A comparative study of the antioxidant and ACE inhibitory activities of selected herbal extracts

Chaudhary, Neha; Sabikhi, Latha; Hussain, Shaik Abdul; H, Sathish Kumar M

doi:10.1016/j.hermed.2020.100343

Cited by 14 publications

(14 citation statements)

References 33 publications

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Section: Resultssupporting

confidence: 92%

“…This activity is directly related to the phenolic compound content, so that the higher the amount of these bioactive compounds, the higher the ACE inhibitory activity. This fact has been confirmed in this study and in others such as the one presented by Chaudhary et al [41] on several medicinal plants. Table 3 shows statistical analysis of the variables studied (plants, extraction method and concentration) and the antimicrobial effect on the six pathogenic bacteria analysed, as well as their interactions (p < 0.05).…”

Section: Resultssupporting

confidence: 92%

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Antioxidant, Antihypertensive and Antimicrobial Properties of Phenolic Compounds Obtained from Native Plants by Different Extraction Methods

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Casquete

Martínez

et al. 2021

IJERPH

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This study aims to evaluate the efficacy of two methods (agitation and ultra-sound) for extracting phenolic compounds from 15 native plants. Plant species collected in the Dehesa of Extremadura were used. The antioxidant, antihypertensive and antimicrobial activity of the phenolic extracts was investigated. Significantly different results were obtained when comparing the two extraction methods, with the highest concentrations of phenolic compounds found for ultrasound extraction. In addition, the extracts obtained for Cistus albidus, Cistus salviifolius, Rubus ulmifolius and Quercus ilex showed the highest concentrations of phenolic compounds. The antioxidant activity was higher in the extracts of Cistus and Q. ilex obtained by ultrasound, as was the antihypertensive activity. Antimicrobial activity was also higher in the extracts obtained by ultrasound from C. salviifolius and Q. ilex plants against bacteria and from Cistus ladanifer against yeasts. Therefore, it can be concluded that, with the ultrasound extraction of phenolic compounds from C. ladanifer, C. albidus and Q. ilex plants, it is possible to obtain extracts with important functional properties, so they could be studied for their use in food with the aim of obtaining healthy and safe products, favouring the sustainability of the environment of the Dehesa Extremeña.

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Section: Resultssupporting

confidence: 92%

Section: Resultssupporting

confidence: 92%

Antioxidant, Antihypertensive and Antimicrobial Properties of Phenolic Compounds Obtained from Native Plants by Different Extraction Methods

Boy

Casquete

Martínez

et al. 2021

IJERPH

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“…The lectins (ASA and ASA1) from garlic inhibited both HIV-1 replication and viral attachment in the later stages of infectious virus cycle of SARS-CoV ( Keyaerts et al, 2007 ). Garlic extract inhibited angiotensin converting enzyme (ACE)2, a functional receptor for SARS-CoV Li et al (2003) by 39.57% at a dose of 10 mg/ml Chaudhary et al (2020) indicating its potential antiviral activity against SARS-CoV. A. sativum contains various other bioactive compounds including alliin, allicin, vinyldithis and flavonoids ( Chavanet al, 2016 ; Kim et al, 2018 ; Baek et al, 2019 ; Phan et al, 2019 ; El-Saber Batiha et al, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

African and Asian Medicinal Plants as a Repository for Prospective Antiviral Metabolites Against HIV-1 and SARS CoV-2: A Mini Review

2021

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Introduction: The worldwide burden of viral infections has triggered a resurgence in the search for new and more efficient antiviral drugs. Scientists are also repurposing existing natural compounds such as the antimalarial drug artemisinin from Artemesia annua L. as potential drug candidates for some of the emerging and re-emerging viral infections such as covid-19Aim: The aim of this review was to analyse the existing literature to explore the actual or potential natural antiviral compounds from African and Asian medicinal plants as lead compounds in the drug discovery process.Methods: We searched the literature on African and Asian medicinal plant species as antiviral agents for HIV-1 and the novel coronavirus (SARS-CoV-2) in various databases and search engines such as Web of Science, Google Scholar and PubMed. The search was limited to in vitro, in vivo, and clinical studies and excluded in silico studies.Results: We present 16 plant species with actual or potential antiviral activity against HIV-1 and SARS-CoV-2. These plant species span the continents of Africa and Asia where they are widely used for treating several other ailments.Conclusion: Natural compounds from plants can play a significant role in the clinical management of HIV/AIDS and the covid-19 pandemic. More research needs to be conducted to investigate the potential toxicities of the various compounds and their efficacies in clinical settings.

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“…It is noticeable that polyphenolic compounds were found to potentially contribute to renin inhibition and ACE inhibition; which could be supported by the renin inhibitory activities of tea, 14 saponin from soybean, 15 polyphenolic extracts of two green leafy vegetables vernonia amygdalina, and gongronema latifolium, 16 and by the ACE inhibitory activities of polyphenols from tomato, 17 flavonoids from the buds of Rosa damascene, 18 and polyphenols from Indian gooseberry. 19 All these studies suggested that polyphenolic ingredients are promising as candidates for renin inhibitors and ACE inhibitors.…”

Section: Introductionmentioning

confidence: 99%

Dual inhibition of the renin and angiotensin converting enzyme activities of aqueous extracts of 22 edible flower petals

et al. 2022

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A comparative study of the antioxidant and ACE inhibitory activities of selected herbal extracts

Cited by 14 publications

References 33 publications

Antioxidant, Antihypertensive and Antimicrobial Properties of Phenolic Compounds Obtained from Native Plants by Different Extraction Methods

Antioxidant, Antihypertensive and Antimicrobial Properties of Phenolic Compounds Obtained from Native Plants by Different Extraction Methods

African and Asian Medicinal Plants as a Repository for Prospective Antiviral Metabolites Against HIV-1 and SARS CoV-2: A Mini Review

Dual inhibition of the renin and angiotensin converting enzyme activities of aqueous extracts of 22 edible flower petals

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