A Comparative Study of Epidural, Bupivacaine with Buprenorphine and Bupivacaine with Fentanyl in Lower Limb Surgeries

Kumar, Santosh; Ks, Lokesh Kumar; Rajalakshmi, J

doi:10.9790/0853-131232328

Cited by 3 publications

(2 citation statements)

References 2 publications

(1 reference statement)

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“…Its highly lipophilic property allows it to be rapidly absorbed into the spinal venous plexus and thus carries lesser risk of respiratory depression associated with rostral (10) spread of the drug. Santhosh Kumar et al, in a study comparing fentanyl and buprenorphine when given as an adjunct with bupivacaine found no difference in time taken to achieve motor (11) blockade. A similar study by Chakravarthy N N et al, comparing Nalbuphine and Fentanyl found signicantly longer duration of sensory blockade in the Nalbuphine group thus a prolonged duration of (12) analgesia in the Nalbuphine group.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Intrathecal Buprenorphine With Bupivacaine 0.5% and Fentanyl With Bupivacaine 0.5% in Lower Abdominal Surgeries – A Comparative Study

Jobitta

Harshavardhan

2021

ijsr

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Introduction : Spinal anesthesia is one of the commonest and preferred mode of anesthesia for lower abdominal and lower limb surgeries because of its safety and faster post-operative recovery. Bupivacaine is the commonly used anesthetic for intrathecal administration. Drugs such as Fentanyl, Buprenorphine, Clonidine, Dexmeditomedine have been tried as adjuvants to increase the duration of Analgesia and decrease post-operative pain, but addition of these drugs is wrought with side-effects like hypotension and bradycardia. This study aims to compare the efficacy of Fentanyl and Buprenorphine as adjuvants to intrathecal Bupivacaine in lower abdominal surgeries. Methodology : A total of 112 patients undergoing lower abdominal surgeries where administered either the combination of Buprenorphine with Bupivacaine (56 patients, Group B) or Fentanyl with Bupivacaine (56 patients, Group F). Intraoperatively, patients’ vitals HR, NIBP, SpO2, ECG were monitored every 2 minutes once for the first 10 minutes, every 10 minutes once for the next 50 minutes, and 15 minutes once till the end of surgery. Motor and Sensory blockade, duration of Analgesia and Post-operative pain were also recorded. Results : There was no significant difference in the baseline characteristics and intra-operative vitals between the groups. Patients in Group B had a faster Motor and Sensory blockade, longer duration of analgesia and lesser post-operative pain as compared to Group F. None of he patients included in the study had significant intra-operative hypotension or respiratory depression. Conclusion : The addition of Buprenorphine to Bupivacaine is more efficacious than the addition of fentanyl to Bupivacaine and leads to better intra-operative and post-operative analgesia withourt significant side-effects.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Intrathecal Buprenorphine With Bupivacaine 0.5% and Fentanyl With Bupivacaine 0.5% in Lower Abdominal Surgeries – A Comparative Study

Jobitta

Harshavardhan

2021

ijsr

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“…Another study conducted by Kumar and Kaladhar demonstrated that the onset of analgesia was faster in the butorphanol group than in the buprenorphine group; however, analgesia duration was longer in the buprenorphine group (17). Various studies have demonstrated that buprenorphine is effective as an analgesic for postoperative pain (18)(19)(20).…”

Section: Discussionmentioning

confidence: 99%

Comparison of Epidural Bupivacaine and Buprenorphine to Bupivacaine and Butorphanol for Postoperative Analgesia in Lower Limb Orthopedic Surgery

Savitha

et al. 2023

Anesth Pain Med

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Background: Postoperative analgesia is of utmost importance in the treatment of patients undergoing surgery. Good postoperative pain management reduces hospital stay and improves early ambulation. This study compared the efficacy of epidural bupivacaine with buprenorphine to butorphanol in lower limb orthopedic surgery. Objectives: This study was carried out to investigate the onset of analgesia, the extent of analgesia, sedation score, and side effects of butorphanol with bupivacaine versus buprenorphine with bupivacaine. Methods: In a clinical trial study, 100 patients who underwent elective orthopedic lower limb surgery were randomly allocated to two groups. A total of 100 patients with American Society of anesthesiologists grades I and II posted for lower limb orthopedic surgery were enrolled in this randomized, double-blind study. The patients were divided into groups A and B. Subarachnoid block was achieved with 3.4 mL of 0.5% bupivacaine. The pain was monitored by the visual analog scale postoperatively. The patients in group A received bupivacaine with buprenorphine, and group B received bupivacaine with butorphanol when they complained of pain in the postoperative period. The onset of analgesia, duration of analgesia, sedation score, and side effects were compared between the two groups. Results: The onset of analgesia was observed earlier in group A than in group B (7.7 ± 1.6 vs. 12.6 ± 1.7 minutes, P < 0.001). The duration of analgesia was longer in group A than in group B (590 ± 40 vs. 480 ± 54 minutes, P < 0.001). Pulse rates and mean arterial pressures were significantly different (P < 0.001). Side effects were common in both groups. Conclusions: Buprenorphine added to bupivacaine provides earlier onset and longer postoperative epidural analgesia than epidural butorphanol with bupivacaine.

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Comparative Evaluation of Butorphanol and Fentanyl for Epidural Analgesia in Lower Limb Surgeries

Grewal¹,

Kaur²,

Kaur³

et al. 2018

jemds

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A Comparative Study of Epidural, Bupivacaine with Buprenorphine and Bupivacaine with Fentanyl in Lower Limb Surgeries

Abstract: Background

Cited by 3 publications

References 2 publications

Efficacy of Intrathecal Buprenorphine With Bupivacaine 0.5% and Fentanyl With Bupivacaine 0.5% in Lower Abdominal Surgeries – A Comparative Study

Efficacy of Intrathecal Buprenorphine With Bupivacaine 0.5% and Fentanyl With Bupivacaine 0.5% in Lower Abdominal Surgeries – A Comparative Study

Comparison of Epidural Bupivacaine and Buprenorphine to Bupivacaine and Butorphanol for Postoperative Analgesia in Lower Limb Orthopedic Surgery

Comparative Evaluation of Butorphanol and Fentanyl for Epidural Analgesia in Lower Limb Surgeries

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