A Comparative Investigation of Chemical Decontamination Methods for In-Situ Cleaning of Dental Implant Surfaces

Abstract

Surface chemistry evaluation is crucial in assessing the efficacy of chemical decontamination products for titanium implants. This study aimed to investigate the effectiveness of chemical decontamination solutions in cleaning a contaminated dental implant surface and to evaluate the potential of combining Pluronic gel with hydrogen peroxide (NuBone®Clean) by evaluating pellicle disruption and re-formation on implant surfaces. In addition, ensuring safety with in vitro and human testing protocols. X-ray Photoelectron Spectroscopy (XPS) was utilised for surface analysis. All the tested gels had some effect on the surface cleanness except for PrefGel®. Among the tested chemical decontamination candidates, NuBone®Clean demonstrated effectiveness in providing a cleaner titanium surface. Furthermore, none of the tested chemical agents exhibited cytotoxic effects, and the safety assessment showed no adverse events. The results of this study highlight the significance of conducting comprehensive evaluations, encompassing safety and efficacy, before introducing new chemical agents for dental treatments. The findings suggest that NuBone®Clean shows potential as a chemical decontamination solution for implant surfaces. However, further investigation through randomised clinical trials is necessary. By adhering to rigorous testing protocols, the development of safe and efficient chemical decontamination strategies can be advanced, benefiting patients and promoting progress in implant dentistry.

Towards a better understanding of the effect of protein conditioning layers on microbial adhesion: a focused investigation of fibronectin and bovine serum albumin layers on SiO2 surfaces

“…They can be deposited, by a plasma (electrical discharge) based process 24 on various surfaces, including titanium, which is largely applied for different kinds of medical implants. 25 Thus, this study represents a part of a much broader project aiming at elaboration of antimicrobial surfaces involving SiO 2 as a host matrix, to be applied as coating layers for implantable medical devices.…”

“…Moreover, the plasma deposition of thin silica layers allows the development of strategies for surface coating of different medical implants, for example titanium-made dental implants. 25 All these potential applications of SiO 2 thin layers require a deeper understanding of the physicochemical properties and the basic principles of the complex material surface–microbiological interactions. 26…”

“…Moreover, the plasma deposition of thin silica layers allows the development of strategies for surface coating of different medical implants, for example titanium-made dental implants. 25 All these potential applications of SiO 2 thin layers require a deeper understanding of the physicochemical properties and the basic principles of the complex material surface-microbiological interactions. 26 Therefore, the main objective of this study was to explore the evolution of the adhesion and detachment profiles of opportunistic microorganisms (Pseudomonas aeruginosa and Candida albicans) on the surface of thin silica (SiO 2 ) layers after conditioning with a thin layer of human plasma fibronectin (Fn) or of bovine serum albumin (BSA).…”