A comparative study between intralesional PPD and vitamin D3 in treatment of viral warts

Abstract

<p class="abstract"><strong>Background:</strong> Viral warts are caused by human papillomavirus. There are innumerable treatment modalities but they may result in partial clearance or recurrence. Some newer and effective treatments include intralesional immunotherapy. We undertook a study to evaluate the safety and efficacy of two such immunotherapy namely tuberculin purified protein derivative (PPD) versus intralesional vitamin D3 for the treatment of viral warts.</p><p class="abstract"><strong>Methods:</strong> A total of 80 patients were included in the study. Group 1 patient were injected with 10 TU of tuberculin PPD (0.1 ml) intralesional while in group 2 patients were injected (0.5 ml) vitamin D3. The clinical assessment was done by photographic measurements at baseline, before each treatment session, and after the completion of treatment.<strong></strong></p><p class="abstract"><strong>Results:</strong> In group 1 A total of 80% (32 patients) showed complete clearance and 20% (8 patients) showed partial response while in group 2 72.5% (29 patients) showed complete clearance while 27.5% (11 patients) showed partial response. No significant side effects were observed except for pain at the site of injection.</p><p class="abstract"><strong>Conclusions:</strong> Intralesional vitamin D and intralesional Tuberculin PPD immunotherapy shows significant results in treatment of viral warts.</p>

Efficacy and safety of intralesional injection of vitamin D3 versus tuberculin PPD in the treatment of plantar warts: A comparative controlled study

“…There was an insignificant correlation between the number of lesions and the response to treatment. This is the same as reported by the recent study done by Singh et al 20 These findings may suggest that Vit.D 3 is highly effective regardless of the number of lesions. However, large‐scale studies are important to confirm these findings.…”

“…In our study, IL Vit.D 3 resulted in complete clearance of lesions in 70% of patients with plantar warts. In a recent study by Singh et al, 20 the response in Vit.D 3 group was complete cure in 29 patients (72.5%) which was similar to our study, while in PPD group, complete cure was reported in 32 patients (80%) which is higher than results of the current study that may be explained by increased number of sessions.…”

“…Its effects are mediated through VDR, which is present in keratinocytes, melanocytes, fibroblasts, and immune system cells of the skin 10 . It was observed that there is TLR activation of human macrophages which upregulates the expression of VDR and Vit.D‐1‐hydroxylase genes, leading to expression and secretion of antimicrobial peptides 20 …”

Intralesional vitamin D3 versus Candida antigen immunotherapy in the treatment of multiple recalcitrant plantar warts: A comparative case–control study

“…The response rate achieved was 78.57% with complete clearance in 82.60% of patients with palmoplantar warts. In addition, Singh, Mohan, Gupta, and Pandey () compared intralesional vitamin D3 with purified protein derivative (PPD) in various types of warts. Their results revealed that PPD was superior to vitamin D3 where 80% in the former group showed complete response versus 72.5% in the latter group but with no statistical significance.…”

Measurement of serum glutathione peroxidase, catalase and superoxide dismutase concentration in patients with external anogenital warts before and after treatment with intralesional tuberculin purified protein derivative

“…Our results in this entity are closely matching to Abd El‐ sabour, Mohamed, and El Taiebb (2019) who found that in 62 patients injected with tuberculin PPD, 43 patients (69.4%) showed full cure and 13 (20.9%) patient showed weak response, six patients were lost from follow‐up. Singh, Mohan, Gupta, and Pandey (2018) compared between intralesional PPD and vitamin D3 in of viral warts treatment on 40 patients and he found that complete wart recovery occurred in 32 (80%) of patients, partial recovery occurred in 6 (15%) patients, and no response was found in two patients (5%). In the same direction, Saoji, Lade, Gadegone, and Bhat (2016) reported that out of 55 patients injected intralesionally by PPD, complete clearance was found in 42 (76%) of patients after four sessions while no efficacy was reported in 13 (24%) patients.…”