A comparative study of equipotent doses of intrathecal clonidine and dexmedetomidine on characteristics of bupivacaine spinal anesthesia

Background:Clonidine is an alpha-2 adrenergic agonist with various actions, one of which enhances the effectiveness of local anaesthetics. For patients undergoing lower abdominal surgery, we examined the effect of adding intrathecal clonidine to hyperbaric bupivacaine on postoperative pain relief and side effects, if any. Aim:To assess the efficacy of intrathecal clonidine along with hyperbaric Bupivacaine in patients undergoing lower abdominal surgeries.Method: It was a retrospective study carried out under spinal anaesthesia on 80 patients undergoing lower abdominal surgery. The research population was assigned randomly to two groups; group B-received 15 mg bupivacaine+ 0.4mi Normal Saline and group C received 15 mg bupivacaine + 60mcg clonidine.Results: Addition of 60mcgs of intrathecal clonidine to 0.5% hyperbaric bupivacaine significantly prolonged the duration of motor & sensory blockade along with the duration of effective postoperative analgesia. The demand for rescue analgesic was earlier in group B as compared to group C. Both groups were matched for the side-effects like hypotension, bradycardia, nausea, vomiting, and shivering.

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“…This was in line with Rajan et al's analysis where similar results were found as T2SR was 137.00 ± 10.42. 22 in the clonidine group.…”

Section: Discussionmentioning

confidence: 94%

To Determine the Role of Clonidine as an Adjuvant to Intrathecal Bupivacaine in Patients Undergoing Lower Abdominal Surgery

Deshmukh¹,

Parate²,

Chandak³

2020

IJFMT

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“…Also there was a better surgical score (better surgical field) in the clonidine group in a higher number of patients than that of the diazepam group. Few of the studies on Clonidine use in anaesthesia were reported [18][19][20]. Bansal et.…”

Section: Discussionmentioning

confidence: 99%

A Study Protocol for Assessing the Effect of Pre-Emptive Oral Clonidine on Intraoperative Hemodynamics and Surgical Field Quality during Functional Endoscopic Sinus Surgery (FESS) under General Anesthesia

Khandelwal

Sen

2021

JPRI

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Background: Typically, endoscopic sinus surgery is reserved for patients with documented rhinosinusitis. The nasal mucosa is impregnated with supply of highly rich blood vessels, so excessive occurrence of bleeding during the procedure may obscure the visibility of the surgical area which might lead into complications. So to control the intraoperative blood loss, controlled hypotension during the surgery can be adopted. Clonidine, a centrally acting α2 agonist has antihypertensive property with decreasing sympathetic outflow. Clonidine given orally judiciously prior to surgery would potentiate the inhalation agents for hypotensive action during the anaesthetic procedure without having the disadvantages of vasodilators given intravenously. This study to assess the effects of clonidine as an oral premedicant in patients who are undergoing Functional Endoscopic Sinus Surgery. Methodology: This prospective randomized double blinded placebo controlled study will be conducted in the department of Anaesthesia, Acharya Vinoba Bhave Rural Hospital, (DMIMS) Jawaharlal Nehru Medical College Sawangi Wardha, within the period of time of December 2020 to November 2022. Total 60 patients will be enrolled and randomized in two groups: Group C (n= 30): Patients will be given Clonidine (200 μgm); Group P (n= 30) will be Placebo group. To shrink nasal mucosal vessels, all patients will receive nasal packing of 2% xylocaine with 1:200000 adrenaline. Then, 60 minutes after study drugs are given, patients will be shifted for procedure. Using Six-point Average Category Scale, the grading of surgical field in terms of bleeding, will be done by the operating surgeon. Qualitative data will be documented with the help of percentage table, quantitative data will be presented as mean and standard deviation, student t-test will be taken for comparison among the study groups, Chi-square test will be utilized for comparison of categorical data. SPSS (Statistical Package for Social Sciences) 20.0 version will be the Software used in the analysis and p < 0.05 will be considered significant statistically. Expected Results: Oral clonidine when used as premedicant will be effective in reducing bleeding during the procedure of Functional Endoscopic Sinus Surgery.

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“…They concluded that intrathecal low dose analgesia with heavy Bupivacaine + fentanyl + morphine can be used effectively in both primi & multi parturients with no increase in risk of C-section among patients. Few more studies on similar aspects were reviewed [12][13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Intrathecal Dexmedetomidine and Fentanyl as Adjuvant to Bupivacaine for Labour Analgesia: A Study Protocol

Sharma

Chandak

2021

JPRI

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Background: The most commonly used labour analgesia is epidural. Another alternative method is intrathecal low dose analgesic, given for providing labour analgesia in the areas where the epidural kit, multiparameter monitors, staff members scarcity is present. Fentanyl has been used widely to decrease motor block effect of local anaesthetics during labour, presence of these opioids along with local anaesthetics can cause pruritus and respiratory depression. Selective α2- agonist Dexmedetomidine (DMT) helps in providing stable haemodynamic parameters, and an effective intraoperative and postoperative analgesia. This study aims to compare the effectiveness of an intrathecal analgesia during labor, using bupivacaine in combination with dexmedetomidine and fentanyl in terms of quality and duration of analgesia. Materials and Methods: This will be a prospective comparative observational study. Total 80 patients will be included in the study and assigned to two groups by computerized randomization method. GROUP BD (n=40) will receive an intrathecal 0.5% hyperbaric bupivacaine dose 2.5 mg along with dexmedetomidine dose 2.5 μg .GROUP BF (n=40) will receive an intrathecal 0.5% hyperbaric bupivacaine 2.5mg with fentanyl 25mcg. Data will be analysed and Quality and duration of analgesia will be compared for both groups. Expected Results: Significant difference is expected in labor analgesia and safety profile with the combination of intrathecal bupivacaine and dexmedetomidine compared to combination of bupivacaine and fentanyl.

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A comparative study of equipotent doses of intrathecal clonidine and dexmedetomidine on characteristics of bupivacaine spinal anesthesia

Cited by 8 publications

References 0 publications

To Determine the Role of Clonidine as an Adjuvant to Intrathecal Bupivacaine in Patients Undergoing Lower Abdominal Surgery

To Determine the Role of Clonidine as an Adjuvant to Intrathecal Bupivacaine in Patients Undergoing Lower Abdominal Surgery

A Study Protocol for Assessing the Effect of Pre-Emptive Oral Clonidine on Intraoperative Hemodynamics and Surgical Field Quality during Functional Endoscopic Sinus Surgery (FESS) under General Anesthesia

Effectiveness of Intrathecal Dexmedetomidine and Fentanyl as Adjuvant to Bupivacaine for Labour Analgesia: A Study Protocol

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