A comparative study of the effects of different bioactive fillers in PLGA matrix composites and their suitability as bone substitute materials: A thermo-mechanical and in vitro investigation

Simpson, Rebecca; Nazhat, Showan N.; Blaker, Jonny J.; Bismarck, Alexander; Hill, Robert G.; Boccaccını, Aldo R.; Hansen, Ulrich; Amis, AA

doi:10.1016/j.jmbbm.2015.06.008

Cited by 32 publications

(55 citation statements)

References 31 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, upregulation of alkaline phosphatase (ALP) expression was observed in n-HA containing composite resulting in heterotopic bone formation [47]. Similarly using PLGA, Simpson et al systematically evaluated the upregulation of rheological, thermal, and mechanical properties by reinforcing with CaCO 3 , HA, and two bioglass systems prepared by an extrusion process [48]. These results suggest the utility of extrusion as a technique to fabricate dense solid composites that could eventually replace currently used medical device biomaterials.…”

Section: Processingmentioning

confidence: 99%

Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering

Narayanan

Vernekar

Kuyinu

et al. 2016

Advanced Drug Delivery Reviews

380

240

View full text Add to dashboard Cite

Regenerative engineering converges tissue engineering, advanced materials science, stem cell science, and developmental biology to regenerate complex tissues such as whole limbs. Regenerative engineering scaffolds provide mechanical support and nanoscale control over architecture, topography, and biochemical cues to influence cellular outcome. In this regard, poly (lactic acid) (PLA)-based biomaterials may be considered as a gold standard for many orthopaedic regenerative engineering applications because of their versatility in fabrication, biodegradability, and compatibility with biomolecules and cells. Here we discuss recent developments in PLA-based biomaterials with respect to processability and current applications in the clinical and research settings for bone, ligament, meniscus, and cartilage regeneration.

show abstract

Section: Processingmentioning

confidence: 99%

Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering

Narayanan

Vernekar

Kuyinu

et al. 2016

Advanced Drug Delivery Reviews

380

240

View full text Add to dashboard Cite

show abstract

“…Different printing technologies were used to develop 3D scaffolds for bone tissue engineering applications (Table ). Fused Deposition Modeling was the most frequently used printing technology as it was employed in 38 studies (Figure ) . Low‐temperature deposition manufacturing was used in 11 studies, selective laser sintering in seven studies, Stereolitography in three studies …”

Section: Resultsmentioning

confidence: 99%

“…PCL was the most used polymer as it was found in 29 articles . PLA was used in 13 studies and PLGA in 14 studies . Polyethylene glycol (PEG) was also used in six studies but not as major polymer: it was mixed with PLA, PCL, or with polyoxyethylene terephthalate and polybutylene terephthalate (PEOT/PBT) .…”

Section: Resultsmentioning

confidence: 99%

“…TCP was the most frequent and it was used in 32 studies . HA was the second most used mineral, in its non‐modified form in 25 studies, its carbonated form in two studies, its sintered form in one study or just as an apatite coating in two studies . In two cases, HA and TCP were mixed together to obtain biphasic calcium phosphate (BCP) .…”

Section: Resultsmentioning

confidence: 99%

“…The literature showed that one of the limits associated with bioceramics, like HA and TCP, is their fragility . Previous studies have shown that polymer association with a mineral charge could lead to higher mechanical resistance by improving resistance to compression and elasticity . The addition of calcium phosphate (CaP) has also an impact on material roughness.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

3D printed polymer–mineral composite biomaterials for bone tissue engineering: Fabrication and characterization

et al. 2019

View full text Add to dashboard Cite

Applications in additive manufacturing technologies for bone tissue engineering applications requires the development of new biomaterials formulations. Different three‐dimensional (3D) printing technologies can be used and polymers are commonly employed to fabricate 3D printed bone scaffolds. However, these materials used alone do not possess an effective osteopromotive potential for bone regeneration. A growing number of studies report the combination of polymers with minerals in order to improve their bioactivity. This review exposes the state‐of‐the‐art of existing 3D printed composite biomaterials combining polymers and minerals for bone tissue engineering. Characterization techniques to assess scaffold properties are also discussed. Several parameters must be considered to fabricate a 3D printed material for bone repair (3D printing method, type of polymer/mineral combination and ratio) because all of them affect final properties of the material. Each polymer and mineral has its own advantages and drawbacks and numerous composites are described in the literature. Each component of these composite materials brings specific properties and their combination can improve the biological integration of the 3D printed scaffold. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B:2579–2595, 2019.

show abstract

Thermal and mechanical properties of UHMWPE/HDPE/PCL and bioglass filler: Effect of polycaprolactone

Espinosa

Escobar-Barrios

Escobedo

et al. 2020

J of Applied Polymer Sci

View full text Add to dashboard Cite

Polymeric composites based on polyethylene, high‐density polyethylene (HDPE) and ultra‐high‐molecular‐weight polyethylene (UHMWPE) with polycaprolactone (PCL) and a ceramic filler (bioglass type) were studied in terms of their thermal and mechanical behavior. Two polyethylene ratios (10/90 and 30/70% wt/wt of UHMWPE/HDPE) and two PCL content ratios (5% and 10% wt/wt) were used. The obtained composites were characterized by differential scanning calorimetry, melt flow index, Fourier transform infrared spectroscopy, scanning electron microscopy, and X‐ray diffraction. The results indicate a nonchemical interaction between polyethylene, especially the UHMWPE, and PCL and that the composites' thermal transitions vary from the parent polymers and depend on the PCL concentration. The PCL's melting temperature in the composite was reduced, showing a new one. Also, the melting enthalpy of polyethylene was reduced when the concentration of PCL increased. The mechanical behavior depends on both the polyethylene ratio and the PCL content. The composite with 30% wt/wt of UHMWPE and 10% wt/wt of PCL showed the highest toughness value due to the good interaction between polymers. These new composites may be attractive for biomedical applications and could be evaluated, for example, as materials for prostheses.

show abstract

A comparative study of the effects of different bioactive fillers in PLGA matrix composites and their suitability as bone substitute materials: A thermo-mechanical and in vitro investigation

Cited by 32 publications

References 31 publications

Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering

Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering

3D printed polymer–mineral composite biomaterials for bone tissue engineering: Fabrication and characterization

Thermal and mechanical properties of UHMWPE/HDPE/PCL and bioglass filler: Effect of polycaprolactone

Contact Info

Product

Resources

About