 diabetic rats

Luo,

Liang,

Chen

et al. 2024

BMC Oral Health

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“…Compared to PRF, CGF contains a denser and richer growth factor-brin matrix. Furthermore, CGF has a 3D brin network in which growth factors bind to each other [11,12] . This network provides a slow release of growth factors, facilitating wound healing [12,33,34] .…”

Section: Discussionmentioning

confidence: 99%

Efficacy of concentrated growth factors for tympanic membrane perforation: a study in guinea pigs

Hanari,

Okada,

Nakata

et al. 2023

Preprint

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Concentrated growth factors (CGF) are complexes comprising a fibrin matrix that incorporates growth factors, plasma, and leukocyte cytokines. Here, we investigated the effectiveness of CGF as a tympanic membrane regeneration therapy in a guinea pig eardrum perforation model. Large tympanic membrane perforations (TMPs) were created in 34 ears of 17 guinea pigs. The ears were divided into the CGF, saline, and control groups. On day 14, considerable differences in perforation closure were observed among the CGF, saline, and control groups. On day 28, the ratio of closure was not considerable between the CGF and saline groups, whereas it was substantially higher in the CGF group than in the control group. Histological observations using hematoxylin and eosin staining showed that the regenerated tympanic membrane was thicker in the CGF group than in the saline group, and the regeneration of the fibrous layer was remarkable in the CGF group than that in the saline group. The results suggest that CGF induces tympanic membrane regeneration and can be used to treat TMPs conservatively.

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“…In summary, the application of PPP, CGF, and PRF in the tooth extraction socket effectively promoted bone regeneration. In the long-term, CGF exhibited more potent osteoinductive and tissue regeneration capacities compared with the control 139 (Tables 5 and 6).…”

Section: Rabbit Modelmentioning

confidence: 98%

“…As shown in Figure 3C, Zhang et al illustrate the process of predictable alveolar bone augmentation and synchronized dental implantation by the PLGA/HA/β‐TCP composite scaffold 109 . Li et al 139 selected 24 New Zealand rabbits aged 8–12 weeks that were randomly assigned to four groups: the three experimental groups received PPP, CGF, and PRF gel implantation after bilateral mandibular anterior tooth extraction, while for the control group, no material was implanted. In summary, the application of PPP, CGF, and PRF in the tooth extraction socket effectively promoted bone regeneration.…”

Section: Implantation Defect Models (Include Alveolar Ridge Expansion...mentioning

confidence: 99%

Oral hard tissue defect models for evaluating the regenerative efficacy of implant materials

Sun

Heng

Zhang

2023

MedComm – Biomaterials and Applications

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Oral hard tissue defects are common concomitant symptoms of oral diseases, which have poor prognosis and often exert detrimental effects on the physical and mental health of patients. Implant materials can accelerate the regeneration of oral hard tissue defects (such as periodontal defects, alveolar bone defects, maxilla bone defects, mandible bone defects, alveolar ridge expansion, and site preservation), but their regenerative efficacy and biocompatibility need to be preclinically validated in vivo with animal‐based oral hard tissue defect models. The choice of oral hard tissue defect model depends on the regenerative effect and intended application of the tested implant material. At the same time, factors that need to be considered include techniques for constructing the particular defect model, the scaffold/graft material used, the availability of animal model evaluation techniques and instrumentation, as well as costs and time constraints. In this article, we summarize the common oral hard tissue defect models in various animal species (such as periodontal model, jaw defect model, and implantation defect model) that can be used to evaluate the regenerative efficacy and biocompatibility of implant materials.

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A comparative study of the effects of platelet-rich fibrin, concentrated growth factor and platelet-poor plasma on the healing of tooth extraction sockets in rabbits

Cited by 11 publications

References 45 publications

Artesunate-loaded thermosensitive chitosan hydrogel promotes osteogenesis of maxillary tooth extraction through regulating T lymphocytes in type 2 diabetic rats

Artesunate-loaded thermosensitive chitosan hydrogel promotes osteogenesis of maxillary tooth extraction through regulating T lymphocytes in type 2 diabetic rats

Efficacy of concentrated growth factors for tympanic membrane perforation: a study in guinea pigs

Oral hard tissue defect models for evaluating the regenerative efficacy of implant materials

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