A comparative study of serum effusion albumin gradient and Light's criteria to differentiate exudative and transudative pleural effusion

Sandeesha, V; Kiran, Ch Veerendra Ravi; Ushakiran, P; Sulemani, D; Lakshmanakumar, N

doi:10.4103/jfmpc.jfmpc_321_20

Cited by 8 publications

(12 citation statements)

References 21 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study show analysis of biochemical parameters (LDH, pH, Glucose, Triglycerides, Cholesterol, Creatinine, Amylase and ADA) in both pleural fluid and serum. Results of present study were consistent with the other study conducted by Sandeesha V et al (2020), 5 Das AK et al (2009), 6 Burgess LJ et al (1995), 7 Dhar MC et al (2000). 8 According to present study Lights criteria's specificity for exudate was 96.43% and sensitivity was 100%.…”

Section: Discussionsupporting

confidence: 92%

Diagnostic role of different biochemical parameters in pleural effusion

Singh

Singh²,

Saini³

et al. 2022

IJCBR

View full text Add to dashboard Cite

A pleural effusion, an excessive accumulation of fluid in the pleural space, indicates an imbalance between pleural fluid formation and removal. For diagnosing and treatment plan, pleural effusions have to be classified into transudate and exudate. The aim of present study was to analyze various biochemical parameters (LDH, pH, Glucose, Triglycerides, Cholesterol, Creatinine, Amylase and ADA) in pleural fluid and to correlate these Biochemical parameters with diagnosis of the patients. The study was a hospital based descriptive study. The study was conducted over a period of one year on 100 samples. Total 100 samples were enrolled in the study. Both serum and pleural fluid samples were collected and quantitatively analyzed using semi-automated analyzer. The results of the present study shows thatThe Mean±SD of concentration of glucose in pleural fluid was 65.69±14.13 mg/dl, total protein 3.53±1.53g/dl, albumin 1.64±0.85g/dl, cholesterol 58.9±13.05mg/dl, triglycerides 68.7±10.47mg/dl, creatinine 1.73±0.96mg/dl, amylase 49.56±17.78IU/L, LDH 299.82±65.46 U/L and ADA was 49.56±17.78U/L.It was concluded that Biochemical parameters play important role in diagnosing Pleural effusions. These markers when used collectively their diagnostic efficacy is greatly increased. The SEAG is superior to Light's criteria in identifying the transudative effusions. It is also observed that Light's criteria identified exudative effusions better than SEAG.

show abstract

Section: Discussionsupporting

confidence: 92%

Diagnostic role of different biochemical parameters in pleural effusion

Singh

Singh²,

Saini³

et al. 2022

IJCBR

View full text Add to dashboard Cite

show abstract

“…All patients with heart failure who had been misclassified as having exudates based on Light’s criteria were correctly classified using the albumin gradient calculation. Sandeesha et al 27 reported results with a similar study based on 66 patients. Twenty of 22 patients with transudates and 41 of 44 patients with exudates were correctly classified using this gradient.…”

Section: Pleural Effusion Analysis Using Nt-pro-bnp and Serum To Flui...mentioning

confidence: 80%

Pleural Effusions in Patients With Congestive Heart Failure: Frequency, Pathogenesis, Diagnosis, and Implications

