A comparative study of calcium phosphate formation on bioceramics in vitro and in vivo

Xin, Renlong; Leng, Yang; Chen, Jiyong; Zhang, Qiyi

doi:10.1016/j.biomaterials.2005.04.028

Cited by 247 publications

(179 citation statements)

References 21 publications

(27 reference statements)

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“…In accordance with similar experiments observed in the literature the quantity and size of the grains deposited act as somewhat quantitative indicators of the ability to induce precipitation of Ca-P (confirmed by EDS), and observing the images obtained by SEM, no perceptible difference appears in the comparison between the two materials, within these parameters. The results of the experiments with SBF approached, visually, those obtained with other ceramic materials such as α-tricalcium phosphate (α-TCP) and bi-phasic hydroxyapatite/α-tricalcium phosphate (HA/TCP) 50 , and better than the results obtained with sintered Bioglasss® (BG) 51 In the contact tests with VERO cells there was also no difference between the samples. The biocompatible character of the materials is reinforced, even if there are no conclusive indexes, considering the absence of in vivo tests.…”

Section: Discussionmentioning

confidence: 53%

Nacre Compared to Aragonite as a Bone Substitute: Evaluation of Bioactivity and Biocompatibility

Almeida¹,

Silva²,

Nakamura³

et al. 2015

Mat. Res.

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Aragonite is a metastable polymorph of calcium carbonate found in mollusk's shells, appearing in tiles and prismatic columns, cemented in a protein matrix -mainly proteins -that acts as a framework on which the aragonite is nucleated forming nacre, besides selecting the morphology of the nucleated cristaline phase. The presence of the mineralyzing organic matrix may affect osteoinductive properties of biogenic aragonite, hypothesis tested by combinated tests, comparing viability and bioactivity of biomineralizated aragonite and nacre. Bioactivity was observed by deposition of Ca-P (presumably calcium phosphate) on the surface of samples immersed in Simulated Body Fluid; biocompatibility was verified by adhesion with VERO cells; cytotoxicity and alkaline phosphatase activity assays were performed with human adipose stem cells (hASC). Samples were characterized by scanning electron microscopy and X-ray diffraction. Both materials showed similar behaviour on bioactivity assay; in contrast, exhibited different behaviours in the presence of hASC.

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Section: Discussionmentioning

confidence: 53%

Nacre Compared to Aragonite as a Bone Substitute: Evaluation of Bioactivity and Biocompatibility

Almeida¹,

Silva²,

Nakamura³

et al. 2015

Mat. Res.

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“…Numerous studies report the formation of an apatite layer between bone and implant, up to 1000 mm in thickness [36,[47][48][49], commonly accepted to occur through a dissolution-reprecipitation process [47]. Composition and orientation of this layer is debated to date [50][51][52][53][54][55]. In our recent work, we employed ET for the study of the first biomaterial-bone interface in nanoscale three-dimensional resolution [36].…”

Section: (A) Hydroxyapatite-bone Interfacementioning

confidence: 99%

High-resolution three-dimensional probes of biomaterials and their interfaces

Grandfield

Palmquist

Engqvist

2012

Phil. Trans. R. Soc. A.

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Interfacial relationships between biomaterials and tissues strongly influence the success of implant materials and their long-term functionality. Owing to the inhomogeneity of biological tissues at an interface, in particular bone tissue, two-dimensional images often lack detail on the interfacial morphological complexity. Furthermore, the increasing use of nanotechnology in the design and production of biomaterials demands characterization techniques on a similar length scale. Electron tomography (ET) can meet these challenges by enabling high-resolution three-dimensional imaging of biomaterial interfaces. In this article, we review the fundamentals of ET and highlight its recent applications in probing the three-dimensional structure of bioceramics and their interfaces, with particular focus on the hydroxyapatite-bone interface, titanium dioxide-bone interface and a mesoporous titania coating for controlled drug release.

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“…(4) Differences in calcium orthophosphate precipitation among the bioceramic surfaces were less noticeable in vitro than that in vivo. (5) β-TCP bioceramics showed a poor ability of calcium orthophosphate precipitation both in vitro and in vivo [639]. These findings clearly revealed that apatite formation in the physiological environments could not be confirmed as the common feature of bioceramics.…”

Section: Bioactivitymentioning

confidence: 92%

“…An important study on formation of calcium orthophosphate precipitates on various types of bioceramic surfaces in both simulated body fluid (SBF) and rabbit muscle sites was performed [639]. The http://ccaasmag.org/BIO bioceramics were sintered porous solids, including bioglass, glass-ceramics, α-TCP, β-TCP and HA.…”

Section: Bioactivitymentioning

confidence: 99%

Untitled

2011

BIO

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In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

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A comparative study of calcium phosphate formation on bioceramics in vitro and in vivo

Cited by 247 publications

References 21 publications

Nacre Compared to Aragonite as a Bone Substitute: Evaluation of Bioactivity and Biocompatibility

Nacre Compared to Aragonite as a Bone Substitute: Evaluation of Bioactivity and Biocompatibility

High-resolution three-dimensional probes of biomaterials and their interfaces

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