A comparative study of the effects of mexidolum and mildronatum on the physical performance of experimental animals

Воронина, Т. А.; Kapitsa, I. G.; Ivanova, E. A.

doi:10.17116/jnevro20171174171-74

Cited by 10 publications

(1 citation statement)

References 4 publications

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“…Bromantane, which is widely used in clinical and experimental medical practice for improvement of physical endurance and performance [29], was used as a reference drug; it was administered intragastrically at a dose of 50 mg/kg similar to the compounds under study.…”

Section: The Studied Compoundsmentioning

confidence: 99%

The effect of 3,7-diazabicyclo[3.3.1]nonanescontaining monoterpenoid moieties on the physical activity of mice.

Kotlyarova¹,

Ponomarev²,

Морозова³

et al. 2020

jrp

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The aim of this work is to study the effect of agents combining fragments of monoterpenoids and 3,7diazabicyclo[3.3.1]nonane (bispidine) on the performance of mice. Physical endurance was studied using two tests: exhaustive swimming with a load of 7% of body weight (after single dosing) and exhaustive treadmill running (after single dosing and a 7-day administration). It has been shown for the first time that derivatives of monoterpenoids with 3,7-diazabicyclo[3.3.1]nonane moiety containing methyl substituents at positions 1 and 5 have a stimulatory effect on the performance of mice, which exceeds the effect of the reference drug bromantane after single dosing. Compound K1-458, which contains (-)-myrtenal residues linked to a bispidine fragment via amino groups, is the most effective in increasing the duration of running and swimming at a dose of 100 mg/kg after single intragastric administration. It has been also established that the LD50 for these compounds exceeds 1,000 mg/kg.

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Section: The Studied Compoundsmentioning

confidence: 99%