A Comparative Study of Amoxicillin-Clavulanate and Amoxicillin: Treatment of Otitis Media With Effusion

Chan, Kenny H.; Mandel, Ellen M.; Rockette, Howard E.; Bluestone, Charles D.; Bass, Lee W.; Blatter, Mark M.; Breck, Jane; Reisinger, Keith S.; Wolfson, Jerome H.; Wucher, F. P.

doi:10.1001/archotol.1988.01860140040017

Cited by 37 publications

(7 citation statements)

References 16 publications

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“…On follow up, only 9 cases (16.36%) responded well and the remaining 46 cases (83.63%) did not show favourable results. This was supported by study done by Chan et al (1988) [19] . On categorizing air conduction thresholds into 3 groups, the effect of tympanostomy and adenoidectomy on hearing impairment was analyzed.…”

Section: Discussionsupporting

confidence: 71%

Diagnostic assessment and various treatment modalities of secretary otitis media

Verma¹,

Shahakar²,

Thorat³

et al. 2020

Int. J. Surg. Sci.

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Background: Secretary Otitis Media (SOM) is the commonest cause of hearing difficulty in childhood encountered by the Otologist. It is characterized by accumulation of effusion in the middle ear cavity due to altered mucociliary system within middle ear and Eustachian tube. Objectives: To study the common clinical features of Secretary Otitis Media (SOM) and its various treatment modalities. Methods: In our study total 55 subjects with secretary otitis media in less than or equal to 13 years of age were assessed. Demographic data, detail case history and Clinical examination were recorded. Complete otolaryngological examination including ear, TFT, ET Function, nose and throat. Blood investigations, urine examination, audiological examinations like pure tone audiometry and impedance audiometry, Urine investigation, Radiological examinations were performed. Microbiological testing of ear effusion and diagnostic nasal endoscopy (DNE) were performed. All the patients were treated first on medical line then followed up for 4 weeks. Refractory cases were considered for surgical modality of treatment like myringotomy with grommet insertion, adenoidectomy with grommet insertion and adenotonsillectomy with grommet insertion. Results: Most of the cases showed significant improvement in signs and symptoms. Good results were seen mostly in patients who had undergone adenotonsillectomy, adenoidectomy with grommet insertion and in hearing threshold. Post operatively most common complication found was mucopurulent discharge after grommet insertion and at electasis changes. Conclusion: Attention should be paid to parental concern regarding their child's hearing particularly if there is a recent history of acute otitis media.

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Section: Discussionsupporting

confidence: 71%

Diagnostic assessment and various treatment modalities of secretary otitis media

Verma¹,

Shahakar²,

Thorat³

et al. 2020

Int. J. Surg. Sci.

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“…The findings of this clinical t rial involving 108 children were published by the OMRC in 1988, with Chan et al 28 concluding that both antibiotics (Augmentin and amoxicillin) were equally effective. According to Chan et al, the cure rate for amoxicillin-treated subjects at the 4-week encl point was 51.5%.…”

Section: Comparison With Other Omrc Studiesmentioning

confidence: 80%

Antimicrobial Therapy for Otitis Media With Effusion ('Secretory' Otitis Media)

Cantekin¹

1991

JAMA

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“…In terms of design, 78 used a clinical design , 43 a single-tap design , and 23 a double-tap design . Eleven trials [152][153][154][155][156][157][158][159][160][161][162] were a variant of a double-tap trial design wherein only the clinical failures had a second tympanocentesis (tap failure design). Two additional trials [163,164] were a variant of a clinical trial design with a clinical diagnosis and outcome measures but failures had a tympanocentesis.…”

Section: Resultsmentioning

confidence: 99%