A comparative study between oral tranexamic acid versus oral tranexamic acid and Q-switched Nd-YAG laser in melasma treatment: a clinical and dermoscopic evaluation

Dermoscopy as a useful tool for evaluating melasma and assessing the response to 1064‐nm Q‐switched Nd: YAG laser

“…In melasma, dermoscopy is superior to Wood's light in terms of detection of pigmentary pattern and density of melanin as well as the vascularity. 13,14 This study aimed to analyze the dermoscopic changes in the pig- These results was attributed to the fact that the 1064-nm treatments can penetrate to deep tissues affecting mainly the dermis and sparing the epidermis, whereas the 1064-nm subthermolytic lowenergy treatments result in photoacoustic melanosomal disruption and destruction of blood vessels while leaving keratinocytes and melanocytes intact with subsequent less tissue damage and complications. 18 In concordance with our results, several studies had reported the efficacy of Qs Nd:YAG laser in melasma.…”

Dermoscopy in Monitoring and Predicting Therapeutic Response in General Dermatology (Non-Tumoral Dermatoses): An Up-To-Date Overview

“…Dermoscopic features of melasma include light/dark brown, grey or blue pseudonetwork (pigmentation with follicular and appendages ostia sparing) and, less commonly, telangiectasias (which are usually less thick than steroid overuse-induced vessels) as well as pigmented annular or arcuate structures, dots and globules [49][50][51][52][53][54].…”

“…The role of dermoscopy in therapeutic management of melasma has been investigated by several studies including patients treated with either topical treatments (tranexamic acid, hydroquinone, and combinations of hydroquinone, glycolic acid and hyaluronic acid) or laser therapies [49][50][51][52][53][54]. Besides the use of this technique in following up lesions changes during the treatment to see the attenuation/regression of pigmentary and vascular structures, dermoscopic examination also has a role in predicting therapeutic response in melasma as it allow one to establish the deepness of the lesions, i.e.…”

“…Besides the use of this technique in following up lesions changes during the treatment to see the attenuation/regression of pigmentary and vascular structures, dermoscopic examination also has a role in predicting therapeutic response in melasma as it allow one to establish the deepness of the lesions, i.e. epidermal (dark to light brown colour and sharp edges), dermal (grey to blue colour with ill-defined margins with or without annular/arcuate pigmented structures) or mixed (combination of dermoscopic findings), with the last two variants being notoriously more resistant to therapies [49][50][51][52][53][54].…”

Progress and prospect of non-invasive detection techniques in the therapeutic evaluation of melasma

“…[ 17 ] Moreover, it can be used to observe changes in blood vessels in a timely and dynamic manner. [ 18 ] Naglaa et al [ 19 ] performed the evaluations using modified MASI (mMASI) and dermoscopy. The dermoscopic examination showed a decrease in the density of pigmentation and a decrease in the severity of skin telangiectasia after treatment and at the follow-up.…”