A comparative evaluation of the biological effects of environmental cadmium-contaminated control diet and laboratory-cadmium supplemented test diet

Asagba, Samuel Ogheneovo; O., F.

doi:10.1007/s10534-004-4257-2

Cited by 14 publications

(3 citation statements)

References 28 publications

(30 reference statements)

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“…We observed lower liver relative weight after Cd exposure, which is in accordance with other studies. 36,37 Liver Cd accumulation ranged from 12 to 14 mg/g tissue, which is in agreement with previous findings. 5,6 Furthermore, we observed that the liver Cd concentration and the amount of Cd retained was higher in the flax-Cd group than in the other Cdgroups.…”

Section: Discussionsupporting

confidence: 92%

Effect of wheat bran and flaxseed on cadmium effects and retention in rats

et al. 2010

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Dietary fiber can affect cadmium (Cd) absorption and toxicity, but the effect appears to depend on the type of dietary fiber. The aim of the present study was to compare the effect of dietary sources containing distinct amounts of soluble and insoluble fiber on Cd absorption, accumulation and toxicity in growing rats. The absorption of essential macrominerals (Ca, P and Mg) was also evaluated. Animals received a nutritionally balanced diet with cellulose (cel — control), wheat bran or flaxseed as the fiber source with 0 or 50 mg Cd kg-1 diet, during 30 days. Cd exposure reduced body weight gain, feed efficiency ratio, epididymal fat relative weight and liver relative weight, and increased plasma alanine aminotransferase activity in all fiber groups. The apparent Cd absorption was similar among Cd-groups, but the flax-Cd group had a higher hepatic and renal Cd concentration. Cd decreased the absorption of Ca and P, and increased Mg absorption in the wheat bran and flaxseed groups, but not in the cel group. Although the different fiber sources investigated had no effect on Cd toxicity, the major soluble fiber source, flaxseed, increased Cd retention. Thus, caution should be taken in the intake of flaxseed by Cd-exposed populations.

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Section: Discussionsupporting

confidence: 92%

Effect of wheat bran and flaxseed on cadmium effects and retention in rats

et al. 2010

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“…Calcium carbide is considered a very hazardous toxin especially as a food processing agent because it contains traces of the heavy metal arsenic. 18 Alteration in body and alteration in body weight is usually considered a toxicity index 1,9 . In this study, there was a slight decrease(P>0.05) in liver body weight ratios of rats exposed to carbide treated banana (CTB) and a significant (P<0.05) decrease in body weight of rats exposed to arsenic only via feed (Table 2).…”

Section: Discussionmentioning

confidence: 99%

Studies of the Biochemical Effects of Arsenic Content of Carbide Induced Ripe Banana Fruit in the Rat

–Douglas¹,

Fadairo²

2019

Orient. J. Chem

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Arsenic is a well-known poison and it is found in trace amount in calcium carbide use for welding purposes and secondarily use by farmers and traders in Warri Metropolis to induce ripening processes in foods. This study was designed to evaluate the concentration of arsenic in selected banana fruits within Warri metropolis. It was also designed to determine its effects on some key biochemical indices of toxicity. The atomic absorption method was used to determine arsenic content of fruits and the biochemical indices evaluated were liver body weight ratio, body weight gain, the extent of lipid peroxidation in the liver organ and plasma, and the activities of alkaline phosphatases in the plasma and liver. Results showed a high concentration of arsenic in carbide-induced ripe banana (CTB) with an average value of 0.11mg/kg wet mass of test banana relative to the carbide-free banana (CFB) control with a value of <0.001 mg/kg. Our findings also showed a slight increase in body weight and decrease in liver body weight ratio of CTB rats, but the changes were not significant P>0.05 when compared to the control (CFB). However, there was a significant (P<0.05) decrease in body weight and increase in organ body weight ratios of arsenic-only exposed rats relative to the control. The activities of alkaline phosphatase in plasma increased significantly (P<0.05) for the groups of rats exposed to CTB and arsenic only via feed relative to their respective controls. The plasma and liver malondialdehyde (MDA) levels of rats exposed to CTB and arsenic only via feed were also elevated in this present study when compared to their respective controls however, the levels were not significant (P>0.05). This study shows the possibility of Plasma -ALP alteration and changes in levels of tissue lipid peroxidation products of carbide -treated ripe banana fruits. There is therefore the need for an urgent regulation on the use of carbide in the induction of ripening of fruits.

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“…Copper 7-10 , Zinc 9-13 , Nickel [14][15][16] and the yeast enzymes in particular are also inhibited by sodium and calcium ions. The effect of the latter can be reduced through the addition of phosphates to complex the calcium and through the heat treatment of milk or whey to precipitate calcium as calcium phosphate.Other minerals ions are responsible for increasing the activity of β-D galactosidase [17][18][19][20][21] . The most important activators are potassium, manganese ions 22,23 .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2012

IJPSR

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Background: Enzyme catalysis is intermediate between homogeneous and heterogeneous catalysis. In general, it is similar to inorganic heterogeneous catalysis and sometimes it is called micro heterogeneous catalysis. Efficient enzyme catalysis depends on high specific nature of enzyme, pH, temperature, optimum temperature, colloidal nature, activator or coenzyme, inhibitors or poisons. Immobilized β-galatosidase show high activity towards both pure lactose and lactose in skim milk, and a better thermal stability also. Methods: This study was done in CDRI, Lucknow. In this study β-galatosidase was extracted by Kluyveromyces lactis and enzyme assay done by GOD/POD method. Partial purification of enzyme was done by precipitation with ammonium sulphate, DEAE-cellulose column chromatography followed by SDS-PAGE. Immobilization of K. lactis cells was done by Entrapment method in which we agarose beads, plyacrylamide beads and alginate beads were used to analyze the catalytic activity of β-galatosidase on different parameters. Results: In this study the effect of temperature, pH, and amino acids on normal β-galatosidase and on immobilized β-galatosidase were analyzed. Immobilized enzyme showed the decreasing conversion level of lactose. We used three types of beads to analyze the activity of enzyme in which polyacrylamide beads showed decreasing conversion level of lactose at different concentration of lactose and same concentration of beads. Effect of temperature on β-galactosidase was maximum at 40

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A comparative evaluation of the biological effects of environmental cadmium-contaminated control diet and laboratory-cadmium supplemented test diet

Cited by 14 publications

References 28 publications

Effect of wheat bran and flaxseed on cadmium effects and retention in rats

Effect of wheat bran and flaxseed on cadmium effects and retention in rats

Studies of the Biochemical Effects of Arsenic Content of Carbide Induced Ripe Banana Fruit in the Rat

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