A ComparativeIn VitroStudy of the Effects of Separate and Combined Products ofCitrus e fructibusandCydonia e fructibuson Immunological Parameters of Seasonal Allergic Rhinitis

Baars, Erik W.; Jong, Miek C.; Boers, Inge; Nierop, Andreas F M; Savelkoul, H.F.J.

doi:10.1155/2012/109829

Cited by 10 publications

(14 citation statements)

References 21 publications

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“…Orange essential oils significantly reduced the serum ALT level when compared to CCl 4 group, while it did not affect the serum AST level. The histopathological findings did not show any significant difference between the orange essential oils treated and CCl 4 groups (226) .…”

Section: Protective Effectmentioning

confidence: 64%

Nutritional value and pharmacological importance of citrus species grown in Iraq

Al-Snafi¹

2016

IOSRPHR

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Citrus fruits contained many phytochemicals including essential oils, alkaloids, flavonoids, coumarins, psoralens, carotenoids with a wide range of nutritional components including vitamins, minerals and trace elements. The previous pharmacological studies revealed that citrus fruits possessed antimicrobial, anthelmintic, insect repellent, antioxidant, anticancer, cardiovascular, central nervous, anti-inflammatory, analgesic, antidiabetic, reproductive, gastrointestinal, immunological, respiratory and many other pharmacological effects. This review was designed to highlight the chemical constituents, nutritional value and pharmacological activities of citrus fruits.

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Section: Protective Effectmentioning

confidence: 64%

Nutritional value and pharmacological importance of citrus species grown in Iraq

Al-Snafi¹

2016

IOSRPHR

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“…All single interventions seemed to provide an additional effect, making it worthwhile to apply them multimodally [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 27 ]. This may make it difficult to sort out individual contributions to the outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…The effect of this combination is based on decongestant, astringent [ 18 ] and immunomodulatory [ 19 , 20 ] properties, i.e., anti-inflammatory [ 21 ], antibacterial [ 22 ], and antiallergic properties [ 23 , 24 , 25 ].…”

Section: Methodsmentioning

confidence: 99%

The P.E.A.N.U.T. Method: Update on an Integrative System Approach for the Treatment of Chronic Otitis Media with Effusion and Adenoid Hypertrophy in Children

et al. 2021

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Background and objectives: Based on our previous single-center study on optimization of treatment of chronic otitis media with effusion (COME) and adenoid hypertrophy (AH) in children using a noninvasive system approach to lower the necessity of antibiotics, analgesic use, and surgical interventions, we proceeded to perform a multicenter investigation in an outpatient setting. The purpose of the previous prospective study in 2013–2015 was to compare outcomes in the treatment of COME and AH using the noninvasive multimodal integrative method (IM) versus conventional treatment practice (COM). Materials and Methods: In this paper, we retrospectively analyze the data of patients treated with the integrative method between 2017 and 2020 in a multicenter setting and compared the outcomes with data from 2013–2015 in order to evaluate generalizability. In both periods, all eligible and willing participants were included and treated with the IM protocol under real-life conditions. The treatment involved pneumatization exercises, education, an antiallergic diet, nasal hygiene, useful constitutional therapy, and thermal interventions (P.E.A.N.U.T.). A total of 48 versus 28 patients, aged 1–8, were assessed, presenting with COME and AH, with moderate to severe hearing impairment at entry. Results: The significant improvement found in both audiometric measures (intact hearing) and tympanometric measures (normal A-type curve) was similar in both datasets with respect to conventional treatment. The new data confirms that the P.E.A.N.U.T. method results in a significant reduction of antibiotics, analgesic use, and surgical interventions. Conclusion: In this multicenter trial, we confirm the effectiveness of the noninvasive system approach for the treatment of COME in lowering the need for antibiotics and analgesic use and elective surgery. This could be especially important with respect to a generally observed increase in antibiotic resistance. The method is easy to perform in different clinical settings and is effective, safe, and well-tolerated.

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“…Citrus limon Burm. f. was stimulated on PBMCs at the amount of 0.01 g/mL for 7 days [60]. PBMCs were obtained from the blood of five grass pollen-allergic donors aged 18-40 and five healthy eligible participants who had no sign of allergic rhinitis.…”

Section: In Vitro Studiesmentioning

confidence: 99%

The Natural Products Targeting on Allergic Rhinitis: From Traditional Medicine to Modern Drug Discovery

et al. 2021

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More than 500 million people suffer from allergic rhinitis (AR) in the world. Current treatments include oral antihistamines and intranasal corticosteroids; however, they often cause side effects and are unsuitable for long-term exposure. Natural products could work as a feasible alternative, and this study aimed to review the efficacies and mechanisms of natural substances in AR therapies by examining previous literature. Fifty-seven studies were collected and classified into plants, fungi, and minerals decoction; clinical trials were organized separately. The majority of the natural products showed their efficacies by two mechanisms: anti-inflammation regulating diverse mediators and anti-oxidation controlling the activity of nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) pathway stimulated by reactive oxygen species (ROS). The main AR factors modified by natural products included interleukin (IL)-4, IL-5, IL-13, interferon-gamma (IFN-γ), tumor necrosis factor-α (TNF-α), cyclooxygenase 2 (COX-2), and phospho-ERK1/2 (p-ERK1/2). Although further studies are required to verify their efficacies and safeties, natural products can significantly contribute to the treatment of AR.

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A ComparativeIn VitroStudy of the Effects of Separate and Combined Products ofCitrus e fructibusandCydonia e fructibuson Immunological Parameters of Seasonal Allergic Rhinitis

Cited by 10 publications

References 21 publications

Nutritional value and pharmacological importance of citrus species grown in Iraq

Nutritional value and pharmacological importance of citrus species grown in Iraq

The P.E.A.N.U.T. Method: Update on an Integrative System Approach for the Treatment of Chronic Otitis Media with Effusion and Adenoid Hypertrophy in Children

The Natural Products Targeting on Allergic Rhinitis: From Traditional Medicine to Modern Drug Discovery

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