A comparative diagnostic study of head and neck nodal metastases using positron emission tomography

McGuirt, W. Frederick; Williams, Daniel W.; Keyes, John W.; Greven, Kathryn M.; Watson, Nat E.; Geisinger, Kim R.; Cappellari, James O.

doi:10.1288/00005537-199504000-00006

Cited by 125 publications

(65 citation statements)

References 7 publications

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“…Since PET studies indicate the metabolic changes, it provides information about the lesion earlier than the other imaging methods and PET-CT studies contribute to the early diagnosis and correct staging of the disease due to the fact that anatomical localization and details are indicated with CT (14). In many studies conducted to determine lymph node metastasis, PET-CT has been found to have higher sensitivity (64%-100%) and specifity (67%-100%) and a more frequently preferred method when compared to MRI and CT (15,16 Liao et al's (19) study including 473 patients, when SUV-max threshold value is taken as 3.1, sensitivity and specifity were found 79.9% and 59.4% respectively. In our study when the threshold value is taken as 2.5 in detection of the metastatic region in the neck, sensitivity, specifity, PPD and NPD and accuracy were found 73%, 91%, 40.7%, 96.6% and 86% respectively.…”

Section: Discussionmentioning

confidence: 99%

The Role of PET-CT in Evaluation of Cervical Lymph Node Metastases in Oral Cavity Squamous Cell Carcinomas

Çaylaklı

Yılmaz

Özer

et al. 2015

Turk Arch Otorhinolaryngol

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Objective: The aim of this study is to determine the sensitivity and specificity of positron emission tomography-computed tomography (PET-CT) in the evaluation of cervical lymph node metastasis in oral cavity squamous cell cancers (SCCs) and to determine the SUV-max values in differentiating reactive and metastatic lymph nodes as a supportive parameter. Methods:In this study, 23 patients were included who were diagnosed with oral cavity SCC and treated with surgery between 2006 and 2013 in our department. All the patients were scanned with PET-CT during the pretreatment evaluation. Detailed pretreatment PET-CT (retention sites and SUV-max values) and histopathological examination results were obtained. SPSS 17.0 software package was used for statistical analysis of the data. Categorical measurement was summarized as number and percentage and continuous measurements as mean and standard deviation (median and minimum-maximum where necessary). Chi-square test or Fisher's test were used in the comparison of categorical variables. Compliance of methods was assessed by Kappa coefficient analysis. In this study, the advantages of PET-CT were determined by the calculation of sensitivity and specificity values with histopathological examination results considered as the gold standard, and SUV-max value was assessed by examining the area under the ROC curve. In all tests, the level of statistical significance was accepted as 0.05. Results:The threshold value for SUV-max depending on the data of the histopathological examination and results of PET-CT of the 23 patients was 2.50. The reliability of this threshold was determined as AUC=0.819. In demonstrating neck metastasis in patients with cancer of the oral cavity, PET-CT has a sensitivity of 89% and specificity of 98%. Compliance between the histopathological examination and PET-CT for metastatic cervical lymph nodes was determined to be 0.416 by kappa coefficient analysis. Conclusion:There was FDG uptake on PET-CT in the cervical lymph node regions of all patients with metastatic cervical lymph nodes. There were no metastases in any of the patients with no FDG retention. The sensitivity and specificity of PET-CT in determining cervical lymph node metastasis were 89% and 98%, respectively, with a threshold SUV-max value considered as 2.50 in patients with FDG retention. Keywords

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Section: Discussionmentioning

confidence: 99%

The Role of PET-CT in Evaluation of Cervical Lymph Node Metastases in Oral Cavity Squamous Cell Carcinomas

Çaylaklı

Yılmaz

Özer

et al. 2015

Turk Arch Otorhinolaryngol

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“…The most important reason that PET/CT is a preferred method over others for contouring target volumes is that it can provide better differentiation of tumor tissue from healthy tissue (McGuirt et al, 1995). Comparing target tumor volumes determined by CT and PET/CT images may result in changing the treatment plan.…”

Section: Discussionmentioning

confidence: 99%

Role of PET/CT in Treatment Planning for Head and Neck Cancer Patients Undergoing Definitive Radiotherapy

Arslan¹,

Abakay²,

Şen³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Although validation of sites of malignancy was not part of this trial design, the accuracy of PET in staging head and neck cancer has been extensively reported in the literature (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)23). Information from referring clinicians as well as from radiology and PET reports was used for lesion evaluation, and no centralized review of the imaging was made.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have evaluated the use of PET in the initial staging of head and neck cancer (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). 18 F-FDG PET may offer advantages over anatomic imaging in the assessment of primary tumors, as it can detect superficial or submucosal primary tumor infiltration without adjacent tissue deformation, and nodal disease (1,2).…”

mentioning

confidence: 99%

PET Changes Management and Improves Prognostic Stratification in Patients with Head and Neck Cancer: Results of a Multicenter Prospective Study

Scott

Gunawardana²,

Bartholomeusz³

et al. 2008

J Nucl Med

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The primary aim of this study was to determine the impact of PET in changing initial management plans in patients with untreated head and neck cancer. Secondary aims were to determine the incremental staging information provided by PET and to document the effect of PET on treatment outcomes. Methods: Patients with untreated head and neck cancer underwent PET scans. Pre-PET management plans were documented by referring clinicians unaware of the PET results, and management plan changes due to PET scan findings were documented. Followup to 12 mo after treatment was performed to determine actual management and clinical outcomes. Results: A total of 71 patients (median age, 56 y; 69% male) were studied. PET scans resulted in management change in 33.8% of patients. Moreover, PET was able to detect additional sites of disease in 39.4% of patients. Follow-up data showed that PET improved the classification of patients into curative and palliative categories. Trends toward inferior disease-free survival and lower complete response rates in patients with additional lesions detected on PET were demonstrated. In addition, a trend toward inferior disease-free survival in patients with a higher maximum standardized uptake value was shown. Conclusion: These data unequivocally demonstrate the significant impact of PET on management and outcomes in patients with untreated head and neck cancer.

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A comparative diagnostic study of head and neck nodal metastases using positron emission tomography

Cited by 125 publications

References 7 publications

The Role of PET-CT in Evaluation of Cervical Lymph Node Metastases in Oral Cavity Squamous Cell Carcinomas

The Role of PET-CT in Evaluation of Cervical Lymph Node Metastases in Oral Cavity Squamous Cell Carcinomas

Role of PET/CT in Treatment Planning for Head and Neck Cancer Patients Undergoing Definitive Radiotherapy

PET Changes Management and Improves Prognostic Stratification in Patients with Head and Neck Cancer: Results of a Multicenter Prospective Study

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