A comparative study of HPLC-UV and UPLC-DAD methods for simultaneous estimation of aspirin and cilostazol in the presence of their related impurities in bulk and capsules

Elkady, Ehab F.; Tammam, Marwa Hosny; maaty, Ayman Abo El

doi:10.1080/10826076.2017.1296461

Cited by 4 publications

(1 citation statement)

References 21 publications

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“…Aspirin is widely used in low doses in preventing antiplatelet aggregations in patients at dicey of occlusive vascular events 9 . Many analytical approaches have been announced for the definition of ASP like spectrophotometry 10 , HPLC 11 , RP-HPLC 12 , UPLC 13 , TLC 14 , capillary zone electrophoresis 15 and raman spectroscopy 16 . SIL is chemically 5-[2-Ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl]-1methyl-3-propyl-1,6-dihydro-7H-pyrazolo [4,3d]pyrimidin-7-one dihydrogen 2hydroxypropane-1,2,3-tricarboxylate, which belongs to phosphodiesterase inhibitors PDEs, specific type 5, Figure 1 8 .…”

Section: Introductionmentioning

confidence: 99%

Development of Four Uv-Spectrometric Techniques for Concurrent Estimation of Aspirin and Sildenafil Citrate in Their Binary Mixture and Pharmaceutical Formulations

Sakur

Kayali²

2022

Bulletin of Pharmaceutical Sciences. Assiut

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The combination of aspirin (ASP) and sildenafil citrate (SIL) into single dosage form has been of interest for a considerable period; because it has a synergistic effect for the handling of many diseases. Therefore, UV-spectrometric techniques were desperately required for the concurrent estimation of ASP and SIL in their binary mixture and pharmaceutical formulations. In this paper, four simple, low-cost and precise UV-spectrometric techniques were evolved for the concurrent estimation of ASP and SIL. The advanced methods include treatment of the zeroorder spectrum by ratio subtraction (RS) along with spectrum subtraction method (SS), absorption correction method (ACM), area under the curve correction method (AUCCM) and induced dual wavelength method (IDWM). Moreover, UV-spectrometric purity analysis via spectral ratio factor (SRF) was developed; which considered the first UV-spectrometric purity testing to verify the purity of ASP in pharmaceuticals formulations. All approaches were linear; in the range of 25.0-100.0 μg/mL for ASP, and 10.0-50.0 μg/mL for SIL. The mean percentage recoveries for ASP were 100.92, 100.33, 100.79 and 100.18% respectively, and for SIL were 99.27, 99.56, 99.83 and 99.44% respectively. The SRF values were approximating unity and showed high purity of the resolved peaks. The results were statistically compared with the HPLC reported method and no significant variance was discerned.

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