A comparative study of seminal trace elements in fertile and infertile men

Umeyama, Tomokazu; Ishikawa, Hiromichi; Takeshima, Hitoshi; Yoshii, Shinichi; Koiso, Kenkichi

doi:10.1016/s0015-0282(16)49593-2

Cited by 85 publications

(61 citation statements)

References 12 publications

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“…Calcium also binds to the sperm surface which can lead to differences between measurements on whole semen versus seminal plasma [20]. While some studies observed no significant difference in seminal total calcium concentrations in fertile and infertile men and also in men exhibiting seminal hypo-motility and normal motility [14,21], others studies demonstrated a relationship between high calcium levels and fertility in men [22].…”

Section: Discussionmentioning

confidence: 99%

Seminal Plasma pH, Inorganic Phosphate, Total and Ionized Calcium Concentrations In The Assessment of Human Spermatozoa Function

Banjoko

Adeseolu

2013

JCDR

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Introduction: Fertilization in humans is dependent on viability of the male spermatozoa among other factors and there have been conflicting reports on the role of pH, calcium and phosphate concentrations in sperm function. This study therefore aimed to investigate seminal plasma pH, inorganic phosphate, total and ionized calcium concentrations relative to spermatozoa function. Material and Methods: Seminal plasma concentrations of pH, total calcium, ionized calcium (Ca ++ ); inorganic phosphate, motility and spermatozoa count were determined in 80 males by standard methods.Results: Forty-nine of the subjects had normal spermatozoa motility (> 60%) and 31 had hypomotility (< 60%). The hypomotility group exhibited lower calcium ion (Ca 2 +) concentrations; 0.19+0.01mmol/L compared with normal motility group; 0.24+0.01mmol/L (p<0.001) the latter also had significantly higher inorganic phosphate; 7.83+1.27 while the former had 5.64+1.62mmol/L (p= 0.004). The mean spermatozoa counts for hypomotility and normal motility group were 42.0 ± 13 x 106 , 72.35 + 20 x 106 respectively (p< 0.001). No significant differences were observed in pH, volume of ejaculate and total calcium concentration between the hypomotility and normal motility groups The mean concentrations of pH were 7.51 ± 0.02 and 7.54 ± 0.03 respectively (p= 0.21) and total calcium; 3.10 ± 0.12 and 3.36 ± 0.14mmol/L respectively (p= 0.16 ). There was a significant difference in percentage of abnormal forms in both groups with hypomotile group having 36% compared to mormal motility group with 5% (p< 0.05). Conclusion:Correlations were observed between seminal concentrations of calcium ions, inorganic phosphate, spermatozoa count and motility but not with total calcium concentrations and pH and therefore should be considered in understanding male infertility and preparation of media for sperm preservation for in vitro fertilization.

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Section: Discussionmentioning

confidence: 99%

Seminal Plasma pH, Inorganic Phosphate, Total and Ionized Calcium Concentrations In The Assessment of Human Spermatozoa Function

Banjoko

Adeseolu

2013

JCDR

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“…In a study of environmental chromium exposure, seminal chromium levels were not signifi cantly different between fertile and infertile men (127). However, blood chromium was significantly associated with an increase in serum prolactin (107), and a non-linear decrease in serum inhibin B (119) after adjusting for age, BMI, and smoking status, or other metals in both studies.…”

Section: Effects Of Environmental Exposure To Metals On Reproductive mentioning

confidence: 95%

Reproductive Toxicity of Metals in Men

Pizent¹,

Tariba²,

Živković³

2012

Archives of Industrial Hygiene and Toxicology

106

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A combination of genetic, environmental and lifestyle factors contributes to adverse effects on the reproductive health in men. Metals are pervasive in food, water, air, tobacco smoke, and alcoholic beverages. Experimental studies suggest that many metals have adverse effects on the male reproductive function. However, information about reproductive effects of human exposure to metals is scarce and/or inconsistent. This review summarises the information from epidemiological studies of the effects of metal exposure on reproductive function in men. Factors capable of affecting these relationships were identifi ed and discussed. A particular attention is given to the studies considering infl uence of concomitant exposure to various metals. These studies have generally confi rmed that even moderate-to low-level exposure to lead affects certain reproductive parameters, and that exposure to cadmium affects the prostate function and serum testosterone levels. Adverse effects of mercury, manganese, chromium and arsenic on semen quality and altered serum hormone are less well documented. There is no clear evidence that boron exposure may impair reproductive health in men. Only a few studies have investigated reproductive effects of concomitant exposure to several metals and controlled for potential confounders. Future studies should consider the contribution of combined exposure to various metals and/or other factors that may infl uence individual susceptibility to reproductive health impairment in men. KEY WORDS: human semen quality, metals, metalloids, metal interactions, sex hormonesPizent A, et al.

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“…Exposure to metals (mainly lead and cadmium) has been long associated with low sperm motility and density, increased morphological anomalies and male infertility [24,62]. Males employed in metal industries had a decreased fertility when compared with other workers as shown by a delayed pregnancy and reduced semen quality [26,36,45,[63][64][65][66][67][68][69].…”

Section: Metalsmentioning

confidence: 99%

Occupational and Lifestyle Exposures on Male Infertility: A Mini Review

Ten¹,

Mendiola²,

Torres-Cantero³

et al. 2008

TORSJ

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Human semen quality may be declining due to environmental pollutants, occupational exposures or changes in lifestyle. Nonetheless, we still know little about the impact of those factors on male fertility. Some heavy metals, volatile organic compounds or xenoestrogens may compromise reproductive male function. This process could take place along the human life cycle and not only in certain stages of development. We review the main factors that affect human male fertility and their possible influence in current human reproduction.

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A comparative study of seminal trace elements in fertile and infertile men

Cited by 85 publications

References 12 publications

Seminal Plasma pH, Inorganic Phosphate, Total and Ionized Calcium Concentrations In The Assessment of Human Spermatozoa Function

Seminal Plasma pH, Inorganic Phosphate, Total and Ionized Calcium Concentrations In The Assessment of Human Spermatozoa Function

Reproductive Toxicity of Metals in Men

Occupational and Lifestyle Exposures on Male Infertility: A Mini Review

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