A Comparative Evaluation of the Three Different Methods of Endometrial Sampling in the Diagnosis of Perimenopausal Bleeding

Patil, Pooja; Sunita, Venigalla; Kumar, M L Harendra; Raju, Kalyani

doi:10.14740/jcgo271w

Cited by 6 publications

(5 citation statements)

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“…96% in both samples. 9 Baral and Pudasini reported adequacy of 92% in endometrial aspiration while conducting a study on patients of abnormal uterine bleeding. 10 In a study conducted by Jairajpuri et al, it was concluded that endometrial aspiration has adequacy of 97.4%.…”

Section: Discussionmentioning

confidence: 99%

A comparative study to evaluate endometrial aspiration using Karman’s cannula versus dilatation and curettage in cases of abnormal uterine bleeding

Tomar

Sandhu

Mahipal

et al. 2020

Int J Reprod Contracept Obstet Gynecol

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Background: Abnormal uterine bleeding (AUB) is defined as any variation from the normal menstrual cycle such as changes in regularity, frequency, duration of flow or amount of flow. Objective of this study was to compare the adequacy and diagnostic accuracy of endometrial aspiration using Karman’s cannula versus dilatation and curettage in women with abnormal uterine bleeding.Methods: This prospective study was conducted on 250 women with AUB in age group of more than 40 years. In all patients, endometrial aspiration was done with manual vacuum aspiration (MVA) syringe attached to 4 mm Karman's cannula without anesthesia. The sample was collected in a bottle containing formalin and was labelled as sample A. After that, intracervical local anesthesia (1% Xylocaine) was given and cervix was dilated and scrapping of endometrial lining with sharp curette was done. The sample was also collected in a bottle containing formalin and was labelled as sample B. Both the samples A and B were sent for histopathology. The histopathology report of aspiration was compared with that of dilatation and curettage sample.Results: Endometrial aspiration biopsy had sensitivity of 92.3%, specificity of 100%, positive predictive value of 100% and negative predictive value of 99.56% for diagnosis of endometrial pathology while considering D and C gold standard. The sample adequacy of endometrial aspiration was 98.8% as compared to dilatation and curettage (98%).Conclusions: Present study showed that endometrial aspiration biopsy is an alternate to traditional dilatation and curettage in diagnosing endometrial pathologies in women with abnormal uterine bleeding.

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Section: Discussionmentioning

confidence: 99%

A comparative study to evaluate endometrial aspiration using Karman’s cannula versus dilatation and curettage in cases of abnormal uterine bleeding

Tomar

Sandhu

Mahipal

et al. 2020

Int J Reprod Contracept Obstet Gynecol

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“…[ 8 ] and Patil et al . [ 9 ] and Kaur et al . [ 10 ] in India as well as in western countries [ 11 12 ] where endometrial aspiration was compared with traditional methods for adequacy of samples.…”

Section: Discussionmentioning

confidence: 99%

Abnormal Uterine Bleeding- evaluation by Endometrial Aspiration

Singh¹

2018

J Mid-life Health

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Endometrial evaluation is generally indicated in cases presenting with abnormal uterine bleeding (AUB), especially in women more than 35 years of age. AUB encompasses a variety of presentation, for example, heavy menstrual bleeding, frequent bleeding, irregular vaginal bleeding, postcoital and postmenopausal bleeding to name a few. Many methods are used for the evaluation of such cases, with most common being sonography and endometrial biopsy with very few cases requiring more invasive approach like hysteroscopy. Endometrial aspiration is a simple and safe office procedure used for this purpose.Materials and Methods:We retrospectively analyzed cases of AUB where endometrial aspiration with Pipette (Medgyn) was done in outpatient department between January 2015 and April 2016. Case records (both paper and electronic) were used to retrieve data.Results:One hundred and fifteen cases were included in the study after applying inclusion and exclusion criteria. Most cases were between 46 and 50 years of age followed by 41–45 years. No cases were below 25 or more than 65 years of age. Heavy menstrual bleeding was the most common presentation of AUB. Adequate samples were obtained in 86% of cases while 13.9% of cases' sample was inadequate for opinion, many of which were later underwent hysteroscopy and/or dilatation and curettage (D and C) in operation theater; atrophic endometrium was the most common cause for inadequate sample. Uterine malignancy was diagnosed in three cases.Discussion:Endometrial aspiration has been compared with traditional D and C as well as postoperative histopathology in various studies with good results. Many such studies are done in India as well as in western countries confirming good correlation with histopathology and adequate tissue sample for the pathologist to give a confident diagnosis. No complication or side effect was noted with the use of this device.Conclusion:Endometrial aspiration is a simple, safe, and effective method to sample endometrium in cases of AUB avoiding risk of anesthesia and is less time-consuming. Many similar devices are also available in the market and need to be popularized in all parts of the country.

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“…Gerbaldo et al 10 used the distension medium in their study where they found that the endometrial washings were considered adequate in 227 patients (93.4%), while they concluded that collection and analysis of the distension fluid is feasible and, when positive, has a remarkable value in the diagnosis of endometrial cancer and its precursors. Patil et al 14 used nasogastric tube no. 10 for endometrial cytology, their study aimed to compare the efficacy of different methods of endometrial sampling.…”

Section: Resultsmentioning

confidence: 99%

Endometrial Flushing Versus Endometrial Brush Cytology in High Risk Women for endometrial carcinoma

Mokbel

2020

Al-Azhar International Medical Journal

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Background: Postmenopausal bleeding (PMB), defined as blood loss occurring at least 12 months after menopause, is a common complaint in general gynecological practice. The prevalence of PMB is approximately 10% immediately after menopause. Aim of work: This study aims to compare two diagnostic methods, Flush and Brush cytology. Patients and Methods: The study population comprises eighty (80) women with postmenopausal bleeding. It was conducted over 12 months from April 2018 to April 2019 on postmenopausal women who were approached, managed and followed up in the Gynecology Clinic of Minia General Hospital to compare between two diagnostic methods Flush and Brush cytology using the standard D&C as a comparative test. Results: The statistical results showed that the subjective pain varied significantly between the two methods: Brush and Flush. However, that difference was too little to be of clinical value. On the other hand, the objective pain showed no statistically significant difference between the two methods. Regarding tissue yield, the D&C method provided significantly more adequate samples (88.8%) compared with both the Flush (30%) and Brush (53.8%) methods (p-values, <0.05). Also, the difference between the Brush and Flush methods was statistically significant (p-value <0.05). Conclusion: Flush and Brush are simple methods, associated with comparable pain scores. However, they have modest tissue yield which limits their clinical applicability in the screening of endometrial abnormalities in patients with postmenopausal bleeding.

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A Comparative Evaluation of the Three Different Methods of Endometrial Sampling in the Diagnosis of Perimenopausal Bleeding

Cited by 6 publications

References 0 publications

A comparative study to evaluate endometrial aspiration using Karman’s cannula versus dilatation and curettage in cases of abnormal uterine bleeding

A comparative study to evaluate endometrial aspiration using Karman’s cannula versus dilatation and curettage in cases of abnormal uterine bleeding

Abnormal Uterine Bleeding- evaluation by Endometrial Aspiration

Endometrial Flushing Versus Endometrial Brush Cytology in High Risk Women for endometrial carcinoma

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