A Comparative Study of Leptin, Oxidant/Antioxidant Status and Some Trace Elements in Women of Healthy Control and Unexplained Infertility in Basrah-Iraq

Al–Fartosy, Adnan J. M.; Awad, Nadhum A.N.; Mahmood, Rsha Abdulradha

doi:10.18585/inabj.v11i3.915

Cited by 8 publications

(12 citation statements)

References 21 publications

(28 reference statements)

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“…Selenium, a trace element, is a major component in glutathione peroxidase (GPx) which is one of the main antioxidant enzymes in the human body and responsible for preventing the production of free radicals, decreasing their activity or destroying them (19). Selenium levels were found significantly lower in T2DM patients with and without DN when compared to healthy control group.…”

Section: Discussionmentioning

confidence: 99%

“…Kidney tubular flaw in handling Zinc and glucose-induced, osmotic diuresis are other probabilities. Furthermore, Zinc may enhance glycaemia and a restored Zinc status in patients with T2DM (with or without DN) may oppose the harmful effects of oxidative stress which helping to prevent complication beneficial antioxidant effects in people with T2DM (19). Zinc has been illustrated to have particularly importance in the light of the mischievous outcomes of oxidative stress in subjects with DM.…”

Section: Discussionmentioning

confidence: 99%

“…Serum Zn and Mg were determined by using GBC 933 Plus flame atomic absorption spectrometry "FAAS" (GBC, Braeside, Australia) (19).…”

Section: Blood Trace Elements Estimationmentioning

confidence: 99%

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Clinical markers and some trace elements in patients with type-2 diabetic nephropathy : Impact of insulin resistance

2021

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INTRODUCTION : Diabetic Nephropathy (DN) is the leading reason of all excess death-rate over type-2 diabetes mellitus (T2DM) patients with microalbuminuria, macroalbuminuria or end-stage renal disease. This work was aimed to estimate insulin resistance (IR) effect on some markers and trace elements (Selenium, Zinc, Magnesium) levels for early predicting of DN in T2DM patients. METHODS : We conducted a cross-sectional clinical study. Blood and urine samples were collected from 63 subjects with T2DM and 33 healthy controls to assess glucose, insulin, IR, urea, creatinine, glomerular filtration rate (GFR), creatinine clearance (CrCl), homocysteine (Hcy), fructosamine (FA), cystatin C (CysC), albumin (Alb), neutrophil gelatinase-associated lipocalin (NGAL), 8-hydroxy-2`-deoxyguanosine (8-OHdG) and trace elements levels. Data were collected using a questionnaire that was filled out by specialized doctors. RESULTS : Compared with controls, the results revealed that T2DM patients with or without DN had significant increases in glucose, insulin, IR, urea, creatinine, Hcy, FA, CysC, Alb, NGAL and 8-OHdG and significant decreases in GFR, CrCl and trace elements levels. Body mass index (BMI) had no changes. CONCLUSION : Uncontrolled T2DM was associated with BMI, IR and physical activity in which elevated Hcy, FA, CysC, Alb, NGAL and 8-OHdG levels and decreased trace elements levels may be used as early clinical markers of DN.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clinical markers and some trace elements in patients with type-2 diabetic nephropathy : Impact of insulin resistance

2021

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“…Results were analysed using the statistical package for the social sciences (SPSS) software (Version 21) and the values were expressed as mean ± standard deviation (SD). The values of p > 0.05 was considered statistically not significant, p < 0.05 was considered as significant differences and p < 0.01 for highly significant in comparison with the corresponding control value (Al-Fartosy et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Insulin resistance and specific biomarkers in blood and urine of type 2 diabetic patients with or without nephropathy in Basrah, Iraq

Al–Fartosy¹,

Awad²,

Alsalimi³

2020

Afr. J. Biochem. Res.

