A comparative cross-sectional study of some hematological parameters of hypertensive and normotensive individuals at the university of Gondar hospital, Northwest Ethiopia

Enawgaw, Bamlaku; Adane, Nigist; Terefe, Betelihem; Asrie, Fikir; Melku, Mulugeta

doi:10.1186/s12878-017-0093-9

Cited by 22 publications

(27 citation statements)

References 38 publications

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“…In this study the mean value for Hb was shown to be lower among hypertensive compared to normotensive subjects (p > 0.05). Our finding agrees with the finding in a previous study conducted in São Paulo, Brazil [31]. Our finding is however at variance with previous report [32] which shows that Hb value was significantly increased in the hypertensive group compared to normotensive groups.…”

Section: Discussionsupporting

confidence: 89%

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Some Full Blood Count Parameters among Hypertensive Patients Attending Specialist Hospital, Sokoto, Nigeria

Erhabor¹,

Shehu²,

Erhabor³

et al. 2019

OJBD

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Hypertension (HTN) is a major health problem worldwide. It can lead to cardiovascular disease and functional disturbances including haematological parameters. Full blood count (FBC) parameters of a total of 60 consecutively-recruited hypertensive subjects and 30 age-matched non-hypertensive controls were studied between June and September, 2018. Ethylene Diamine Tetra Acetic Acid (EDTA) anticoagulated blood and serum from subjects and control participants were analyzed for FBC. The total white cell count (WBC), packed cell volume (PCV) haemoglobin (Hb), neutrophils and eosinophils were significantly lower among hypertensive subjects compared to non-hypertensive controls (p < 0.01, p = 0.02, p < 0.01, p < 0.01, p < 0.01) respectively. The red cell count, monocyte and lymphocyte count were significantly higher among the hypertensive subjects compared to controls (p = 0.00). There was a statistically significant variation in the haemoglobin, platelet count and red cell distribution width among the hypertensive subjects based on the stage of the hypertensive disease (p < 0.01, p = 0.01 and p < 0.01) respectively. The haematological parameters were compared among the hypertensive subjects based on age, gender and ethnicity. The PCV and platelet count were significantly higher among hypertensives >40-year-old compared to those <40 years of age (p = 0.02 and 0.01) respectively. The RBC count was significantly higher among female compared to male hypertensives (p = 0.05). The haemoglobin and monocyte count were significantly higher among male compared to female hypertensives (p = 0.02 and 0.04) respectively. The monocyte count was significantly higher among hypertensive subjects of Hausa ethnic group compared to Fulani (t = 2.79, p < 0.

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Section: Discussionsupporting

confidence: 89%

“…Increased MPV has been shown in patients with cardiovascular diseases and in patients' groups with known coronary artery disease risk factors. Moreover, increased MPV has also prognostic role in cardio-vascular diseases, for example, it is associated with higher mortality following myocardial infarction [31].…”

Section: Discussionmentioning

confidence: 99%

Some Full Blood Count Parameters among Hypertensive Patients Attending Specialist Hospital, Sokoto, Nigeria

Erhabor¹,

Shehu²,

Erhabor³

et al. 2019

OJBD

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“…In the present study, the median± IQR values of Hgb were found to be significantly higher in the hypertensive (14.50±1.93) than in control (13.78±2.13) group. Studies from India [ 15 ], Iran [ 7 ], Korea [ 9 ] and Ethiopia [ 8 ] found similar results. In contrast, studies from Brazil [ 20 ], Saudi [ 19 ] and India [ 21 ] Showed contradicting result.…”

Section: Discussionmentioning

confidence: 61%

A comparative study of hematological parameters between hypertensive and normotensive individuals in Harar, eastern Ethiopia

2021

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Background Hypertension is the major public health concern; leading to cardiovascular disease. It is associated with alteration in hematological parameters which may lead to end-organ damage. Thus, this study aimed to compare hematological parameters between hypertensive and normotensive adult groups in Harar, eastern Ethiopia. Methods A comparative cross-sectional study was conducted from January to March, 2020 at Jugel and Hiwotfana Specialized University hospital, Harar, eastern Ethiopia. Convenient sampling technique was used to recruit 102 hypertensive patients from the two hospitals and 102 apparently healthy blood donors. Participant’s socio-demographic and clinical information were collected using pre-tested structured questionnaire. Blood sample were collected and analyzed by Beckman Coulter DxH 500 analyzer for complete blood count. The data were entered and analyzed using SPSS version 23. Independent t-test and Mann Whitney u-test was used for comparison between groups. Spearman’s correlation was used for correlation test. P values less than 0.05 was considered as statistically significant. Result 102 hypertensive and 102 healthy controls were enrolled in this study. The median ± IQR value of white blood cell (WBC) count, hemoglobin (Hgb), hematocrit (HCT), red cell distribution width (RDW) and mean platelet volume (MPV) were significantly higher in hypertensive group compared to apparently healthy control group. Additionally, RBC (red blood cell) count, HCT and RDW showed statistically significant positive correlations with systolic and diastolic blood pressure. WBC count and RDW were significantly and positively correlated with body mass index (BMI). Platelet (PLT) count had a significant but negative correlation (r = -0.219, P = 0.027) with duration of hypertension illness while MPV showed positive and significant correlation (r = 0.255, P = 0.010). Conclusion The median values of WBC, Hgb, HCT, RDW and MPV were significantly higher in hypertensive patient compared to apparently healthy individuals. Hence, it is important to assess hematological parameters for hypertensive individuals which may help to prevent complications associated with hematological aberrations. However, further studies are required to understand hypertensive associated changes in hematological parameters.

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“…Además, las plaquetas secretan un amplio espectro de mediadores de la función endotelial, la coagulación e inflamación y se afectan por el estado inflamatorio sistémico. El VPM ha sido relacionado con la función plaquetaria y puede ser considerado un nuevo factor de riesgo de aterotrombosis, por lo que ha sido propuesto como un biomarcador de uso pronóstico en pacientes con enfermedad cardiovascular 29 y se ha asociado con otros factores de riesgo como hipertensión y disfunción endotelial 30 . De acuerdo con nuestros resultados, el consumo de alimentos ricos en grasa podría contribuir desde las alteraciones plaquetarias al desarrollo de enfermedad cardiovascular.…”

Section: Discussionunclassified

El agregado de aceite de Sacha inchi disminuye la relación granulocitos/linfocitos postprandial producida por una comida rica en grasas, en adultos saludables

2021

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A comparative cross-sectional study of some hematological parameters of hypertensive and normotensive individuals at the university of Gondar hospital, Northwest Ethiopia

Cited by 22 publications

References 38 publications

Some Full Blood Count Parameters among Hypertensive Patients Attending Specialist Hospital, Sokoto, Nigeria

Some Full Blood Count Parameters among Hypertensive Patients Attending Specialist Hospital, Sokoto, Nigeria

A comparative study of hematological parameters between hypertensive and normotensive individuals in Harar, eastern Ethiopia

El agregado de aceite de Sacha inchi disminuye la relación granulocitos/linfocitos postprandial producida por una comida rica en grasas, en adultos saludables

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