A comparative study of the biological activities of arprinocid and arprinocid-1-N-oxide

Wang, Ching C.; Simashkevich, Paula M.

doi:10.1016/0166-6851(80)90051-1

Cited by 18 publications

(5 citation statements)

References 14 publications

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“…Good control of coccidiosis can be achieved by oral administration of either arprinocid or arprinocid-1-iV-oxide. The mode of action of arprinocid has not been determined unequivocally but detailed studies have been carried out by ; Wang, Tolman, Simashkevich & Stotish (1979); Wang, Simashkevich & Fan (1981) and Wang & Simashkevich (1980). In addition to its inhibition of many pyridine nucleotide-requiring enzymes, arprinocid may interfere with the uptake of hypoxanthine and guanine by coccidia.…”

Section: Mode Of Action Of Arprinocidmentioning

confidence: 99%

The interactions between drugs and the parasite surface

Chappell

1988

Parasitology

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SUMMARYThe interrelationships between drugs and parasite surfaces are considered under the headings of (a) effects on membrane transport, (b) drug uptake mechanisms and (c) effects on surface morphology and function: praziquantel is discussed under a separate heading. The range of chemotherapeutic compounds that cause permeability changes and concomitant morphological disruption is discussed in terms of mode of drug action. Interpretation of the available data renders it difficult to identify the primary mode of action in the drugs considered. Drug uptake mechanisms are known for relatively few compounds; drug resistance as a function of drug acquisition is discussed. The role of the parasite surface as a specific drug target is argued.

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Section: Mode Of Action Of Arprinocidmentioning

confidence: 99%

The interactions between drugs and the parasite surface

Chappell

1988

Parasitology

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“…From the in vitro work of Wang et al (1981) we expected that the merozoites would likewise be vacuolated but this was not evident. This could be due to differences between strains of E. tenella and in the concentrations of drug used, but is more likely to be caused by differences between the action of drug in vivo compared to in vitro (Wang & Simashkevich, 1980;Wang et al 1981).…”

Section: Discussionmentioning

confidence: 99%

Morphological effects of arprinocid on developmental stages ofEimeria tenellaandE. brunetti

Ball¹,

Pittilo

Norton

et al. 1985

Parasitology

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Medication of chicks with 70 p.p.m. arprinocid in the food, starting 2 days prior to inoculation with Eimeria tenella, resulted in decreased oocyst production and oocyst sporulation. The main morphological alteration seen during the development of the second-generation schizont was a reduction in the number of second-generation merozoites due to incomplete merogony, resulting in large masses of vacuolated residual cytoplasm. In places around the developing macrogamete the integrity of the parasitophorous vacuole was lost by either the host cell limiting membrane making contact with the parasite pellicle, or the disruption of one or both of these surfaces apparently brought about by the intervention of the host cell mitochondria. Thirty p.p.m. arprinocid reduced sporulation of the oocysts of E. brunetti and caused enlargement of the perinuclear space in the late merozoites and swelling of the endoplasmic reticulum around wall-forming bodies II.

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“…This drug is metabolized in the chicken and excreted primarily as arprinocid-1-N-oxide ( Wang et al 1979a;Wang and Simashkevich 1980). The mode of action of either of these two compounds is unclear, although it has been suggested that their mechanism may involve cytochrome P-450-mediated microsomal metabolism leading to the destruction of the endoplasmic reticulum and to cell death (Wang et al 1979b;Wang et al 1981).…”

Section: Discussionmentioning

confidence: 99%

A Genetic Linkage Map of the Apicomplexan Protozoan Parasite Eimeria tenella

Shirley¹,

Harvey²

2000

Genome Res.

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Apicomplexan protozoan parasites have complex life cycles that involve phases of asexual and sexual reproduction. Some genera have intermediate insect hosts, for example, Plasmodium spp. (the cause of malaria), but related genera such as Eimeria spp. (causative agents of coccidiosis in poultry) have a direct life cycle occurring in only a single host. Mechanisms that regulate the life cycles of apicomplexan parasites are unknown, but the intracellular growth of avian Eimeria spp. is easily shortened by serial selection for the first parasites to complete the transition from asexual to sexual reproduction (to yield so-called precocious lines). To investigate the genetic basis of such an abbreviated life cycle, we have used the species E. tenella and analyzed the inheritance of 443 polymorphic DNA markers in 22 recombinant cloned progeny derived from a cross between parents that had selectable phenotypes of precocious development or resistance to an anticoccidial drug. The markers were placed in 16 linkage groups (which defined 12 chromosomes) and a further 57 unlinked groups. Two linkage groups showed an association (P = .0105) with the traits of precocious development or drug-resistance and were mapped to chromosome 2 (ca 1.2 Mbp) and chromosome 1 (ca 1.0 Mbp), respectively. The map provides a framework for further studies on the identification of genetic loci implicated in the regulation of the life cycle of an important protozoan parasite and a representative of a major taxonomic group.[A table with the segregation data is available as an online supplement at http://www.genome.org.]

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A comparative study of the biological activities of arprinocid and arprinocid-1-N-oxide

Cited by 18 publications

References 14 publications

The interactions between drugs and the parasite surface

The interactions between drugs and the parasite surface

Morphological effects of arprinocid on developmental stages ofEimeria tenellaandE. brunetti

A Genetic Linkage Map of the Apicomplexan Protozoan Parasite Eimeria tenella

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