Elgwairi

Abdalla

Elkheshen

et al. 2022

Cardiology in Review

View full text Add to dashboard Cite

Patients with cardiac disease frequently develop pleural effusions; the incidence is approximately 500,000 cases per year in the United States. These effusions often represent important clinical events for patients, indicating that either there has been an acute change in the patient's clinical status or the patient's chronic management program needs review. These effusions usually develop in both the right and left hemithorax but can be unilateral. The pathogenesis involves increased fluid transfer from parietal pleural capillaries into the pleural space and possibly decreased pleural fluid uptake into parietal pleural lymphatic structures. The increased fluid transfer develops due to increased capillary pressure secondary to elevated venous outflow pressure and secondary to decreased lymphatic flow into central vessels secondary to heart failure. Most pleural effusions associated with heart failure are transudates, but 20% to 25% have increased protein and lactate dehydrogenase levels suggesting an exudative process. Additional testing can clarify the situation and requires calculation of the serum albumin to pleural fluid albumin gradient or measurement of N-terminal pro-brain natriuretic peptide in the pleural fluid. An albumin gradient of greater than 1.2 g/dL suggests that the fluid is a transudate. The presence of a pleural effusion in a hospitalized patient at discharge is associated with an increased likelihood of rehospitalization and mortality within the next year. Patients with large symptomatic pleural effusions may require therapeutic thoracentesis. Recurrence of symptomatic effusions presents a management dilemma that might require repeated thoracenteses, indwelling intrapleural catheter placement, or other management steps used in advanced chronic heart failure.

show abstract

“…Exudative pleural effusion diagnosed first by using Light's criteria, suggesting that pleural effusion is an exudate if effusion protein/serum protein ratio greater than 0.5 and, effusion lactate dehydrogenase (LDH)/serum LDH ratio greater than 0.6, or pleural fluid LDH concentration is less than 2/3 of the upper reference limit. 1…”

Section: Inclusion Criteriamentioning

confidence: 99%

“…But results may be false positive may occur in patients with transudative effusions when (Light's criteria) were applied. 1 The cholesterol level of pleural fluid can be used as a variable in diagnosing effusion of exudative natur eand even can replace (Light's criteria). Approaches to diagnos epleural effusion patients must be precise as multiple procedures depend on nature and analysis of the effusion fluid.…”

Section: Introductionmentioning

confidence: 99%

Accurate and Rapid Diagnosis of Exudative Pleural Effusion.

Ghatas

Elfaizy

2021

Al-Azhar International Medical Journal

View full text Add to dashboard Cite

Background: Accurate diagnosis of exudate pleural effusion is definitely important. Few studies have been published on this topic. The current work present evidence for the importance of the pleural fluid markers like high sensitivity-C reactive protein [hsCRP]; tumor necrosis factor alpha [TNFα]; and cholesterol levels measurement in differentiating types of exudative from transudative pleural effusion. Aim of The Work: to determine and evaluate the diagnostic importance of measured levels of pleural fluid cholesterol, high sensitivity-CRP and tumor necrosis factor α in diagnosing and differentiating transudate from exudate pleural effusion. Patient and Methods: This study was carried out on 100 patients suffering from pleural effusion who subjected to diagnostic evaluation at Al Sahel Teaching Hospital. The full biochemical analysis of the pleural fluid,pleural fluid culture, and cytology examination were also performed. TN Fα ,hsCRP, and cholesterol level were assessed in the samples of pleural fluid. Results: One hundred patients were initially evaluated, in accordance to Light's criteria, of 100 patients suffering from pleural effusion, 67 had exudative effusions while 33 patients had transudative pleural effusion. The concentrations of pleural fluid hsCRP and TNF α, found to be significantly elevated in the exudative nature group of pleural fluid than the transudative pleural effusion group (p < 0.05). Also, pleural fluid cholesterol level was elevated in the exudative pleural effusion than transudative pleural effusion(P<0.001). Conclusion:Patients presented with pleural effusion, simple markers of elevated pleural fluid hsCRP, TNFα, and cholesterol levels may be helpful in discrimination between exudates and transudates effusion.

show abstract

A comparative study of serum effusion albumin gradient and Light's criteria to differentiate exudative and transudative pleural effusion

Cited by 8 publications

References 21 publications

Diagnostic role of different biochemical parameters in pleural effusion

Diagnostic role of different biochemical parameters in pleural effusion

Pleural Effusions in Patients With Congestive Heart Failure: Frequency, Pathogenesis, Diagnosis, and Implications

Accurate and Rapid Diagnosis of Exudative Pleural Effusion.

Contact Info

Product

Resources

About