A comparative study of psoriasis and psoriasiform lesion on basis of CD4 and CD8 cell infiltration

Rana, Safia; Zeeba, Jairajpuri S; Sujata, Jetley; Kudesia, Madhur

doi:10.7241/ourd.20124.64

Cited by 5 publications

(3 citation statements)

References 21 publications

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“…The count of inflammatory cells infiltration in our study were concordant with Rana et al (10) who observed that the difference in percentage of cells was statistically significant (p=0.002), on comparing the infiltration of inflammatory cells between psoriasis and psoriasiform lesions.…”

Section: Discussionsupporting

confidence: 92%

A Comparative Study of Psoriasis and Psoriasiform Dermatoses on Basis of Ki-67 Immunohistochemical Expression

Abdelsalam¹,

Gobran²,

Abdelwahab³

et al. 2022

The Egyptian Journal of Hospital Medicine

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Section: Discussionsupporting

confidence: 92%

A Comparative Study of Psoriasis and Psoriasiform Dermatoses on Basis of Ki-67 Immunohistochemical Expression

Abdelsalam¹,

Gobran²,

Abdelwahab³

et al. 2022

The Egyptian Journal of Hospital Medicine

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“…Keratinocyte hyper proliferation with parakeratosis and elongation or rete ridges, increased blood vessels synthesis, inflammatory cells infiltration like T lymphocytes, macrophages, neutrophils, dendritic cells, and presence of micro abscesses are the major histological features of psoriasis. Among different types of psoriasis like pustular psoriasis, inverse psoriasis, psoriatic arthritis guttate psoriasis and erythrodermic psoriasis, psoriasis vulgaris or chronic plaque psoriasis is the most common form of psoriasis (Mahajan & Handa, ; Rana, Zeeba, Sujata, & Madhur, ). Diet plays important role in psoriasis pathogenesis and etiology.…”

Section: Introductionmentioning

confidence: 99%

“…Among different types of psoriasis like pustular psoriasis, inverse psoriasis, psoriatic arthritis guttate psoriasis and erythrodermic psoriasis, psoriasis vulgaris or chronic plaque psoriasis is the most common form of psoriasis (Mahajan & Handa, 2013;Rana, Zeeba, Sujata, & Madhur, 2012). Diet plays important role in psoriasis pathogenesis and etiology.…”

mentioning

confidence: 99%

Progress and prospects in the management of psoriasis and developments in phyto‐therapeutic modalities

Daniyal

Akram

Zainab

et al. 2019

Dermatologic Therapy

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The aim of this study is to review the efficacy of herbal and allopathic drugs used to manage and treat psoriasis. The review has been compiled using reference materials from major databases, Online Journals, Science Direct, Scopus, Open J Gate, Google Scholar and PubMed. Psoriasis is a common skin disease affecting 2–3% of the world's population. It is cosmetically debilitating and chronic disease, which occurs both in developing and developed countries. It can affect any part of the body, but the most common sites are the elbows, knees, and scalp. It is usually treated with synthetic medicine either given systematically or applied locally. The prescribed synthetic medicines used for the treatment of psoriasis are associated with severe side effects and complications, thus researchers around the world are trying to explore new, more effective, and safer drugs from natural resources. Medicinal plants are safe and efficacious, and most of the people all over the world rely on herbal medicine due to their easy availability, low cost, and efficacy for treating psoriasis. A number of medicinal plants having therapeutic potential with high efficacy are used in the treatment of psoriasis have been described. Moreover, studies should be conducted to isolate and investigate the mechanism of actions of phytochemicals responsible for anti‐psoriasis potential.

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Immunohistochemical expression of P53, Ki-67, and CD34 in psoriasis and psoriasiform dermatitis

Ramezani¹,

Shamshiri²,

Zavattaro³

et al. 2019

BioMedicine

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Background: Psoriasis is the prime example of psoriasiform tissue pattern and should be differentiated from other psoriasiform dermatoses both clinically and histopathologically.Aim: To evaluate immunohistochemical expression of P53, Ki-67, and CD34 in psoriasis and psoriasiform dermatitis for diagnostic purposes.Methods: An analytical cross-sectional study was performed on the paraffin blocks of 60 psoriasis and 31 psoriasiform dermatitis patients between 2014 and 2017. The selected formalin-fixed paraffin-embedded tissues from each biopsy specimen were cut into 4-micron sections. Initial sections were stained by hematoxylin and eosin staining. Primary antihuman antibodies against P53, Ki-67, and CD34 were applied. Positive control samples for biomarkers were received from former strongly positive samples of papillary endothelial hyperplasia, high grade lymphoma, and breast ductal carcinoma for CD34, Ki-67, and P53, respectively.Results: Out of 60 psoriasis patients, 56.7% were men, with the mean age of 36.8 years. From 31 psoriasiform patients, 45.2% were men, with the mean age of 37.5 years. Both groups were matched in terms of sex and age. The mean staining of three markers was more significant in psoriasiform dermatitis than psoriasis.Conclusion: In spite of some other researches, the present study showed expression of P53, Ki-67, and CD34 biomarkers were significantly higher in psoriasiform dermatitis than psoriasis.

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A comparative study of psoriasis and psoriasiform lesion on basis of CD4 and CD8 cell infiltration

Cited by 5 publications

References 21 publications

A Comparative Study of Psoriasis and Psoriasiform Dermatoses on Basis of Ki-67 Immunohistochemical Expression

A Comparative Study of Psoriasis and Psoriasiform Dermatoses on Basis of Ki-67 Immunohistochemical Expression

Progress and prospects in the management of psoriasis and developments in phyto‐therapeutic modalities

Immunohistochemical expression of P53, Ki-67, and CD34 in psoriasis and psoriasiform dermatitis

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