A Comparative Laboratory Study of Liquid Nitrogen and Argon Gas Cryosurgery Systems

Hewitt, Peter; Zhao, Jing; Akhter, Javed; Morris, David L.

doi:10.1006/cryo.1997.2039

Cited by 59 publications

(28 citation statements)

References 6 publications

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“…Argon-based systems have been shown to achieve a more rapid rate of freezing than liquid nitrogenbased systems [23]. Bickels et al [24] hypothesized that the use of a controlled system to deliver the cryogenic substance and the use of a cold-conducting medium would give a more efficient treatment through more precise control of the freezing temperature and duration.…”

Section: Discussionmentioning

confidence: 99%

Lower recurrence rate in chondroblastoma using extended curettage and cryosurgery

Mashhour

Rahman

2013

International Orthopaedics (SICOT)

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Purpose Various methods for the treatment of chondroblastoma of bone have been used including simple curettage, or combined with bone grafting, in addition to the use of adjuvant therapy. However, local recurrence still represents a challenge in the management of this aggressive tumour. This study focuses on evaluating the role of intraregional extended curettage together with the use of adjuvant cryotherapy and autogenous bone grafting in the treatment of benign chondroblastoma of bone aiming to decrease the recurrence rate. Methods All patients with chondroblastoma included in this study underwent intralesional extended curettage, adjuvant cryotherapy using liquid nitrogen, and autogenous iliac crest bone grafting. Follow up for healing of chondroblastoma lesions and detection of any local recurrence was assessed on clinical and radiological bases. The functional outcome was assessed by the Musculoskeletal Tumour Society scoring system. Results The mean follow-up period was 49 months. The average time for bone healing was 7.4 months. Our rate of local recurrence is 7.1 %. Two patients (14.3 %) developed physeal growth arrest. One patient had superficial skin sloughing (7.1 %). None of the cases had pathological fracture. The mean Musculoskeletal Tumour Society functional score was 92.7 %. Conclusion Chondroblastoma is an aggressive benign bone tumour with a high rate of recurrence. The use of high-speed burr combined with adjuvant intralesional cryotherapy and iliac crest autogenous bone grafting is a reliable method of treatment with a low rate of recurrence.

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Section: Discussionmentioning

confidence: 99%

Lower recurrence rate in chondroblastoma using extended curettage and cryosurgery

Mashhour

Rahman

2013

International Orthopaedics (SICOT)

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“…18 To thaw the tissue, high-pressure helium gas, usually at 140-205 bar (2000-3000 psi) was used which generated a temperature of up to 35°C. The gas (argon or helium) fl ows from the highpressure cylinders through the gas delivery and control system, up to the therapeutic probe.…”

Section: Cryoablation Systemmentioning

confidence: 99%

Percutaneous MR-guided cryoablation for malignancies, with a focus on renal cell carcinoma

et al. 2007

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Cryosurgery is the oldest thermal ablation method, and was first performed in the mid-nineteenth century. Since the development of cryosurgical systems capable of delivering liquid nitrogen, organs in various regions have been treated with cryosurgery. However, the lack of an adequate monitoring modality during the freezing process did not allow the precise and complete destruction of lesions deep inside the parenchyma. This led to local recurrences caused by unsatisfactory results of treatment. Recently, a magnetic resonance (MR)-compatible argon-based cryoablation system has been developed, and a combination of this cryoablation system and MR imaging has been shown to be an effective method for treating malignant tumors. In this article, we describe our clinical experience of percutaneous MR-guided cryoablation for malignancies, focusing on renal cell carcinoma.

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“…In this situation, the liquid nitrogen device reached a lower end temperature than the argon gas device (argon gas: À120°C, liquid nitrogen: À140°C). This is explained by the lower boiling temperature of liquid nitrogen compared to argon gas [8].…”

Section: Ex Vivo Vs In Vivo Experimentsmentioning

confidence: 99%

Comparison of two devices for the treatment of keloid scars with the use of intralesional cryotherapy: An experimental study

et al. 2015

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A Comparative Laboratory Study of Liquid Nitrogen and Argon Gas Cryosurgery Systems

Cited by 59 publications

References 6 publications

Lower recurrence rate in chondroblastoma using extended curettage and cryosurgery

Lower recurrence rate in chondroblastoma using extended curettage and cryosurgery

Percutaneous MR-guided cryoablation for malignancies, with a focus on renal cell carcinoma

Comparison of two devices for the treatment of keloid scars with the use of intralesional cryotherapy: An experimental study

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