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Diabetic nephropathy (DN) is a master cause of all surplus death-rate among type 2 diabetes mellitus (T2DM) patients with microalbuminuria. This study aimed to find effective biomarkers for early predicting of DN. Present study included 63 patients with T2DM (31 patients with DN, 32 patients without DN) and 33 healthy controls. These three groups were matched for their glucose, urea, creatinine, insulin, L-Carnitine (LC), osteoprotegerin (OPG), sialic acid (SA), trace elements (Selenium, Zinc, Magnesium), albumin (Alb), and fibronectin (FN). Glucose, urea, and creatinine were determined by spectrophotometer. Insulin, LC, OPG, SA, Alb, and FN were assayed by enzyme-linked immunosorbent assay (ELISA). Insulin resistance (IR) was calculated by the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) equation. Selenium was measured by hydride generation while Zinc and Magnesium were measured by flame atomic absorption spectrometer. Compared with controls, the results indicated that T2DM patients with or without DN had a significant increase in glucose, urea, creatinine, insulin, IR, OPG, SA, Alb, FN and a significant decrease in LC and trace elements levels. It was concluded that IR is strongly associated with obesity and had an important role in the pathogenesis and increased complication of diabetes which could be used as excellent indicators for early-stage DN in T2DM patients and thus decreasing mortality and morbidity.

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“…It may be role to stimulating increased IR by down-regulation of insulin receptors and/or due to defects of post receptors. There are several factors involve in the neuroendocrine control of PRL secretion from the anterior pi-tuitary gland which including PRL releasing factors and PRLrelease inhibiting factors, may be exert a tonic inhibitory control [25]. The main physiological PRL release inhibiting factors is dopamine which secreted from the dopaminergic neurons of hypothalamus.…”

Section: Al-fartosy Ajm Et Almentioning

confidence: 99%

Intelectin-1 and Endocrinological Parameters in Women with Polycystic Ovary Syndrome: Effect of Insulin Resistance

2020

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Objectives:We aimed to evaluate the effect of insulin resistance (IR) on serum In telectin1 and endocrinological hormones levels in obese and nonobese women with and without polycystic ovary syndrome (PCOS) in Basrah, Iraq. Methods: From 124 women volunteers, 60 patients with primary and 64 patients with secondary, while 56 normal ovulatory women were taken as controls. Their fasting in sulin hormone, intelectin1, antiMullerian hormone, luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), estradiol (E2) and testosterones (T) were determined by ELISA methods. BMI, glucose and quantitative insulin sensitivity check index as well as IR was determined by the homeostasis model assessment. Results: A significant changes (P<0.05) were seen in the level of homeostasis model assessmentIR, E2 and T. Levels of antiMullerian hormone, LH, LH/FSH ratio and pro lactin were significantly (P<0.01) increased and level of intelectin1 and E2/T ratio were significantly (P<0.01) decreased, while quantitative insulin sensitivity check index level was not significantly different (P>0.05) between the patients (1 o PCOS and 2 o PCOS) and control groups. On the other hand, our data reported that FSH level was significantly (P<0.05) lower in obese and higher in nonobese patients with PCOS as compared to control group. Conclusion: Levels of intelectin1 and endocrinological hormones have significantly associated with body mass index, IR and physical activity in patients and normal groups and the strategies that can modulate levels of these parameters would improve metabolic disarrangements in women with PCOS.

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A Comparative Study of Leptin, Oxidant/Antioxidant Status and Some Trace Elements in Women of Healthy Control and Unexplained Infertility in Basrah-Iraq

Cited by 8 publications

References 21 publications

Clinical markers and some trace elements in patients with type-2 diabetic nephropathy : Impact of insulin resistance

Clinical markers and some trace elements in patients with type-2 diabetic nephropathy : Impact of insulin resistance

Insulin resistance and specific biomarkers in blood and urine of type 2 diabetic patients with or without nephropathy in Basrah, Iraq

Intelectin-1 and Endocrinological Parameters in Women with Polycystic Ovary Syndrome: Effect of Insulin Resistance

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